Prospective cluster randomised cross-over trial We will conduct a prospective cluster randomised cross-over trial (ABAB/BABA) to assess the impact of an AI fracture detection tool in EDs and MIUs in the UK. The trial will involve installing a CE-approved AI algorithm at each site for six months. Sites will be randomly assigned to begin the trial with the AI algorithm either active ("On") or inactive ("Off") during the first month. Thereafter,the algorithm status will alternate each ...

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The 3P project is the foundational study of the TBI-REPORTER Experimental Medicine Network. It will establish the standardisation of protocols for collaborative research within TBI-REPORTER, and demonstrate the feasibility of recruitment and delivery across multiple TBI research centres. The data and samples that emerge in this protocol will allow us to carry out exploratory pilot analyses to allow the rational design of future interventional studies. Thus, the project has the potential to improve current health care and its delivery at ...

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Sepsis is a life-threatening emergency that happens when your body's response to an infection damages vital organs which can often lead to death. In the UK, there are about 245,000 sepsis cases leading to around 48,000 deaths each year, making it a leading cause of death in the UK. Despite considerable recent progress, detecting sepsis in the Emergency Department (ED) remains a challenge. Paramedics and ED doctors often miss signs of sepsis, with the current National Early Warning Score which is ...

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IMPEDE-PKD is a global trial evaluating the long-term efficacy of metformin therapy in slowing the rate of kidney function decline in metformin versus placebo treated Autosomal Dominant Polycystic Kidney Disease (ADPKD) subjects. The UK trial is assessing a primary outcome of change in pain severity from randomisation to 24 months measured using an 11 point numerical rating score (NRS) of average pain over the last 14 days in the ADPKD Pain Assessment Tool (APAT). It is a phase III,international,prospective,multicentre,double-blind,parallel group,placebo-controlled,randomised trial. Secondary ...

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The NHS bowel cancer screening check is offered to everyone over the age of 50. This is a home test kit, called a faecal immunochemical test (FIT). It is used to collect a small sample of stool (poo) which is sent to a lab to be checked for tiny amounts of blood. Your GP may also order a FIT if you have had a change in bowel habits or are experiencing abdominal (tummy) pain. In this study we will be ...

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The study sponsor UCB is developing doxecitine and doxribtimine as a treatment for patients with the condition thymidine kinase 2 deficiency (TK2d) with an age of symptom onset on or below 12 years of age. In the majority of prior research, untreated TK2d patients have been used as the 'control group' in the survival analysis, versus patients treated with doxecitine and doxribtimine. The purpose of this study is to identify the untreated patients and review their medical records to perform Source Data ...

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Already existing and coded tumor biological material from the lymph node biopsy and personal health-related data of patients who have been diagnosed with NMZL will be collected retrospectively.The value of the expected results of the IELSG52 study are: (i) to inform on diagnosis and prognosis of NMZL; (ii) to allow selection of optimal therapy; and (iii) to provide a biology based framework on which to design and interpret clinical trials

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Hypothesis: Selected treatments that target key neurodegenerative / neuroprotective pathways in PD will slow disease progression compared to placebo. Aims: • To assess the clinical and cost-effectiveness of at least 3 potential disease modifying therapies (DMTs) compared with a shared placebo on the rate of progression of Parkinson's Disease (PD). • To establish sustainable infrastructure for the long-term evaluation of clinical and cost effectiveness of further potential DMTs in PD. • To recruit a representative study population. Methods: • We will recruit 1200 participants from 40 UK sites over ...

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This is a protocol to support primary research into the condition-specific needs of young adults in the UK who store ovarian or testicular tissue after childhood cancer, their parents and the healthcare professionals who provide reproductive survivorship care. This research will be used to help inform the development of a care support tool to help clinical teams look after young adults who store tissue after childhood cancer, and to support their parents/guardians. The tool will be developed and tested in ...

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Every day in the UK, 10 people over 65 years develop kidney failure. More of these older adults are receiving kidney transplants. People with transplants need to take tablets to prevent their bodies from rejecting the transplant(‘immunosuppression’). The immune system becomes less effective in later life, meaning lower doses of immunosuppression tablets may be enough to stop transplant rejection. The amount of immunosuppression medication given to older transplant recipients is currently based on research in young people. Immunosuppression tablets affect older ...

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