Myeloma (MM) is an incurable blood cancer. While survival has substantially improved over the last decade, there is still huge variability in clinical outcomes between patients. The current approach to drug development assumes that all patients respond similarly to a given drug despite the fact that only a third of MM patients are eligible to take part in therapeutic clinical trials. Within the NHS, the current treatment approach to MM means that all patients receive the same treatments according ...

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The main purpose of the trial is to determine when the most beneficial time for people to start or restart a DOAC after their head injury is. People will be asked to start the medication either 1 week or 4 weeks after their head injury. This will be randomly assigned by a computer. They will then be followed closely for 12 weeks and any major bleeding events or a blood clots (thrombotic events) such as a stroke or heart attack ...

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This is a Phase 2a, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability, and safety of frexalimab, SAR442970, and rilzabrutinib in participants from 16 to 75 years of age with biopsy-proven primary FSGS or MCD, with eGFR ≥ 45 mL/min/1.73 m2, and UPCR ≥ 3 g/g at screening, who have demonstrated at least partial response (≥ 40% UPCR reduction) to at least one previous immunosuppressive therapy. The purpose of this study is to measure the change in proteinuria and its impact ...

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Transcatheter aortic valve implantation (TAVI) is a key-hole technique to replace a faulty (narrowed and/or leaking) aortic heart valve. The replacement aortic valve is delivered to the heart through tubes inserted in a main artery (usually the artery in the groin). Over the past 15 years TAVI has rapidly grown and has taken over from open-heart surgery (surgical aortic valve replacement (SAVR)) to become the most commonly used technique for aortic heart valve replacement. Although TAVI is a safe and effective ...

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Background Sciatica is a term used to describe pain in the leg, but it is actually caused by an irritation of the small nerves in the lower back. One in four people with sciatica also report weakness in the affected leg. In my recent work, 85% of people coming to a hospital appointment for sciatica reported leg weakness, but our hospital tests detected weakness in only 34% of them. This means that many people have a problem that their health ...

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This study will test if a new software program called EpiPredict can predict which biologic therapy might work best for treating Crohn’s disease (CD). This study will include about 378 participants from 6 countries in Europe, and about 98 participants in the United Kingdom (UK). EpiPredict will predict how well two biologics for CD (vedolizumab and ustekinumab) will work. Both vedolizumab and ustekinumab are approved for use in people with CD as part of their usual care. This study is testing if ...

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CRYSTAL is an observational study whereby participants will attend one 4 ½ -hour visit at the Division of Cardiovascular Medicine,University of Oxford at the John Radcliffe Hospital in Oxford,with the option to split the study visit over two days for convenience. Participants will be recruited from the ALSPAC cohort (G0 mothers cohort),75 will have had a hypertensive pregnancy and 75 will have had a normotensive pregnancy. At time of follow-up,they will be 30-35 years post pregnancy. Of the G0 cohort,2237 ...

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Our aim is to see if palliative long-term abdominal drains (LTADs) result in better quality of life in patients with fluid in the belly due to liver scarring (cirrhosis), compared with current standard of care. The liver can be damaged by excessive alcohol and viral infections. If liver damage continues this scarring leads to permanent damage. It causes a painful buildup of fluid in the abdomen (ascites). Drugs can treat this, but may stop working, leading to ...

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GLO-Surgery is an open label,randomised,international,phase II clinical trial comparing fluorescence guided surgery (FGS) using Indocyanine Green (ICG) and near infra-red fluorescence (NIRF) to surgery using standard white light conditions.

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In a recently completed clinical trial funded by the NIHR, evaluating the effects of gene therapy in patients with early stage choroideremia, subsequent analysis the patients with a 'smooth zone' of central retinal autofluorescence indicated that the degeneration might been slowed. It appears that as the disease progresses, the smooth zone becomes mottled and then disappears completely with vision loss. We therefore believe that smooth zone analysis will be very helpful in a follow-on clinical trial. Before doing this, however, ...

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