This retrospective observational chart review study aims to analyse the standard of care for patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) treated with immunoglobulin (Ig) therapy. The review will examine treatment patterns, clinical outcomes, and disease progression. Data will be gathered from existing patient records, including demographic characteristics, treatment regimes, and clinical assessments over time. There are no study-specific interventional procedures required of the principal investigator (PI) or patient to meet the needs of the study objectives. Additionally, there are ...

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This application is for a health economics analysis alongside the ongoing WHEAT Trial (IRAS 309894). Babies born prematurely are at risk of necrotising enterocolitis (NEC), a serious gut disease that causes over 200 deaths yearly in the UK – about 1 in 20 of all child deaths. Babies who survive NEC often face long-term gut and brain damage. Premature babies are fed milk every few hours and often need blood transfusions for anaemia (low red blood cells). Some doctors worry that ...

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Consent for radiotherapy treatment for cancer takes place in emotional circumstances, often focusing on cure or extending life. The impact of treatment on the quality of life after cancer is less regularly discussed. Previous research conducted by the project team revealed that some patients said they didn’t fully understand what their treatment would involve. Some felt unprepared for the impacts on life afterwards. The aim of this study is to improve how people make decisions about consent for radiotherapy ...

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This study is designed for the patients with coronary artery disease (CAD) who experience severe chest pain (refractory angina) despite taking the best available medications. These patients also have evidence of reversible Ischemia (reduced blood flow), but they are considered high-risk or unsuitable for heart surgery or other currently available medical procedures aimed at restoring blood flow (revascularization procedures). A heart team, including specialists such as cardiologists and surgeons, helps determine their eligibility for the study. Shockwave Medical, Inc. has developed ...

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Prospective cluster randomised cross-over trial We will conduct a prospective cluster randomised cross-over trial (ABAB/BABA) to assess the impact of an AI fracture detection tool in EDs and MIUs in the UK. The trial will involve installing a CE-approved AI algorithm at each site for six months. Sites will be randomly assigned to begin the trial with the AI algorithm either active ("On") or inactive ("Off") during the first month. Thereafter,the algorithm status will alternate each ...

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Sepsis is a life-threatening emergency that happens when your body's response to an infection damages vital organs which can often lead to death. In the UK, there are about 245,000 sepsis cases leading to around 48,000 deaths each year, making it a leading cause of death in the UK. Despite considerable recent progress, detecting sepsis in the Emergency Department (ED) remains a challenge. Paramedics and ED doctors often miss signs of sepsis, with the current National Early Warning Score which is ...

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The study sponsor UCB is developing doxecitine and doxribtimine as a treatment for patients with the condition thymidine kinase 2 deficiency (TK2d) with an age of symptom onset on or below 12 years of age. In the majority of prior research, untreated TK2d patients have been used as the 'control group' in the survival analysis, versus patients treated with doxecitine and doxribtimine. The purpose of this study is to identify the untreated patients and review their medical records to perform Source Data ...

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Already existing and coded tumor biological material from the lymph node biopsy and personal health-related data of patients who have been diagnosed with NMZL will be collected retrospectively.The value of the expected results of the IELSG52 study are: (i) to inform on diagnosis and prognosis of NMZL; (ii) to allow selection of optimal therapy; and (iii) to provide a biology based framework on which to design and interpret clinical trials

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The Anterior Cruciate Ligament (ACL) is an important band of tissue that supports the knee. It is a strong structure in the centre of the knee which attaches the femur (thigh bone) to the tibia (shin bone). It is often injured during sport. Injury to the ACL can lead to the knee becoming unstable and giving way. An unstable knee can cause damage to other parts of the knee like the cartilage or meniscus (shock absorbers), which can lead to ...

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The overarching aim of the RAISE project is to provide self-management and psychological support for people with rare autoimmune rheumatic diseases; these include systemic lupus erythematosus, vasculitis, scleroderma, myositis and Sjogren’s syndrome. These diseases can affect people of any age and have a negative impact on peoples’ quality of life (social, work and family life). More than 80% of NHS Rheumatology departments do not provide any support to help patients deal with the impact of living with one of these ...

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