Why is the study being done? We want to find out if a blood test that detects circulating microRNA (miRNA) could be used to detect if a patient’s cancer has returned. Testicular seminoma is one of the commonest cancers in young men; ovarian dysgerminoma is rarer, typically affecting teenagers/young adults. Stage I disease is well managed with surgery followed by surveillance using imaging (CT or MRI, or ultrasound for younger dysgerminoma patients) but this is a burden for patients, may expose them ...

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We will aim to see whether a device that helps with breathing exercises can improve recovery for older people when taken to hospital with broken ribs. Broken ribs are painful and can make it harder to take a deep breath or cough. Over half of older people with broken ribs then develop problems, like chest infections. We think that a device called an ‘incentive spirometer’ (IS) which helps people take a deeper breath, may help to prevent these problems. These ...

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Intellectual disability (ID) affects a person’s ability to learn, reason, and manage daily tasks; ID is common in people with Dravet syndrome (DS), Lennox-Gastaut syndrome (LGS) and tuberous sclerosis complex (TSC), which are forms of epilepsy. Challenging behaviour refers to actions that are extreme or difficult to manage, potentially putting the person or others at risk and making it difficult to take part in everyday activities. People with ID and epilepsy are more likely to show challenging behaviours. These behavioural ...

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This trial will determine future guideline recommendations for patients with bronchiectasis. P. aeruginosa is difficult to treat and patients are at high risk of hospitalization, lung function decline and death (4,5) Preventing long term P. aeruginosa infection is therefore highly desirable. The NHS spends more than £30m annually on managing bronchiectasis (8). A US study comparing healthcare costs before and after acquisition of P. aeruginosa reported an 87% increase from $36,213 to $67,764 annually per patient (10,11). Determining the efficacy ...

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Each year, many babies are born prematurely (before 37 weeks of pregnancy). Babies born early are at higher risk of later difficulties, particularly with language development. During pregnancy, babies begin to hear sounds from around 25 weeks. Inside the womb, sounds are naturally softened and filtered by the mother’s body. This means that babies mainly hear the rhythm and melody of speech, rather than clear individual words or sounds. Hearing these speech patterns before birth helps prepare babies’ brains for learning ...

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The Preterm Clinical Network Cohort Research Programme (PCN-CRP) is a series of studies aiming to reduce preterm birth and the problems it can cause. These studies will investigate tests to predict preterm birth, treatments to prevent it, and how to improve outcomes for babies and women’s experience of care. The programme will be carried out in partnership with Tommy’s National Centre for Preterm Birth Research and the UK Preterm Clinical Network (UKPCN). This is a network of ...

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Patients with psoriatic disease have a much higher risk of developing non-alcoholic liver disease. This causes significant impact on their life and is a difficult clinical problem as some therapies for psoriasis and psoriatic arthritis may worsen the liver disease. A new type of MRI scan can measure inflammation and scarring in the liver allowing us to study liver disease in detail. A previous study we led confirmed high rates of liver disease in patients with psoriatic disease but ...

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This observational study is designed to learn more about how current standard of care treatment options are working to treat patients with Systemic Lupus Erythematosus (SLE) and lupus nephritis (LN). SLE is a disease where the body’s immune system mistakenly attacks its own healthy tissues and organs. The study population will include individuals diagnosed with SLE, who have an inadequate response (a lack of response, insufficient response, or lack of sustained response after at least 3-month treatment with appropriate doses of ...

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Injuries to the chest can cause air or blood to collect in the space between the lungs and the ribs. Doctors usually put in a tube to drain it, but we’re not sure if using a smaller tube or a bigger one is better. We will be comparing two treatments: one uses a small tube put in the chest with a needle and wire (called a small bore Seldinger chest drain), and the other uses a large tube put in ...

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Angina with Non-Obstructive Coronary Arteries (ANOCA) is a common condition where patients have chest pain despite no major blockages in their heart arteries. ANOCA is caused by problems in the smaller vessels, known as coronary microvascular dysfunction (CMD), or by sudden narrowing of the arteries, called vasospasm. CMD can occur through two main mechanisms: endothelium-dependent mechanisms, where the inner lining of the vessels (the endothelium) doesn’t properly control the widening of the blood vessels or increase in blood flow when ...

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