Consent for radiotherapy treatment for cancer takes place in emotional circumstances, often focusing on cure or extending life. The impact of treatment on the quality of life after cancer is less regularly discussed. Previous research conducted by the project team revealed that some patients said they didn’t fully understand what their treatment would involve. Some felt unprepared for the impacts on life afterwards. The aim of this study is to improve how people make decisions about consent for radiotherapy ...

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Sepsis is a life-threatening emergency that happens when your body's response to an infection damages vital organs which can often lead to death. In the UK, there are about 245,000 sepsis cases leading to around 48,000 deaths each year, making it a leading cause of death in the UK. Despite considerable recent progress, detecting sepsis in the Emergency Department (ED) remains a challenge. Paramedics and ED doctors often miss signs of sepsis, with the current National Early Warning Score which is ...

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Already existing and coded tumor biological material from the lymph node biopsy and personal health-related data of patients who have been diagnosed with NMZL will be collected retrospectively.The value of the expected results of the IELSG52 study are: (i) to inform on diagnosis and prognosis of NMZL; (ii) to allow selection of optimal therapy; and (iii) to provide a biology based framework on which to design and interpret clinical trials

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The Anterior Cruciate Ligament (ACL) is an important band of tissue that supports the knee. It is a strong structure in the centre of the knee which attaches the femur (thigh bone) to the tibia (shin bone). It is often injured during sport. Injury to the ACL can lead to the knee becoming unstable and giving way. An unstable knee can cause damage to other parts of the knee like the cartilage or meniscus (shock absorbers), which can lead to ...

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The overarching aim of the RAISE project is to provide self-management and psychological support for people with rare autoimmune rheumatic diseases; these include systemic lupus erythematosus, vasculitis, scleroderma, myositis and Sjogren’s syndrome. These diseases can affect people of any age and have a negative impact on peoples’ quality of life (social, work and family life). More than 80% of NHS Rheumatology departments do not provide any support to help patients deal with the impact of living with one of these ...

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The retina is the layer at the back of the eye that gives sight. Normally it is attached to the wall of the eye, but can separate in a condition called rhegmatogenous retinal detachment(RRD). RRD causes sight loss and requires surgery. The most common surgery to treat a RRD is Vitrectomy however, Vitrectomy can have complications. The most common is cataracts which get worse with time. When they affect vision they need to be removed with surgery. In cataract surgery the foggy lens is changed ...

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Exercising regularly and is an essential part of managing Type 1 Diabetes, as it improves blood sugar control, reduces insulin requirements and risk of complications of diabetes and also improves cardiovascular and mental health. Despite this, very few people with type 1 diabetes exercise regularly and thus do not get these benefits. Managing glucose levels within safe ranges when exercising remains challenging, particularly for children. Fear of having hypoglycaemic episode (where glucose levels drop dangerously low) is a key barrier ...

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Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded cytosine-adenine-guanine (CAG) repeat in exon 1 on chromosome 4 of the huntingtin gene (HTT). This results in the production of a mutant huntingtin protein with an abnormally long CAG repeat leading to multiple downstream pathogenic effects and selective neuropathology. Those with greater than 39 CAG repeats are certain to develop the disease, while reduced penetrance is seen between 36 and 39 CAG repeats. Most individuals with HD ...

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This is a study putting together large numbers of patients with menopause and other menopause-related conditions to better understand the patient journey. The purpose is to answer questions about the diagnosis and management of menopause, which will be best assessed by combining these cases at a national level with patients recruited from centres throughout UK and Ireland. The information will be confidential and stored in a secure platform. Patients will be approached for consent to gather their data by their ...

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This observational cohort study will mainly use routinely collected data,e.g.,medical history,available laboratory blood/urine results,patient-reported health data,and documented treatment errors/complications of scheduled routine consultations and planned or emergency hospitalisations,with two data collection methods (Figure 1):  First,a retrospective & cross-sectional assessment of variables of interest from the time of study inclusion back to the time of onset and diagnosis of the condition.  Second,a prospective design assessing variables of interest from the time of inclusion up to five years of follow-up. Patients with an ...

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