An experimental medicine study of early tissue response in vaccination with lipid encapsulated non-amplifying mRNA in Lymph nodE single-cell Genomics in AnCestrY and ageing (LEGACY04)

Research summary

This is an open label, observational, experimental medicine study to investigate human immune responses in lymph node cells after immune challenge with a COVID-19 as an intramuscular injection. The study Participants will receive an mRNA COVID-19 booster vaccine and D0 and a seasonal influenza vaccine on Day 28,administered in the arm contralateral to the one used for the COVID vaccine. Participants will then have a fine needle aspiration (FNA) biopsy of axillary lymph nodes on both sides at two timepoints at Day 14 or 112 after the study injections. On Day 42 following the COVID-19 study vaccine injection,an additional,optional FNA with blood draw will be offered. There is a follow up visit at D182. All visits will include a blood test to check participants general health and to look at the immune response. They will be followed up for six months after the COVID-19 study injection (vaccination).

Principal Investigator

Dr Katrina Pollock

Contact us

Email: emcrf@ouh.nhs.uk

IRAS number

347668