This is a post-authorisation study evaluating the effectiveness and safety of belzutifan in routine clinical practice. It will include Adult (> = 18 years of age) patients with von Hippel-Lindau (VHL) disease for which a decision has been made by the treating physician to initiate belzutifan treatment. The study aims to enroll up to 100 patients with VHL disease-associated renal cell carcinoma (RCC) and/or central nervous system (CNS) hemangioblastoma. This includes approximately 40 patients with VHL disease-associated RCC and approximately ...

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This cognitive function decline study comparing haemodialysis (HD) patients with peritoneal dialysis (PD) patients will be conducted using the DOPPS and PDOPPS (Peritoneal Dialysis Outcomes and Practice Patterns Study) core protocols and infrastructures in the UK. This will allow comparison of change of cognitive function in incident HD and PD patients over time, with the hypothesis that PD is associated with less cognitive impairment (CI) and slower progression of CI than HD.

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This application is for a health economics analysis alongside the ongoing WHEAT Trial (IRAS 309894). Babies born prematurely are at risk of necrotising enterocolitis (NEC), a serious gut disease that causes over 200 deaths yearly in the UK – about 1 in 20 of all child deaths. Babies who survive NEC often face long-term gut and brain damage. Premature babies are fed milk every few hours and often need blood transfusions for anaemia (low red blood cells). Some doctors worry that ...

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Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Our work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain ...

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This study is a cross-sectional, multi-country, observational study involving Adolescent and Adult Patients with Alopecia Areata (AA), Vitiligo, or Hidradenitis Suppurativa (HS) in real-world clinical practice. Both patient-reported and physician-reported outcomes will be documented. Alopecia areata (AA) is a condition that causes patchy hair loss, typically on the scalp, but can also affect other areas such as the eyebrows, beard, or body hair. It’s an autoimmune condition where the immune system mistakenly attacks the hair follicles, leading to sudden hair ...

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KRIYA-825-901(OBSERVE) is an observational study of participants with Geographic Atrophy (GA), which is an advance form of age-related macular degeneration. This is a 2-part study run in parallel to the First in Human KRIYA-825-101(VISION) open label study, designed to test how safe, tolerable and effective a gene therapy (VV-14295) is at treating GA. In part 1 of this study investigators review potential participants’ medical charts and retrospective eye examination records since 2022 to determine if they are eligible for the KRIYA-825-101 study. ...

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Background Psoriasis affects two million people in the UK. People with obesity are more likely to develop psoriasis, have more severe symptoms, and respond less well to treatment. Losing weight can improve psoriasis, and doctors are advised to suggest this, but few do. Our patient collaborators were unaware of the link between psoriasis and carrying excess weight. People with psoriasis believe what they eat is important but often feel that their doctors do not have the answers to their questions. Aim To ...

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Consent for radiotherapy treatment for cancer takes place in emotional circumstances, often focusing on cure or extending life. The impact of treatment on the quality of life after cancer is less regularly discussed. Previous research conducted by the project team revealed that some patients said they didn’t fully understand what their treatment would involve. Some felt unprepared for the impacts on life afterwards. The aim of this study is to improve how people make decisions about consent for radiotherapy ...

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This is a Phase 2, global, multicenter, long-term safety study designed to assess the safety and tolerability of BHV-7000 in participants with focal refractory epilepsy. Approximately 660 eligible subjects will enter this study after completing the DBP of either the BHV7000-302 or BHV7000- 303 studies. In the opinion of the investigator, subjects must have tolerated BHV7000/placebo, during participation in the DBP of the parent studies, BHV7000-302 or BHV7000-303 to be eligible. Eligible subjects who completed the DBP of the BHV7000-302 study will ...

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This study is designed for the patients with coronary artery disease (CAD) who experience severe chest pain (refractory angina) despite taking the best available medications. These patients also have evidence of reversible Ischemia (reduced blood flow), but they are considered high-risk or unsuitable for heart surgery or other currently available medical procedures aimed at restoring blood flow (revascularization procedures). A heart team, including specialists such as cardiologists and surgeons, helps determine their eligibility for the study. Shockwave Medical, Inc. has developed ...

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