Throughout the 20th century, the global incidence of pancreatic cancer has steadily increased. It is currently the 4th most common cause of cancer death in Western societies. In the period 1930-1970, the rate of mortality associated with pancreatic cancer doubled in the UK and, as the incidence of the disease continues to rise, it is expected to become the 2nd most common cause of cancer death within a decade. Pancreatic cancer is often diagnosed late and therapy options for patients ...

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Type 1 diabetes (T1D) is a chronic disease affecting around 17 million people worldwide. The disease may present at any age, but most typically develops in early life with a peak around puberty. The scientific insights to the triggering events, disease susceptibility, and subsequent pathophysiological events leading to a failing beta-cell function and beta cell loss (beta cells are found in the pancreas produce insulin)in human T1D are quite limited and disease modifying therapeutic approaches to address T1D ...

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UCL to act as the managing research organisation and central coordinating body for the study and study sponsor. The study (described below) will be active in approximately 12 countries including the UK, USA, Canada, Australia, Germany, Italy and Spain. HDClarity will seek to enroll approximately 600 research participants - 500 of whom will be at different stages of Huntington's disease (HD) and 100 healthy controls. All participants will attend a screening and sampling visit. During the screening visit, medical history, ...

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The aim of our study is to personalise management of high blood pressure for young adults between the ages of 18 to 40 years old. In the UK, at least 1 in 17 adults below the age of 40 have high blood pressure. Controlling the blood pressure in young adults can be a challenge for doctors because information on the management of high blood pressure is mainly obtained from older people. To overcome this challenge, we will study clinical data, ...

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The purpose of this study is to investigate how altered cellular processes may affect both the function and the structural remodelling of the human heart muscle (myocardial). Oxidative stress, is an imbalance between the production of free radicals (a very reactive molecule that looks to other compounds to gain stability) and the body’s ability to produce enough antioxidants to neutralise them. More research is needed to gain a better understanding in how this imbalance may influence the heart and its ...

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The purpose of this study is to investigate the mechanisms of cardiac fibrosis through the identification of markers involved in the pathogenesis of cardiac fibrosis. Cardiac fibrosis is accompanying most of the cardiac diseases and is an unsolved clinical problem. We are going to recruit up to 250 patients undergoing elective cardiac surgery in the John Radcliffe hospital in Oxford. This study is an observational lab-based study. The blood samples will be assessed for new markers derived from the cardiac tissue ...

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The immune system is a network of cells, tissues and organs that work together to defend the body against infection. Over 70% of the immune system is based in the gastrointestinal tract where it plays a major role in a complex interaction with trillions of microbes to maintain health. The breakdown of this interaction leads to diseases such as inflammatory bowel disease (IBD) and contributes to many others including colorectal cancer. We work on the nature of intestinal immune ...

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This is a research study to test a new investigational drug called NUC-7738. NUC-7738 belongs to a new class of anti-cancer agents called ProTides that are specifically designed to transform some of the most widely prescribed chemotherapy agents, nucleoside analogues, into more effective and safer medicines. The primary objective of this study is to investigate the safety and tolerability of NUC-7738 in subjects with solid tumours or lymphomas. This is a first-in-man study. The study is funded by NuCANA plc, an ...

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Neuropathic (nerve related) pain occurs in a significant proportion of patients with a disease affecting the nervous system (neuropathy). The exact pathomechanisms of neuropathic pain and why only a subgroup develop neuropathic pain remains elusive. Over the past decade, experimental nerve injury models have highlighted the importance of neuroinflammation in the generation of neuropathic pain. Specifically, peripheral nerve injuries lead to an intraneural infiltration and activation of immune cells such as macrophages, T-Lymphocytes or dendritic cells. These cells are known ...

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The purpose of this study is to investigate the link between inflammation (an important process in heart diseases) and atrial fibrillation (a very common rhythm disorder). We are going to recruit up to 360 patients undergoing procedure of ablation (up to 160 patients) or cardioversion (up to 200 patients) in the John Radcliffe hospital in Oxford. Both procedures are commonly used in treatment of atrial fibrillation. This study is a lab-based observational study which will involve analysing of the peripheral ...

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