In the UK there are 72,000 hip fractures annually. One common complication after hip fracture treatment is a blood clot, affecting two in every five patients. The best treatments to reduce blood clots, and the complications associated with them are uncertain. In people with hip fractures the main aim of these treatments is to reduce mortality. NICE has issued a recommendation to address this specific research question. Current trials are too small to measure differences in mortality and have used ...

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Bleeding from the gut can be life-threatening and can lead to hospitalisation, serious complications or death. Traditionally, surgery has been used to stop the bleeding, but this can carry significant risks. Interventional radiology plays an important role in diagnosis and treatment. Small catheters can be placed by pinhole techniques and directed by X-rays to examine the blood vessels and find the source of bleeding. If a bleeding source is identified, an embolisation procedure can be performed to block the affected blood vessel. During embolisation, the doctor ...

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COVHIC003 is a controlled human infection study in which healthy adults aged 18-50 previously vaccinated with a COVID-19 vaccine will be administered a SARS-CoV-2 Omicron subvariant given by drops in the nose. The aim is to achieve breakthrough upper-respiratory infection in a proportion of volunteers with mild or no illness, providing information on the course of Omicron infection and the immune response in vaccinated people. This study will establish an optimised challenge dose and model using a recent Omicron strain ...

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This randomised phase III trial will determine whether adjuvant RTX increases remission rate when compared to standard ATD treatment in young people with GD. The primary endpoint will be a comparison of the proportion of subjects in remission at 3 years (subjects not requiring ATD for 12 months) following a 2-year course of ATD +/- RTX in the two treatment arms. Secondary outcomes include an analysis of lymphocyte subsets,cytokines,chemokines and immunological and genetic markers of B lymphocyte activity compared to outcome as well as quality ...

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Why is the study being done? We want to find out if a blood test that detects circulating microRNA (miRNA) could be used to detect if a patient’s cancer has returned. Testicular seminoma is one of the commonest cancers in young men; ovarian dysgerminoma is rarer, typically affecting teenagers/young adults. Stage I disease is well managed with surgery followed by surveillance using imaging (CT or MRI, or ultrasound for younger dysgerminoma patients) but this is a burden for patients, may expose them ...

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We will aim to see whether a device that helps with breathing exercises can improve recovery for older people when taken to hospital with broken ribs. Broken ribs are painful and can make it harder to take a deep breath or cough. Over half of older people with broken ribs then develop problems, like chest infections. We think that a device called an ‘incentive spirometer’ (IS) which helps people take a deeper breath, may help to prevent these problems. These ...

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Intellectual disability (ID) affects a person’s ability to learn, reason, and manage daily tasks; ID is common in people with Dravet syndrome (DS), Lennox-Gastaut syndrome (LGS) and tuberous sclerosis complex (TSC), which are forms of epilepsy. Challenging behaviour refers to actions that are extreme or difficult to manage, potentially putting the person or others at risk and making it difficult to take part in everyday activities. People with ID and epilepsy are more likely to show challenging behaviours. These behavioural ...

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Preparing adults for surgery improves recovery and shortens hospital stays. We want to know if the same is true for children. Does preparing children for hip, leg and foot surgery help them recover faster, reduce their time in hospital, and save the NHS money? Why are we doing this research? 1. We asked over 400 children, parents/guardians and doctors. Preparing children for surgery was a top research priority, especially if it could speed up recovery. 2.Shorter hospital stays could reduce burden on NHS ...

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This trial will determine future guideline recommendations for patients with bronchiectasis. P. aeruginosa is difficult to treat and patients are at high risk of hospitalization, lung function decline and death (4,5) Preventing long term P. aeruginosa infection is therefore highly desirable. The NHS spends more than £30m annually on managing bronchiectasis (8). A US study comparing healthcare costs before and after acquisition of P. aeruginosa reported an 87% increase from $36,213 to $67,764 annually per patient (10,11). Determining the efficacy ...

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Each year, many babies are born prematurely (before 37 weeks of pregnancy). Babies born early are at higher risk of later difficulties, particularly with language development. During pregnancy, babies begin to hear sounds from around 25 weeks. Inside the womb, sounds are naturally softened and filtered by the mother’s body. This means that babies mainly hear the rhythm and melody of speech, rather than clear individual words or sounds. Hearing these speech patterns before birth helps prepare babies’ brains for learning ...

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