PRESTIGE-PTB (PREterm birth genomic investigation using whole Genome sequencing) (PRESTIGE-PTB)

Research summary

Overview and Purpose: Preterm birth (PTB) is defined as the occurrence of live birth before 37 weeks of pregnancy. Although PTB affects 10% of pregnancies worldwide and is a major global health concern, its aetiology is not fully understood. Recent studies indicate specific genetic factors are related to PTB. This nationwide multicentre cohort study aims to explore the genetic factors linked to spontaneous preterm birth (sPTB) using Whole Genome Sequencing (WGS) across diverse populations in England. The study may help us better understand and predict sPTB. Outcome measures: Whole Genome Sequencing (WGS) analysis of DNA extracted from blood sample of mothers affected by sPTB. Detailed clinical and genetic data will also be gathered. Population: Biological mothers (over 18 years old) who had a spontaneous preterm birth (between 16+0 and 36+6 weeks of gestation) in previous or current pregnancies from various ethnic backgrounds across England. Target number: We aim to collect up to 5,000 samples. Recruitment: Participants will be recruited from local hospitals and cohorts from previous ethically approved sPTB studies. Sample Collection: Venous blood (3 mL) will be collected from mothers. Duration: 36 months for participant recruitment, WGS and subsequent data analysis, commencing April 2024. In the first instance, the recruitment of women with a history of sPTB or current sPTB will be the focus at all sites, with plans to submit an amendment for the approval of study documents to enable participation of children born spontaneously preterm in the future.

Principal Investigator

Ruth Curry

Contact us

Email: osprea@wrh.ox.ac.uk

IRAS number

339022