Bronchiectasis affects around 300,000 people in the UK, according to British Lung Foundation research. Hospital admissions due to bronchiectasis cost the NHS around £40 M per year. International guidelines recommend that patients receive intravenous antibiotics for 14 days if they are particularly unwell, have an infection with resistant organisms, or if oral antibiotics are ineffective. The duration is based on expert advice but there have not been any randomised placebo controlled trials telling us what length of course is best. Treating ...

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Chronic limb-threatening ischaemia (CLTI) is an advanced form of poor blood circulation in the legs which can lead to severe pain, wounds that do not heal, and amputation. Most patients with CLTI have severe calcium build-up in their blood vessels, which stiffens the vessel wall and makes it difficult to open narrowed arteries using standard endovascular treatments such as balloons or stents. Orbital atherectomy (OA) is a vessel preparation technique that uses sanding and pulsatile mechanical forces to modify calcified ...

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Heart attacks and other forms of acute coronary syndrome (ACS) occur when blood flow to the heart is suddenly blocked by a blood clot or a narrowed artery. These events remain one of the leading causes of death worldwide. The standard treatment is percutaneous coronary intervention (PCI) — a minimally invasive procedure where a small metal tube, called a stent, is placed to keep the artery open. Traditionally, doctors rely on X-ray images (angiography) to guide stent placement. However, these images ...

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In the UK there are 72,000 hip fractures annually. One common complication after hip fracture treatment is a blood clot, affecting two in every five patients. The best treatments to reduce blood clots, and the complications associated with them are uncertain. In people with hip fractures the main aim of these treatments is to reduce mortality. NICE has issued a recommendation to address this specific research question. Current trials are too small to measure differences in mortality and have used ...

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Bleeding from the gut can be life-threatening and can lead to hospitalisation, serious complications or death. Traditionally, surgery has been used to stop the bleeding, but this can carry significant risks. Interventional radiology plays an important role in diagnosis and treatment. Small catheters can be placed by pinhole techniques and directed by X-rays to examine the blood vessels and find the source of bleeding. If a bleeding source is identified, an embolisation procedure can be performed to block the affected blood vessel. During embolisation, the doctor ...

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COVHIC003 is a controlled human infection study in which healthy adults aged 18-50 previously vaccinated with a COVID-19 vaccine will be administered a SARS-CoV-2 Omicron subvariant given by drops in the nose. The aim is to achieve breakthrough upper-respiratory infection in a proportion of volunteers with mild or no illness, providing information on the course of Omicron infection and the immune response in vaccinated people. This study will establish an optimised challenge dose and model using a recent Omicron strain ...

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This randomised phase III trial will determine whether adjuvant RTX increases remission rate when compared to standard ATD treatment in young people with GD. The primary endpoint will be a comparison of the proportion of subjects in remission at 3 years (subjects not requiring ATD for 12 months) following a 2-year course of ATD +/- RTX in the two treatment arms. Secondary outcomes include an analysis of lymphocyte subsets,cytokines,chemokines and immunological and genetic markers of B lymphocyte activity compared to outcome as well as quality ...

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TACTIC is a prospective, investigator-initiated, multicenter, randomized, controlled, open-label, PMCF clinical study. The medical device used in the study is the Indigo™ CAT RX Aspiration Catheters and Indigo Separator (manufacturer Penumbra, Alameda, California 94502 USA) consists of several components of which, the Indigo CAT RX Aspiration Catheter and the INDIGO Separator are indicated for the removal of fresh, soft emboli and thrombi from vessels in the coronary and peripheral vasculature. The device system received the CE mark in November 2021. The primary ...

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Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterised by the dysfunction and degeneration of specialised nerve cells,the motor neurons1. This leads to progressive muscle wasting and weakness affecting mobility,respiration and bulbar function. The worldwide incidence of SMA is approximately 1 in 10,000 live births 2,3. The disease is caused by homozygous deletion and/or mutations of the survival motor neuron 1 (SMN1) gene on chromosome 5,encoding SMN protein. SMN protein is vital for the survival and health of motor ...

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We will offer follow up to children who were found to be at high genetic risk of type 1 diabetes (T1D) in an earlier research study called INGRID. The INGRID study tested for the genetic risk of T1D in newborns. Children at the highest genetic risk were offered entry into trials (POInT, SINT1A) which aimed to delay the onset of T1D. Here, we offer follow up to the children who completed POInT or SINT1A but who have not yet developed ...

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