This is a global open-label, randomized, multicenter, interventional study in pregnant participants with a prior FNAIT-affected pregnancy to assess the efficacy, safety, tolerability, PK, PD, and immunogenicity of nipocalimab or IVIG. ‘IVIG’ throughout the protocol will be referring to the IVIG with or without prednisone regimen adapted from Bussel et al (Bussel 2021). The studywill target participants whose current pregnancies are affected by HPA-1a and/or HPA-5b incompatibility. Maternal participants with alloantibodies against both HPA-1a and HPA-5b will be categorized under HPA-1a ...

GO TO STUDY

Children and young people (CYP) with problems with sore joints called Juvenile idiopathic Arthritis (JIA) or problems with their immune system (rheumatological issues) have a range of complaints, such as painful, stiff joints. These problems come and go and can stop CYP attending school. In adulthood, symptoms may affect what job they are able to do. CYP often need to take medications with severe side effects. CYP are usually watched closely to ensure that their medications are working and side ...

GO TO STUDY

Ketone bodies are fat-derived fuels used by tissues for energy when glucose availability is limited, such as during fasting. In people with diabetes, various factors can trigger a build-up of ketones in the blood (ketosis), including inadequate insulin administration, infection, continuous subcutaneous insulin infusion pump failure, and certain medications. This can lead to a life-threatening medical emergency called Diabetic Ketoacidosis (DKA). Patients with heart failure or chronic kidney disease also have an increased risk of ketosis due to the use ...

GO TO STUDY

This research aims to establish the number of patients coming to Emergency Departments (EDs) with issues relating to mental health, alcohol or drugs, or in some form of psychological distress, including those for whom this was not the main reason for attending ED. We will collect anonymous information on age, gender, ethnicity, when and how they came to the ED, where and how they are cared for whilst in the ED, and what happens to them afterwards. With this information we hope to build ...

GO TO STUDY

Crowding in emergency departments is a recognised public health challenge. Crowding leads to patient care being delivered in areas not originally designed for this use known as ‘escalation areas’. Although a formal definition of an escalation area does not exist, examples include ambulance waiting areas, repurposed clinical areas outside the usual emergency department footprint and non-clinical areas such as hospital corridors. There is a lack of data about how many patients are receiving care in such environments, and what impact ...

GO TO STUDY

As people live longer, understanding how cognitive abilities change with age is increasingly important. Cognitive abilities generally decline slowly as we age, but in some cases, this decline can be more pronounced. Mild Cognitive Impairment (MCI) is a condition where cognitive decline is greater than expected for someone's age but does not severely impact daily activities. This differentiates MCI from Alzheimer's dementia, a more serious condition involving significant brain cell death parallelled by cognitive and behavioural dysfunction. While distinct, MCI ...

GO TO STUDY

Transcatheter aortic valve implantation (TAVI) is a key-hole technique to replace a faulty (narrowed and/or leaking) aortic heart valve. The replacement aortic valve is delivered to the heart through tubes inserted in a main artery (usually the artery in the groin). Over the past 15 years TAVI has rapidly grown and has taken over from open-heart surgery (surgical aortic valve replacement (SAVR)) to become the most commonly used technique for aortic heart valve replacement. Although TAVI is a safe and effective ...

GO TO STUDY

Three main arrhythmia syndrome phenotypes currently included in the Genomics England (GEL) 100K Genomes Project are: long QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPVT). These disorders are responsible for much of unexplained sudden cardiac death (SCD), an important cause of death in Western countries. A substantial proportion of arrhythmia syndromes are presumed to be due to rare and common genetic variation, however their genetics are variably understood at present and no condition has been ascertained completely. We ...

GO TO STUDY

We are testing a drug called ginisortamab that blocks a protein called gremlin-1. Gremlin-1 is mainly found outside cancer cells and stops the function of other proteins called bone morphogenetic proteins (BMPs). BMP proteins work by suppressing cancer cells as they occur but in cancer, this mechanism has often been switched off. Blocking gremlin-1 with ginisortamab will allow BMP protein function, and we hope this will change the way the cancer cells develop, making them more sensitive to chemotherapy. We are testing ginisortamab ...

GO TO STUDY

Research question In patients who have a high-risk primary cutaneous squamous cell carcinoma (HR-cSCC) surgically excised with clear margins,is adjuvant radiotherapy plus close clinical follow-up superior in reducing the risk of loco-regional recurrence compared with close clinical follow-up alone,and if so,is it cost-effective? Background cSCC is the second most common skin cancer in the UK,with annual incidence exceeding 52,000,increasing by 6% p.a (1,2). Treatment,usually surgery,is curative in 95% (3,4). However,5% of patients develop loco-regional recurrence (LRR) which causes 75% of cSCCspecific mortality,substantial morbidity and reduced quality of life (QoL) ...

GO TO STUDY