Background Psoriasis affects two million people in the UK. People with obesity are more likely to develop psoriasis, have more severe symptoms, and respond less well to treatment. Losing weight can improve psoriasis, and doctors are advised to suggest this, but few do. Our patient collaborators were unaware of the link between psoriasis and carrying excess weight. People with psoriasis believe what they eat is important but often feel that their doctors do not have the answers to their questions. Aim To ...

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Consent for radiotherapy treatment for cancer takes place in emotional circumstances, often focusing on cure or extending life. The impact of treatment on the quality of life after cancer is less regularly discussed. Previous research conducted by the project team revealed that some patients said they didn’t fully understand what their treatment would involve. Some felt unprepared for the impacts on life afterwards. The aim of this study is to improve how people make decisions about consent for radiotherapy ...

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This is a Phase 2, global, multicenter, long-term safety study designed to assess the safety and tolerability of BHV-7000 in participants with focal refractory epilepsy. Approximately 660 eligible subjects will enter this study after completing the DBP of either the BHV7000-302 or BHV7000- 303 studies. In the opinion of the investigator, subjects must have tolerated BHV7000/placebo, during participation in the DBP of the parent studies, BHV7000-302 or BHV7000-303 to be eligible. Eligible subjects who completed the DBP of the BHV7000-302 study will ...

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This study is designed for the patients with coronary artery disease (CAD) who experience severe chest pain (refractory angina) despite taking the best available medications. These patients also have evidence of reversible Ischemia (reduced blood flow), but they are considered high-risk or unsuitable for heart surgery or other currently available medical procedures aimed at restoring blood flow (revascularization procedures). A heart team, including specialists such as cardiologists and surgeons, helps determine their eligibility for the study. Shockwave Medical, Inc. has developed ...

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Prospective cluster randomised cross-over trial We will conduct a prospective cluster randomised cross-over trial (ABAB/BABA) to assess the impact of an AI fracture detection tool in EDs and MIUs in the UK. The trial will involve installing a CE-approved AI algorithm at each site for six months. Sites will be randomly assigned to begin the trial with the AI algorithm either active ("On") or inactive ("Off") during the first month. Thereafter,the algorithm status will alternate each ...

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The 3P project is the foundational study of the TBI-REPORTER Experimental Medicine Network. It will establish the standardisation of protocols for collaborative research within TBI-REPORTER, and demonstrate the feasibility of recruitment and delivery across multiple TBI research centres. The data and samples that emerge in this protocol will allow us to carry out exploratory pilot analyses to allow the rational design of future interventional studies. Thus, the project has the potential to improve current health care and its delivery at ...

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Sepsis is a life-threatening emergency that happens when your body's response to an infection damages vital organs which can often lead to death. In the UK, there are about 245,000 sepsis cases leading to around 48,000 deaths each year, making it a leading cause of death in the UK. Despite considerable recent progress, detecting sepsis in the Emergency Department (ED) remains a challenge. Paramedics and ED doctors often miss signs of sepsis, with the current National Early Warning Score which is ...

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IMPEDE-PKD is a global trial evaluating the long-term efficacy of metformin therapy in slowing the rate of kidney function decline in metformin versus placebo treated Autosomal Dominant Polycystic Kidney Disease (ADPKD) subjects. The UK trial is assessing a primary outcome of change in pain severity from randomisation to 24 months measured using an 11 point numerical rating score (NRS) of average pain over the last 14 days in the ADPKD Pain Assessment Tool (APAT). It is a phase III,international,prospective,multicentre,double-blind,parallel group,placebo-controlled,randomised trial. Secondary ...

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The NHS bowel cancer screening check is offered to everyone over the age of 50. This is a home test kit, called a faecal immunochemical test (FIT). It is used to collect a small sample of stool (poo) which is sent to a lab to be checked for tiny amounts of blood. Your GP may also order a FIT if you have had a change in bowel habits or are experiencing abdominal (tummy) pain. In this study we will be ...

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Already existing and coded tumor biological material from the lymph node biopsy and personal health-related data of patients who have been diagnosed with NMZL will be collected retrospectively.The value of the expected results of the IELSG52 study are: (i) to inform on diagnosis and prognosis of NMZL; (ii) to allow selection of optimal therapy; and (iii) to provide a biology based framework on which to design and interpret clinical trials

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