The Oxford Risk Factors And Noninvasive imaging Study

Research summary

This is a single centre, prospective cohort observational study involving patients undergoing computed tomography angiography (CTA), and patients attending outpatient clinics at the Oxford University Hospitals (OUH) NHS Trust. A total of 2500 participants will be consented to search for biomarkers in the blood that might be able to predict the risk of future cardiovascular events such as heart attack or stroke and to identify novel biomarkers which are able to predict vascular disease pathogenesis and the extent of pre--existing vascular disease. Upon consenting to take part in the study, a sample of blood will be taken from the participants and they will be asked to consent to: their medical records to be accessed annually; conduct a brief telephone questionnaire every two years; the use of clinical images obtained for clinical purposes to perform measurements of imaging biomarkers of metabolic risk and assess the severity of vascular and cardiac disease; have anthropometric measurements taken during their clinical visit that includes height, weight, and waist--hip--ratio. Those undergoing a CTA will also be asked to consent to a follow up CTA approximately 3 years later to assess for any cardio-vascular disease progression. At the end of the study, nested case-control studies will be undertaken. A unique cohort of participants will have been created that will allow the potential for subgroups to be formed and called back for future studies. Exploratory data analysis will be performed for all variables derived from this study to obtain the appropriate summary statistics. Where necessary, transformation of data will be performed for further statistical testing. Between patient relationships of plasma/imaging biomarkers will be assessed using appropriate hierarchical or multilevel data analysis.

Principal Investigator

Prof Charalambos Antoniades

Contact us

Email: cvm_nurses@cardiov.ox.ac.uk

IRAS number

164361