Working with the NIHR Bioresource, we are proposing to develop a centralised national recallable bioresource of 55,000 patients with Crohn's disease or ulcerative colitis (collectively inflammatory bowel disease / IBD) to support scientific and clinical IBD research. Key features of IBD Bioresource:1. DNA and serum + clinical and genetic data from 55,000 IBD patients recruited UKwide stored in a central biorepository funded by NIHR Bioresource 2. 1000 newly diagnosed IBD patients. Detailed samples unconfounded by treatment or surgery, plus followup ...

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Colorectal cancer (CRC) remains an important cause of morbidity and mortality. Identifying those at higher risk is important in targeting preventive measures, such as screening colonoscopy, to those most likely to benefit. Much of the risk of CRC and its precursor lesions (mostly polyps) is genetic, but a great deal of the heritability of CRC remains unexplained. Some of the remaining genetic risk probably results from rare genes with large effects, some from uncommon genetic variants with moderate effects and ...

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Changes in the brain may precede symptoms of Alzheimer’s dementia by many years if not decades. Such changes indicate that a very early Alzheimer’s disease process has started well before people start developing the typical symptoms of dementia such as memory loss – this is known as pre-clinical Alzheimer’s disease. Individuals who are beginning to experience impaired memory as a consequence of this disease process, yet are functionally independent and not showing signs of dementia, are in a prodromal Alzheimer’s ...

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Biomede is an international, multicenter, randomised, open-label, adaptive, phase II trial of treatment for Diffuse Intrinsic Pontine Glioma (DIPG). This trial mandates a biopsy of the tumour to obtain the biological profile of the tumour. The allocation of treatment in each patient will be based on the specific biological tumour profile. Recruitment target is 80 patients in the UK, 250 in the EU with DIPG over 4 years. The initial agents to be studied based on biomarkers profile are; Dasatinib, ...

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This application is to gather and analyse patient data using the PQIP Database. PQIP will measure complications after major planned surgery and seek to improve these outcomes through feedback of data to clinicians. A REC/CAG application for the PQIP Database has already received a favourable opinion. This analysis will answer important research questions about variation in quality of care in major surgery. We expect that this substantial collaborative work will lead to valuable insights regarding the ways in which hospitals use ...

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The aim of the study is to evaluate the accuracy of blood glucose monitoring systems using capillary or venous blood samples from patients with diabetes and comparing the results to glucose readings obtained from the Yellow Springs Instrument (YSI) analyser. It is an ongoing study which is divided into separate 'study events' which are conducted on an ongoing basis. Participation for the patient will consist of one visit to the study site. The duration of the visit is expected to ...

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This is a feasibility study of the use of a novel technique called ‘InspiWave’ (Inspired Sinewave Technique) to measure heart and lung function in adult patients in critical care. The preliminary work was funded by the EPSRC for early engineering development and the NIHR for clinical translation. The Farmery Group has been developing this technology and has undertaken successful tests in animal models and in well participants. The ultimate aim of the wider project is to develop ...

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Adipose (fat) tissue is now considered to be a key player in the regulation of cardiovascular health. Increased fat accumulation, genetic variability in the expression of signalling molecules in fat as well as changes in the nature of the fat tissue all contribute to an individual’s cardiovascular risk. This is a prospective cohort study involving patients presenting with either a heart attack of recent onset (< 24 hours) or stable coronary artery disease, who are scheduled for intervention (elective percutaneous ...

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Cancer of the large bowel (colorectal cancer) is common in the general population and the lifetime risk for someone living in the UK is 1 in 17. Whilst modern surgery, radiotherapy and chemotherapy treatments have impacted beneficially on survival outcome, many patients still die from their disease. Hence, there is a pressing need to understand the causes of colorectal cancer and to intervene early. Colorectal cancer under the age of 40 years of age is particularly rare, with less than 1.2% of all ...

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Macular Telangiectasia (MacTel) type 2 is a disease of the retina, the light-sensing tissue at the back of the eye. MacTel type 2 leads to a gradual deterioration of central vision,which usually becomes noticeable in people around 40 to 60 years of age.The gradual loss of central vision experienced because of MacTel type 2 has a significant impact on quality of life, due to central vision being required for tasks that require sharp vision,e.g. reading and driving. MacTel type 2 ...

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