This is a multi-centre,first-in-human Phase I/IIa dose escalation and dose expansion trial in participants with haematological malignancies. NVG-222 is an autoregulating,half-life extended bispecific ROR1-directed TCE. NVG- 222 will be the first agent to be tested in the clinic that includes an AR mechanism based on granzyme B cleavage. The addition of an IgG1 Fc domain to NVG-222 provides for an extended half-life,allowing a more convenient Q2W dosing regimen compared with continuous IV infusions required for a previous agent NVG-111. The ...

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This application is for a health economics analysis alongside the ongoing WHEAT Trial (IRAS 309894). Babies born prematurely are at risk of necrotising enterocolitis (NEC), a serious gut disease that causes over 200 deaths yearly in the UK – about 1 in 20 of all child deaths. Babies who survive NEC often face long-term gut and brain damage. Premature babies are fed milk every few hours and often need blood transfusions for anaemia (low red blood cells). Some doctors worry that ...

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PIVOTAL is a multi-centre, randomised, Bayesian adaptive platform trial in paediatric intensive care which aims to evaluate multiple important research questions at the same time, with an integrated economic evaluation, internal pilot phase, and patient follow-up at 6 months. The primary platform clinical objective is to investigate the effects of a range of intervention(s) on the ordinal outcome of death or days alive and free from organ support to day 30. The primary platform health economic objective is to investigate the ...

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Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Our work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain ...

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Our aim is to generate the evidence base for improving the care received and patient/family experience for teenagers transitioning from paediatric to adult ICU services. A growing number of children admitted to paediatric intensive care units (ICUs) with chronic conditions and complex needs are later admitted to adult ICUs that often do not know them and are unprepared, compromising care and patient experience at a time of heightened vulnerability. Recent guidelines by the UK Paediatric Critical Care Society (PCCS) and Intensive Care ...

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This study is a cross-sectional, multi-country, observational study involving Adolescent and Adult Patients with Alopecia Areata (AA), Vitiligo, or Hidradenitis Suppurativa (HS) in real-world clinical practice. Both patient-reported and physician-reported outcomes will be documented. Alopecia areata (AA) is a condition that causes patchy hair loss, typically on the scalp, but can also affect other areas such as the eyebrows, beard, or body hair. It’s an autoimmune condition where the immune system mistakenly attacks the hair follicles, leading to sudden hair ...

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KRIYA-825-901(OBSERVE) is an observational study of participants with Geographic Atrophy (GA), which is an advance form of age-related macular degeneration. This is a 2-part study run in parallel to the First in Human KRIYA-825-101(VISION) open label study, designed to test how safe, tolerable and effective a gene therapy (VV-14295) is at treating GA. In part 1 of this study investigators review potential participants’ medical charts and retrospective eye examination records since 2022 to determine if they are eligible for the KRIYA-825-101 study. ...

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Aortic regurgitation (AR) occurs in approximately 0.4% of all adults, in 1% of individuals aged 65-74 years and 2% of individuals over 70 years of age. Symptomatic patients with chronic severe AR have a poor prognosis and should therefore undergo surgical aortic valve replacement (SAVR) per current guidelines. SAVR is an open-heart surgery that necessitates the use of cardiopulmonary bypass as well as cardiac arrest. This extensive intervention, performed under general anesthesia, can jeopardize vital organ functions, particularly in older patients, potentially ...

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Background Psoriasis affects two million people in the UK. People with obesity are more likely to develop psoriasis, have more severe symptoms, and respond less well to treatment. Losing weight can improve psoriasis, and doctors are advised to suggest this, but few do. Our patient collaborators were unaware of the link between psoriasis and carrying excess weight. People with psoriasis believe what they eat is important but often feel that their doctors do not have the answers to their questions. Aim To ...

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Consent for radiotherapy treatment for cancer takes place in emotional circumstances, often focusing on cure or extending life. The impact of treatment on the quality of life after cancer is less regularly discussed. Previous research conducted by the project team revealed that some patients said they didn’t fully understand what their treatment would involve. Some felt unprepared for the impacts on life afterwards. The aim of this study is to improve how people make decisions about consent for radiotherapy ...

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