A coronary artery bypass graft (CABG) is a surgical procedure used to treat coronary heart disease. It diverts blood around narrowed or clogged parts of the major arteries to improve blood flow and oxygen supply to the heart. Like all organs in the body, the heart needs a constant supply of blood which comes through arteries called coronaries. Over time, these arteries can become narrowed and hardened by the build-up of fatty deposits called atherosclerosis plaques. CABG involves taking a blood ...

GO TO STUDY

BEACON is a UK based,multicentre,1 year,assessor-blind,parallel group,superiority,randomised controlled trial. The primary aim of the trial is to determine the effectiveness of methotrexate and dupilumab compared with ciclosporin. The primary endpoint is change in objective disease severity at 6 months,presented as mean absolute change from baseline,using the Eczema Area Severity Index (EASI,blinded assessment). Patients will be randomised 1:1:1 to methotrexate,dupilumab or ciclosporin for 6 months (optional dose increase at 3 months for those on methotrexate or ciclosporin as per clinical practice). ...

GO TO STUDY

Adverse drug reactions (ADR's) are a common cause of drug-related morbidity and may account for about 6.5% of all hospital admissions. Our research shows that ADRs cost the NHS at least £700 million per annum. A meta-analysis of studies performed in the USA has shown that ADRs may be the fourth commonest cause of death. ADRs are also a significant impediment to drug development, and a significant cause of drug withdrawal. Prevention of adverse drug reactions is important for all health-care ...

GO TO STUDY

Previous studies have shown that Continuous Glucose Monitoring (CGM) improves maternal glucose, reduces neonatal admissions and is clinically and cost-effective in type 1 diabetes (T1D) pregnancy, and as a result CGM is now standard care in T1D pregnancy. However, there are no well-designed adequately powered trials to compare CGM and standard care monitoring of blood glucose in type 2 diabetes (T2D) pregnancy. The purpose of this study is to examine whether using CGM improves glucose levels in pregnant women with ...

GO TO STUDY

The primary objectives for this trial are related to each of the trial questions. For the chemotherapy questions,the objectives are to determine: • whether outcome in newly diagnosed metastatic ES patients can be improved with the addition of regorafenib to the standard backbone chemotherapy VDC/IE when compared with VDC/IE alone (Randomisation A) •whether the addition of 6 cycles of maintenance chemotherapy of vinorelbine and cyclophosphamide improves the outcome for patients. (Randomisation C) For the radiotherapy questions,the objectives are to determine: • whether dose escalation of radiotherapy improves ...

GO TO STUDY

This is a randomized, active-controlled, parallel-group, multi-site, open-label study of nemtabrutinib in participants with CLL/SLL who have not received any prior therapy. After providing documented informed consent, suitable candidates will be screened to assess whether they meet all study eligibility criteria. The study will be conducted in conformance with GCP. Approximately 1200 eligible participants will be enrolled and randomly assigned in a 1:1 ratio to 1 of the 2 treatment groups: • Experimental Group – nemtabrutinib • Comparator Group – investigator’s choice ...

GO TO STUDY

Management of a strict, gluten-free diet is essential for children and young people (CYP) with coeliac disease, but this can negatively impact psychological wellbeing and quality of life. Despite calls from families, clinicians and researchers, psychological support is not routinely available for these families. This is surprising, given the mounting evidence for self-help psychological resources (e.g. guided self-help books, websites) in supporting the self-management, and wellbeing, of a range of long-term conditions. This project proposes to adapt existing psychological interventions, ...

GO TO STUDY

This proposed study is a prospective cohort study of young adult patients (18-54 years) with ischaemic stroke or intracerebral haemorrhage in England. Study participants will be recruited through the established 15 NIHR Clinical Research Network (CRN). CRN employed research nurses together with the clinical team at each participating centre will screen,identify and complete a questionnaire to collect information on history of traditional and emerging risk factors with eligible patients and also to collect investigation results related to the stroke from their ...

GO TO STUDY

The objectives of the NHS Cancer Vaccine Launchpad (CVLP) are to: 1. Identify cancer patients undergoing resection or biopsy of their tumours who could be eligible for personalised mRNA therapies such as cancer vaccines. 2. Create a pathway for collection and transfer of tumour samples, blood samples and pseudonymised clinical data during routine NHS care. 3. Send samples for DNA extraction, molecular analysis and sequencing initially in partnership with industry (Phase 1) and later to be performed by the NHS Genomic Medicine ...

GO TO STUDY

Neuromuscular Diseases (NMDs) affect at least 17 million children and adults globally. They cause either premature death, or are chronic diseases causing lifelong disability with economic impact. They include many different disorders affecting muscle and nerve function, and account for approximately 25% of all non-infectious neurological diseases. Most NMDs are caused by changes to single genes. Identifying these precisely and understanding how they cause disease has already led to some important advances in patient management plans and the development of new ...

GO TO STUDY