The expansion of advanced therapies that target disease-specific pathways has changed the way patients with psoriatic arthritis (PsA) are treated. However, despite the effectiveness of these therapies many patients do not achieve optimal response. Women are less likely to achieve remission, are prone to develop adverse effects and tend to discontinue treatments earlier than men. This prospective, multicenter, international cohort study recruiting 540 patients from diverse populations aims to understand how sex and gender, and their intersection with age and ...

GO TO STUDY

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study of pegozafermin for the treatment of Stage 2 or 3 liver fibrosis in adult subjects with NASH (Noncirrhotic Nonalcoholic Steatohepatitis). The study is designed to assess the efficacy and safety of 2 dose regimens of pegozafermin, administered either weekly (QW) or once every 2 weeks (Q2W) in subjects with biopsy-confirmed NASH (NAFLD activity score [NAS] ≥ 4, fibrosis stage F2 or F3 [NASH CRN system]). Approximately 840 subjects will be randomized 1:1:1 ...

GO TO STUDY

This is a multi-national, randomized, double-blinded study to evaluate the safety and effectiveness of AVIM therapy in patients with uncontrolled hypertension with a previously implanted Medtronic Astra/Azure pacemaker. Over 500 participants will be recruited across 100 sites in UK, Europe and US. AVIM is an investigational therapy that can be added to a pacemaker to allow for specific settings that may help with the treatment of hypertension. The study will be performed in three phases, Screening/Run-In, Randomised double-blind and Randomised ...

GO TO STUDY

Terumo Aortic is a global medical device company dedicated to developing solutions for aortic and peripheral vascular disease. The purpose of this study is to gather further information on the use of the Thoraflex Hybrid device alone and in combination with the RelayPro NBS Stent-graft; to treat aortic disease affecting the aortic arch and descending aorta with or without involvement of the ascending aorta. Both devices received CE certification, demonstrating conformity to applicable EU requirements. The Thoraflex Hybrid is ...

GO TO STUDY

Living with chronic pain can be tough for any young person. But while some young people may experience distressing thoughts, others may not. No young person should face these problems alone. So, it’s important for us to figure out who might be more vulnerable to distress, when, and why. That way, we can be there for them when they need it most. In total, 70 young people with chronic pain (aged 12-19 years) will be invited to take part. Over a ...

GO TO STUDY

This is a prospective, observational, non-interventional, multi-center, global clinical study of subjects with early to advanced stage STGD1 caused by bi-allelic likely pathogenic or pathogenic variants in the ABCA4 gene, confirmed genotypically by an accredited genotyping laboratory. The study will consist of 6 visits over a 96-week study period: Visit 1 (Screening Visit), Visit 2 (Week 16), Visit 3 (Week 32) Visit 4 (Week 48), Visit 5 (Week 72), and Visit 6 (Week 96). Subjects who discontinue the study early will ...

GO TO STUDY

Atrial Fibrillation (AF) is the most common cardiac arrhythmia and carries an increased risk of stroke. Stroke risk is commonly assessed using the CHA2DS2-VASC scoring system. To reduce stroke risk, guidelines advise AF patients with higher CHA2DS2-VASC scores be treated with oral anticoagulation (OAC), also known as blood thinning medication. OAC reduces the stroke risk, however it also increases the risk of bleeding episodes, which can be major and life-threatening. AF patterns can vary between patients. One patient may have only one ...

GO TO STUDY

Broken ankles in children often involve the area from which the bone grows – the growth plate. Following growth plate injuries, the growth of the main shin bone in the lower leg (the tibia) can be altered permanently, which can cause the bone to not grow at all, or to grow wonky. The younger the child at the time of injury (i.e. the more they have to grow) the worse the problem may get once the child has fully grown. ...

GO TO STUDY

Survivors of childhood cancer experience impaired health-related quality of life, psychological distress, and pain. A previously developed body mindset intervention has improved health-related quality of life and symptom distress in adult cancer patients. In the current research, we will examine whether a body mindset intervention can instil adaptive body mindsets, boost resilience, and improve physical and psychological functioning in survivors of childhood cancer. Survivors of childhood cancer will be randomised to the body mindset intervention or an active attention control group. ...

GO TO STUDY

Perianal fistula in Crohn's Disease (CD-pAF) is an abnormal tunnel that develops between the end of the bowel and the skin near the anus. It affects one third of Crohn's Disease (CD) patients causing significant morbidity and poor quality of life. Patients with CD-pAF are treated with several combined approaches involving medical and various surgical techniques with high failure rates (around 50%). The study will provide an evidence base to identify predictors of fistula healing, potentially modifiable factors, ...

GO TO STUDY