A pleural effusion is a build-up of fluid around the lung. In the UK, about 250,000 people develop a pleural effusion each year. People with a pleural effusion feel breathless and can’t do the things they want to. Draining the fluid helps with this, reducing breathlessness and improving quality of life. This can be done by inserting a semi-permanent tube called an indwelling pleural catheter (IPC). This is drained at home several times a week, usually by a community nurse. ...

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The aim of this study is to develop a reliable, validated, multidimensional questionnaire to assess breakthrough pain in 3-months-25-year-olds. Two versions of the questionnaire will be developed: a self-report form and a form for caregivers/healthcare professionals (for pre- or non-verbal children). This is a mixed-methods study comprising three separate studies. We will develop a first draft (alpha) version of the paediatric BTP questionnaire using standard, approved methodology. In the first study (Study 1), we will carry out interviews with children and ...

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This is a global open-label, randomized, multicenter, interventional study in pregnant participants with a prior FNAIT-affected pregnancy to assess the efficacy, safety, tolerability, PK, PD, and immunogenicity of nipocalimab or IVIG. ‘IVIG’ throughout the protocol will be referring to the IVIG with or without prednisone regimen adapted from Bussel et al (Bussel 2021). The studywill target participants whose current pregnancies are affected by HPA-1a and/or HPA-5b incompatibility. Maternal participants with alloantibodies against both HPA-1a and HPA-5b will be categorized under HPA-1a ...

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Kidney transplantation is the optimal treatment for chronic kidney failure, offering extended life and freedom from dialysis. However, in 2019/20, of the 8,300 UK patients on the transplant list, only 3,400 received a kidney, while 3,300 were suspended, and 400 died waiting. To address the organ shortage, more kidneys from higher-risk donors, such as those donated after circulatory death (DCD) or from older/sicker individuals, are being used. These kidneys are at greater risk of poor long-term function, often requiring recipients ...

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Bone conduction devices (BCD's) are hearing aids which are given to people with a mixed or conductive hearing loss to improve their hearing. These devices deliver sounds to the patient by sending vibrations through the skull to stimulate the hearing organ. This study is looking to see if patients with a smaller degree of mixed or conductive hearing loss than would normally be considered for a BCD also so benefit from a BCD when we compare their speech understanding with ...

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Title: Cryopreservation of prepubertal testicular tissue for preservation of fertility in young boys with cancer Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys. With informed consent, we aim to cryopreserve (freeze) testis tissue biopsies taken from boys undergoing cancer therapy with a high risk of infertility. A portion of cryopreserved tissue will be securely stored which in the future may be used to ...

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(Diffuse) large B-cell lymphoma (D)LBCL is a cancer of the lymphatic system. Approximately 5,500 people are diagnosed with LBCL per year in the United Kingdom (UK), representing approximately 30-40% of people diagnosed with non-Hodgkin lymphoma (NHL). The usual treatment for patients newly diagnosed with LBCL is a combination of anti-cancer drugs called R-CHOP which are given for approximately 6 months. In practice, around half the patients diagnosed with LBCL are unsuitable for ‘full-dose’ and standard of care R-CHOP or Pola-R-CHP ...

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Each year in the UK, around 37,000 patients have radiotherapy for breast cancer. Radiotherapy uses radiation to kill cancer cells. Radiotherapy is given to the breast and, if needed, to the lymph node regions in daily doses. Until recently most patients needed at least 15 daily treatments of radiotherapy. In addition, around 10,000 women per year in the UK needed up to 8 extra radiation treatments to the part of the breast where the cancer was, resulting in a total ...

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The relationship between cabergoline treatment of prolactinoma,the most frequently occurring secretory pituitary tumour and psychiatric side effects remains unclear. Understanding the frequency with which these side effects occur,particularly impulse control disorders and the risk factors for their development is important for healthcare professionals to counsel and monitor patients. This is a prospective study using questionnaires at specific timepoints to investigate psychiatric side effects of cabergoline in patients receiving this for the management of prolactinomas. STUDY OBJECTIVES Primary objective To investigate the ...

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Children and young people (CYP) with problems with sore joints called Juvenile idiopathic Arthritis (JIA) or problems with their immune system (rheumatological issues) have a range of complaints, such as painful, stiff joints. These problems come and go and can stop CYP attending school. In adulthood, symptoms may affect what job they are able to do. CYP often need to take medications with severe side effects. CYP are usually watched closely to ensure that their medications are working and side ...

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