The Preterm Clinical Network Cohort Research Programme (PCN-CRP) is a series of studies aiming to reduce preterm birth and the problems it can cause. These studies will investigate tests to predict preterm birth, treatments to prevent it, and how to improve outcomes for babies and women’s experience of care. The programme will be carried out in partnership with Tommy’s National Centre for Preterm Birth Research and the UK Preterm Clinical Network (UKPCN). This is a network of ...

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Angina with Non-Obstructive Coronary Arteries (ANOCA) is a common condition where patients have chest pain despite no major blockages in their heart arteries. ANOCA is caused by problems in the smaller vessels, known as coronary microvascular dysfunction (CMD), or by sudden narrowing of the arteries, called vasospasm. CMD can occur through two main mechanisms: endothelium-dependent mechanisms, where the inner lining of the vessels (the endothelium) doesn’t properly control the widening of the blood vessels or increase in blood flow when ...

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The Registry of Pulmonary Hypertension in Neonates (RePHyNe) is a prospective global multicentre observational cohort data collection study designed to collect routine clinical data including diagnostic tests and treatments delivered as part of patients’ clinical care. Participants will be recruited by clinicians working in neonatal and paediatric intensive care units who routinely provide care for neonates and young infants with pulmonary hypertension < 3 months of age,corrected for prematurity. Written informed consent will be obtained from parents/guardians. Participants will undergo ...

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In the United Kingdom each year about 7000 babies are born very preterm and need specialist neonatal care. Necrotising enterocolitis (NEC) is a serious gut condition affecting 1 out of 10 extremely preterm babies (those who are born before 28 completed weeks of pregnancy). Babies with NEC commonly require surgery and, of these, one out of three unfortunately will not survive. About half of NEC survivors have long-term neurodevelopmental problems like cerebral palsy or learning difficulties. Risk factors for NEC ...

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Certain anti-seizure medications (ASMs) are known to carry a teratogenic risk and are associated with higher rates of impaired physical and neurodevelopmental outcomes in the children of women with epilepsy. However, there remains a considerable gap in our current knowledge regarding the risk/safety profile of the majority of ASMs when used during pregnancy, including commonly prescribed ASMs such as lamotrigine and levetiracetam. We will investigate the health and development of children who were exposed in utero to ASMs and whose ...

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While blood transfusions save lives in the neonatal critical care setting, there is increasing awareness that transfusion of blood products is an independent predictor of adverse outcome. Infants in a neonatal intensive care unit (NICU) are among the most frequently transfused patients with the incidence and severity of major neonatal morbidities known to correlate with the number and volume of red blood cell (RBC) transfusions they receive. The spectrum of post-transfusion effects on organs and tissues which manifest ...

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This is a double-blind, randomised, multicentre, placebo-controlled, comparative phase II efficacy trial. The trial will be conducted with two treatment groups in the form of a parallel group comparison and will serve to compare oral treatment with daily doses of 75 mg [25 mg three times a day (TID)] and potentially 30 mg (10 mg TID) of ZED1227 vs placebo for treatment of celiac disease. The screening period will be up to 4 weeks, followed by a 3-week single-blind placebo run-in ...

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Study Aim To investigate how often diagnostic delays or errors of carbon monoxide (CO) poisoning happen in Emergency Departments (EDs) in UK. Background Carbon monoxide (CO) poisoning is a common but often overlooked medical emergency. CO poisoning occurs when people are exposed to this odourless and invisible gas, often produced by faulty heaters, car engines, or other fuel-burning appliances. Symptoms like headaches, dizziness, or nausea can be confused with other illnesses, making diagnosis difficult. If not recognised quickly, ...

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Multiple sclerosis (MS) affects more than 130,000 people in the UK and over 2.5 million people worldwide. MS often begins with a relapsing-remitting phase (RRMS). However,over time,many people with RRMS start to find that they no longer recover after a flare-up (also known as a relapse) and get steadily worse,resulting in increased disability. This is known as secondary progressive MS (SPMS). A smaller number of people experience a gradual decline from the beginning,known as primary progressive MS (PPMS). SPMS and ...

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Research question: Does post-operative radiotherapy following surgery for pathological fractures improve pain and quality of life? Background: Approximately 70% of people with advanced breast and prostate cancer develop bone metastases, causing ‘pathological’ fractures requiring surgery to stabilise or replace the affected bone. Following surgery, patients usually receive radiotherapy (RT). Despite widespread use, no high-quality evidence exists that post-operative RT improves pain, quality of life nor reduces the risk of re-operation. RT has side-effects, requires additional hospital visits and scans, can delay other effective ...

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