An observation study to measure biomarkers, inflammation and mediators from healthy volunteers and participants with airways disease at stable state and during acute exacerbation

Research summary

Airways diseases include asthma,chronic obstructive pulmonary disease (COPD),bronchiectasis and nasal polyps. They are common and are responsible for a large amount of morbidity,mortality and healthcare utilisation and spending. Current guidelines and treatments for airways diseases generalise treatments for large groups of patents. It is increasingly clear that this approach is no longer fit for purpose as airways diseases are much more diverse than previously thought,requiring new classification and treatment approaches. This study will look in detail at lung function,lung physiology,and inflammation (in blood,breath,sputum,airway (bronchial) samples and urine) in disease at stable state and at the start and during treatment for an exacerbation (asthma or COPD attack),or in response to other treatment changes. It is hoped that this study will add to the mechanistic understanding of underlying disease processes with a view to identifying biomarkers,distinct patterns of disease and potential treatment opportunities.

Principal Investigator

Prof Ian Pavord

Contact us

Email: severeasthmaclinic@ouh.nhs.uk

Phone: 01865227242

IRAS number

234581