Reproductive Endocrinology Oxford Study (RepOx)

Research summary

Polycystic ovarian syndrome (PCOS) is a condition where women have disrupted hormone levels, which lead to irregular or absent periods, and ovaries that have many small, fluid-filled sacs (known as follicles or cysts). It is the most common hormonal disturbance causing medical problems amongst women worldwide, and somewhere between 4-15% of women between the ages of 15 to 44 years old are estimated to have the condition. PCOS is associated with a range of medical problems including heart disease, high blood pressure, diabetes, obesity, and infertility. While pregnant women with PCOS are also more likely to suffer complications like miscarriage, pregnancy related diabetes or a liver conditions called intrahepatic cholestasis. The reason why some women develop PCOS remain poorly understood and there are no efficient treatment options in place for the disease. Here we propose a comprehensive program to figure out the underlying disease-causing effects of PCOS and medical complications known to be related to PCOS. The goal of our work is that the by increasing our understanding of why some women develop PCOS, we will be able to propose solutions for better and faster diagnosis, preventive measures and medicines for treating the disease and its complications.

Principal Investigator

Dr Ingrid Granne

Contact us

Email: osprea@wrh.ox.ac.uk

IRAS number

302159