The aim of the IBHO BioResource is to research the social and biological causes,and impacts,of a broad range of health conditions and illnesses in people from Black communities in the United Kingdom (UK). These include disorders that affect people from Black communities at increased rates,such as diabetes and pregnancy/childbirth complications,but also conditions that almost exclusively affect those from Black communities such as sickle cell disease. The IBHO Bioresource is also designed to examine some conditions such as anxiety,depression,and dermatological problems,about ...

GO TO STUDY

Every year over 15,800 people are diagnosed with gullet (oesophageal) or stomach cancer and over 12,300 deaths are reported from both cancers in the UK. Currently, most gullet or stomach cancer patients are treated with surgery with or without additional chemo- or radio-therapy. Recently, there have been improvements in survival from these cancers, due to better therapies. However, around two-thirds of patients treated with surgery, the cancer will return within three years and they will ultimately die from this. There ...

GO TO STUDY

Type 1 diabetes (T1D) is an autoimmune condition, and one of the most common, chronic conditions of childhood. Three stages of T1D are recognised, with stage 1 and 2 T1D characterised by autoimmunity (presence of two or more diabetes antibodies) where individuals are pre-symptomatic. Stage 3 T1D is the classical symptomatic presentation, when insulin commencement is necessary. Almost all children with two or more T1D antibodies, will develop T1D in their lifetime. Earlier detection of T1D will identify individuals who ...

GO TO STUDY

The purpose of this study is to evaluate the efficacy of glofitamab monotherapy compared with an investigator’s choice of either rituximab plus bendamustine (BR), or lenalidomide with rituximab (R-Len) in patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) as measured by Blinded Independent Review Committee (BIRC) assessed progression-free survival (PFS). Participants will be randomized in a 1:1 ratio to receive either glofitamab as a single agent or an investigator’s choice between BR or R-Len. Approximately half of the patients ...

GO TO STUDY

1 in 7 babies require neonatal care. During their time in hospital their vital signs (such as heart rate, breathing rate and oxygen saturation) are continuously monitored as part of standard care. Many factors lead to changes in vital signs, for example, medical procedures such as blood tests can result in brief increases in heart rate. Medication can also alter vital signs, either as an intended effect or as a side effect. However, different infants will respond in different ways ...

GO TO STUDY

Women with disease-causing gene changes (faults/mutations) in BRCA1, BRCA2, PALB2, CHEK2 and ATM are at an increased risk of developing certain types of cancer - specifically breast (all genes) and epithelial ovarian cancer (BRCA1, BRCA2, PALB2 only). At present, the risk estimates given by most health practitioners to women are broad (e.g. 35-85% lifetime risk of breast cancer for BRCA1 and BRCA2) and are not personalised. This can make it difficult for women to make informed decisions regarding risk ...

GO TO STUDY

Primary spontaneous pneumothorax (PSP) is an abnormal collection of air in the space between the lung and the chest wall, causing collapse of the lung. This type of pneumothorax is called primary, as it happens in patients with no underlying lung disease, and spontaneous, as it occurs without injury. Previous work by our group shows that 3,000 patients a year need admission to hospital to treat a PSP. Currently, patients with symptoms are treated by draining the air through a ...

GO TO STUDY

The median FiO2 using 3 high flow nasal oxygen flow rates(30,45,60 litres per minute) required to maintain an oxygen saturation =94 % and respiratory rate =30 in patients with acute respiratory failure.

GO TO STUDY

AIM: To assess whether movement minimisation is no worse than triple spinal immobilisation for patients who have may have or are suspected of having a spinal injury in the pre-hospital and emergency setting. BACKGROUND: Spinal cord damage often occurs as a result of road traffic crashes, sports injury or falls in frail people. Although rare, it can dramatically affect quality of life and lead to long term disability or death. In the UK, when a potential traumatic spinal injury occurs, current ...

GO TO STUDY

Individuals with rare genetic conditions are an underrepresented group in research, and this leads to health inequalities within this clinical group. Engagement with stakeholder groups (Unique: Understanding Rare Chromosome and Gene Disorders) and early research findings indicate that individuals with certain rare genetic conditions are highly vulnerable to childhood eating difficulties and eating disorders. This has been further exacerbated by the COVID-19 pandemic. Individuals with 16p11.2 deletion syndrome are at high risk of obesity and emotional over-eating, whereas patients with 16p11.2 duplication syndrome tend to ...

GO TO STUDY