Early vasopressors in Sepsis (EVIS)

Research summary

Sepsis is a life-threatening reaction to an infection. It happens when the immune system overreacts to an infection and starts to damage the body’s tissues and organs. The aim of this research study is to compare the effectiveness of giving a vasopressor drug (norepinephrine) against a Balanced Crystalloid both of which are given via a drip in the arm. Vasopressors work by increasing the blood pressure which allows a better blood flow to internal organs. We plan to see which is better and to see if they have a role in improving a patient’s recovery time, reducing complications, the length of time they stay in hospital and longer term poor health. Based on research that has already been done, we believe treating patients with vasopressors when they arrive in the Emergency Department, may have potential advantages over the standard fluids used today. However, the evidence is not clear and that is why we are doing this research.

Principal Investigator

Dr Deon Louw

Contact us

Email: sally.beer@ouh.nhs.uk

IRAS number

307862