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The United Kingdom Thrombotic Thrombocytopenic Purpura Registry Non substantial Amendment 3 - change to proposed end date. TG 13/07/10 Amendment 4 - changes to protocol to clarify that participant consent will be obtained once they are in remission. Those not able to consent will be excluded. Study blood will only be taken after participant consent obtained. PIS, Consent and Assent forms have been updated to reflect the changes in the protocol. TG 13/07/10