The Preterm Clinical Network Cohort Research Programme (PCN-CRP) is a series of studies aiming to reduce preterm birth and the problems it can cause. These studies will investigate tests to predict preterm birth, treatments to prevent it, and how to improve outcomes for babies and women’s experience of care. The programme will be carried out in partnership with Tommy’s National Centre for Preterm Birth Research and the UK Preterm Clinical Network (UKPCN). This is a network of ...

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Patients with psoriatic disease have a much higher risk of developing non-alcoholic liver disease. This causes significant impact on their life and is a difficult clinical problem as some therapies for psoriasis and psoriatic arthritis may worsen the liver disease. A new type of MRI scan can measure inflammation and scarring in the liver allowing us to study liver disease in detail. A previous study we led confirmed high rates of liver disease in patients with psoriatic disease but ...

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This observational study is designed to learn more about how current standard of care treatment options are working to treat patients with Systemic Lupus Erythematosus (SLE) and lupus nephritis (LN). SLE is a disease where the body’s immune system mistakenly attacks its own healthy tissues and organs. The study population will include individuals diagnosed with SLE, who have an inadequate response (a lack of response, insufficient response, or lack of sustained response after at least 3-month treatment with appropriate doses of ...

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Injuries to the chest can cause air or blood to collect in the space between the lungs and the ribs. Doctors usually put in a tube to drain it, but we’re not sure if using a smaller tube or a bigger one is better. We will be comparing two treatments: one uses a small tube put in the chest with a needle and wire (called a small bore Seldinger chest drain), and the other uses a large tube put in ...

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Broken bones can happen to anyone, at any age. Sometimes an operation is needed to hold the broken bones together while they heal. One of the complications of this operation is an infection in the area where the bone has been fixed. These are called fracture-related infections (FRI). They can be serious, and usually require more operations. Some surgeons use local antibiotic carriers during the operation to try to lower the risk of FRIs. These are placed directly into the ...

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Angina with Non-Obstructive Coronary Arteries (ANOCA) is a common condition where patients have chest pain despite no major blockages in their heart arteries. ANOCA is caused by problems in the smaller vessels, known as coronary microvascular dysfunction (CMD), or by sudden narrowing of the arteries, called vasospasm. CMD can occur through two main mechanisms: endothelium-dependent mechanisms, where the inner lining of the vessels (the endothelium) doesn’t properly control the widening of the blood vessels or increase in blood flow when ...

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The Registry of Pulmonary Hypertension in Neonates (RePHyNe) is a prospective global multicentre observational cohort data collection study designed to collect routine clinical data including diagnostic tests and treatments delivered as part of patients’ clinical care. Participants will be recruited by clinicians working in neonatal and paediatric intensive care units who routinely provide care for neonates and young infants with pulmonary hypertension < 3 months of age,corrected for prematurity. Written informed consent will be obtained from parents/guardians. Participants will undergo ...

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This study evaluates whether repeat surgical resection at glioblastoma recurrence improves deterioration‑free survival when added to standard second‑line medical therapy. Secondary objectives include assessing the impact of repeat surgery on health‑related quality of life,daily functioning,neurological symptoms,complications,adjuvant therapy completion,overall survival and cost‑effectiveness within the NHS. An optional sub‑study will explore the feasibility of passive physical activity monitoring using smartphones and wearable devices.

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In the United Kingdom each year about 7000 babies are born very preterm and need specialist neonatal care. Necrotising enterocolitis (NEC) is a serious gut condition affecting 1 out of 10 extremely preterm babies (those who are born before 28 completed weeks of pregnancy). Babies with NEC commonly require surgery and, of these, one out of three unfortunately will not survive. About half of NEC survivors have long-term neurodevelopmental problems like cerebral palsy or learning difficulties. Risk factors for NEC ...

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Sometimes, after a first-time shoulder dislocation, surgery is offered to help stop the shoulder from slipping out of place again. This is a common injury in young people, especially those who play sport. During surgery, doctors repair the damaged tissues around the shoulder using keyhole (arthroscopic) techniques, followed by rehabilitation to help regain movement and strength. Others are treated with rehabilitation alone to strengthen the shoulder without surgery. At the moment, there is no clear evidence to show which option ...

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