The Registry of Pulmonary Hypertension in Neonates (RePHyNe) is a prospective global multicentre observational cohort data collection study designed to collect routine clinical data including diagnostic tests and treatments delivered as part of patients’ clinical care. Participants will be recruited by clinicians working in neonatal and paediatric intensive care units who routinely provide care for neonates and young infants with pulmonary hypertension < 3 months of age,corrected for prematurity. Written informed consent will be obtained from parents/guardians. Participants will undergo ...

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Research question: Does post-operative radiotherapy following surgery for pathological fractures improve pain and quality of life? Background: Approximately 70% of people with advanced breast and prostate cancer develop bone metastases, causing ‘pathological’ fractures requiring surgery to stabilise or replace the affected bone. Following surgery, patients usually receive radiotherapy (RT). Despite widespread use, no high-quality evidence exists that post-operative RT improves pain, quality of life nor reduces the risk of re-operation. RT has side-effects, requires additional hospital visits and scans, can delay other effective ...

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This is a post-authorisation study evaluating the effectiveness and safety of belzutifan in routine clinical practice. It will include Adult (> = 18 years of age) patients with von Hippel-Lindau (VHL) disease for which a decision has been made by the treating physician to initiate belzutifan treatment. The study aims to enroll up to 100 patients with VHL disease-associated renal cell carcinoma (RCC) and/or central nervous system (CNS) hemangioblastoma. This includes approximately 40 patients with VHL disease-associated RCC and approximately ...

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Sometimes, after a broken hand or wrist, surgery is needed to fix the bones. This is routinely performed in the NHS and is usually the case if the bones have fallen out of place. During the surgery, doctors will use metal wires to hold the bones in the right place while they heal. Once the bones have healed, the wires are then removed. There are currently no reliable studies to tell us if these wires are better left sticking out ...

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Each year in the UK at least 60,000 patients are diagnosed with heart failure. Coronary artery disease (narrowing of the blood vessels supplying the heart) is the most common cause of heart failure. Invasive coronary angiography is often done as the first line test to identify coronary artery. However, we know from work with our patient and public involvement groups that most patients would prefer to avoid invasive coronary angiography if possible. The aim of this trial is to establish if ...

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Up to one third of patients undergoing coronary angiography have moderate to severe calcium build-up in their heart arteries. As the population ages, the number of patients with calcified coronary lesions requiring complex percutaneous coronary intervention (PCI) is expected to increase. Calcified arteries make procedures more difficult, often resulting in longer treatment times and poorer outcomes. To improve these outcomes, it is important to prepare the artery by modifying the calcium before placing a stent. Several approved devices are available on ...

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This cognitive function decline study comparing haemodialysis (HD) patients with peritoneal dialysis (PD) patients will be conducted using the DOPPS and PDOPPS (Peritoneal Dialysis Outcomes and Practice Patterns Study) core protocols and infrastructures in the UK. This will allow comparison of change of cognitive function in incident HD and PD patients over time, with the hypothesis that PD is associated with less cognitive impairment (CI) and slower progression of CI than HD.

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Hepatitis C Virus currently infects more than 50 million people worldwide and remains a major cause of liver cancer, liver failure and death. This study is the first stage in the development of a human challenge model for hepatitis C Virus infection (HCV), which is needed to test new vaccines that will prevent HCV infection. The purpose of this study is to collect blood from people living with a hepatitis C virus (HCV) infection from sites in the UK which ...

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This is a multi-centre,first-in-human Phase I/IIa dose escalation and dose expansion trial in participants with haematological malignancies. NVG-222 is an autoregulating,half-life extended bispecific ROR1-directed TCE. NVG- 222 will be the first agent to be tested in the clinic that includes an AR mechanism based on granzyme B cleavage. The addition of an IgG1 Fc domain to NVG-222 provides for an extended half-life,allowing a more convenient Q2W dosing regimen compared with continuous IV infusions required for a previous agent NVG-111. The ...

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This application is for a health economics analysis alongside the ongoing WHEAT Trial (IRAS 309894). Babies born prematurely are at risk of necrotising enterocolitis (NEC), a serious gut disease that causes over 200 deaths yearly in the UK – about 1 in 20 of all child deaths. Babies who survive NEC often face long-term gut and brain damage. Premature babies are fed milk every few hours and often need blood transfusions for anaemia (low red blood cells). Some doctors worry that ...

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