Characterisation of a panel of disease biomarkers in peripheral blood from individuals with amyotrophic lateral sclerosis/motor neuron disease

Research summary

This study will evaluate the expression of neurofilaments and of other relevant molecules in blood samples taken from individuals with amyotrophic lateral sclerosis at different time points during the development of the disease. Our aim is to validate easily accessible disease biomarkers functioning as reliable predictors of disease severity and capable of providing information about the stratification of the disease phenotypes. Control groups will include healthy individuals and patients with a compressive radiculopathy. Recruitment will take place in 4 motor neuron disease Clinics serving a population of approximately 7,000,000 in North-East London, Heredforshire and Essex. A similar study is currently ongoing in animal models of the disease.

Principal Investigator

Prof Martin Turner

Contact us

Email: dendron@ouh.nhs.uk

Phone: 01865231556

IRAS number

47352