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Master Protocol: A Phase 1b, non-randomized, open-label, repeat-dose, single center study utilizing a master protocol to investigate the safety and tolerability of multiple study interventions in advanced therapy naïve participants with moderate to severe ulcerative colitis. Sub Protocol: A Phase 1b, non-randomized, open-label, repeat-dose, single center study to investigate the safety and tolerability of aletekitug in advanced therapy naïve participants with moderate to severe ulcerative colitis. (PEGASUS)