Precision medicine Adaptive Network platform Trial in Hypoxemic acutE respiratory failuRe (PANTHER)

Research summary

A multicentre,allocation concealed,randomised,open-label Bayesian adaptive multi-arm platform trial with pre-defined triggers for efficacy and futility stopping (as compared to usual care). The trial will stratify participants by biological markers into different subphenotypes. Initial stratification will be into hyperinflammatory and hypoinflammatory subphenotypes in ARDS based on plasma biomarker profiles. Regular adaptive analyses will enable efficient identification of treatment effects within each subphenotype,stopping interventions where there is evidence of efficacy or futility,and bringing in new interventions and new subphenotypes.

Principal Investigator

Dr Stuart McKechnie

Contact us

Email: ICUResearch@ouh.nhs.uk

IRAS number

1008743