The UK Calciphylaxis Study

Research summary

Calciphylaxis is a rare condition which results in small arteries becoming calcified. This results in painful ulceration of the skin which in turn can result in infection and further damage to tissue. It is associated with a high mortality rate (60–80%). Consequently research into this area is important. The aims of this study are to determine the following: 1) What is the natural history of the disease? 2) What risk factors are associated with development and progression of calciphylaxis? 3) Which treatments currently in clinical practice confer a favourable outcome? 4) What are the underlying disease processes? These aims will be achieved by collecting information on medications, clinical parameters, local laboratory tests, measuring specific proteins and molecules in blood and tissue as well as studying patient’s DNA profiles.

Principal Investigator

Dr Edward John Sharples

Contact us

Email: renalandtransplanttrials@ouh.nhs.uk

IRAS number

68359