The main purpose of the trial is to determine when the most beneficial time for people to start or restart a DOAC after their head injury is. People will be asked to start the medication either 1 week or 4 weeks after their head injury. This will be randomly assigned by a computer. They will then be followed closely for 12 weeks and any major bleeding events or a blood clots (thrombotic events) such as a stroke or heart attack ...

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Transcatheter aortic valve implantation (TAVI) is a key-hole technique to replace a faulty (narrowed and/or leaking) aortic heart valve. The replacement aortic valve is delivered to the heart through tubes inserted in a main artery (usually the artery in the groin). Over the past 15 years TAVI has rapidly grown and has taken over from open-heart surgery (surgical aortic valve replacement (SAVR)) to become the most commonly used technique for aortic heart valve replacement. Although TAVI is a safe and effective ...

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CRYSTAL is an observational study whereby participants will attend one 4 ½ -hour visit at the Division of Cardiovascular Medicine,University of Oxford at the John Radcliffe Hospital in Oxford,with the option to split the study visit over two days for convenience. Participants will be recruited from the ALSPAC cohort (G0 mothers cohort),75 will have had a hypertensive pregnancy and 75 will have had a normotensive pregnancy. At time of follow-up,they will be 30-35 years post pregnancy. Of the G0 cohort,2237 ...

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Our aim is to see if palliative long-term abdominal drains (LTADs) result in better quality of life in patients with fluid in the belly due to liver scarring (cirrhosis), compared with current standard of care. The liver can be damaged by excessive alcohol and viral infections. If liver damage continues this scarring leads to permanent damage. It causes a painful buildup of fluid in the abdomen (ascites). Drugs can treat this, but may stop working, leading to ...

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GLO-Surgery is an open label,randomised,international,phase II clinical trial comparing fluorescence guided surgery (FGS) using Indocyanine Green (ICG) and near infra-red fluorescence (NIRF) to surgery using standard white light conditions.

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The overall aim of this study is to elucidate the molecular and cellular mechanisms underlying RSV-induced lung remodelling that contributes to the development of chronic lung disease such as asthma. This can be split into three objectives: 1. Comparison of RSV-induced responses in bronchial ALI cultures derived from asthmatic and non-asthmatic paediatric patients. 2. Determining secreted factors from RSV-infected bronchial ALI cultures that drive fibroblast-myofibroblast differentiation and fibrosis. 3. Transcriptomic analysis and comparison of bronchial cells from RSV-infected patients and bronchial ALI cultures from asthmatic ...

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Three main arrhythmia syndrome phenotypes currently included in the Genomics England (GEL) 100K Genomes Project are: long QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPVT). These disorders are responsible for much of unexplained sudden cardiac death (SCD), an important cause of death in Western countries. A substantial proportion of arrhythmia syndromes are presumed to be due to rare and common genetic variation, however their genetics are variably understood at present and no condition has been ascertained completely. We ...

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We are testing a drug called ginisortamab that blocks a protein called gremlin-1. Gremlin-1 is mainly found outside cancer cells and stops the function of other proteins called bone morphogenetic proteins (BMPs). BMP proteins work by suppressing cancer cells as they occur but in cancer, this mechanism has often been switched off. Blocking gremlin-1 with ginisortamab will allow BMP protein function, and we hope this will change the way the cancer cells develop, making them more sensitive to chemotherapy. We are testing ginisortamab ...

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Research question In patients who have a high-risk primary cutaneous squamous cell carcinoma (HR-cSCC) surgically excised with clear margins,is adjuvant radiotherapy plus close clinical follow-up superior in reducing the risk of loco-regional recurrence compared with close clinical follow-up alone,and if so,is it cost-effective? Background cSCC is the second most common skin cancer in the UK,with annual incidence exceeding 52,000,increasing by 6% p.a (1,2). Treatment,usually surgery,is curative in 95% (3,4). However,5% of patients develop loco-regional recurrence (LRR) which causes 75% of cSCCspecific mortality,substantial morbidity and reduced quality of life (QoL) ...

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The proposed trial tests whether the addition of revumenib,compared to placebo,to azacitidine/venetoclax improves outcome in newly diagnosed adult patients with NPM1-mutated AML,who are not considered candidates for intensive chemotherapy by measuring overall survival. Newly diagnosed,previously untreated patients ≥18 years of age with NPM1-mutated or KMT2A-rearranged AML that are eligible for the study will be randomised in a 1:1 ratio to therapy with azacitidine/venetoclax with revumenib or placebo. Treatment will be on a continuous 28-day cycle schedule and continued until disease progression,development ...

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