Should we use post-operative antibiotics following surgery for patients with mandible fractures? The MANTRA trial (MANdibular TRauma and Antibiotic use) (MANTRA)

Research summary

The MANTRA trial is an open label, non-blinded, multicentre non-inferiority RCT with an internal pilot comparing the safety and effectiveness of three different surgical prophylaxis antibiotic regimens following surgery for mandible fractures. This is a multicentre trial in secondary care, involving multiple NHS OMFS units treating mandible fractures. We aim to set-up >25 sites over a 3-year trial period. We have provisional participation agreement with >50 sites and written commitment from the only UK specialist association (BAOMS) to promote, support and formally write and invite ALL OMFS units in the UK to consider participation, backing up our team for this call.

Principal Investigator

Mr Satheesh Prabhu

Contact us

Email: crndirectdeliveryteam@ouh.nhs.uk

IRAS number

338889