Basal thumb osteoarthritis (BTOA) is a common condition that affects 21% of the population by the age of 40 and 45% by the age of 80. BTOA causes significant problems in this large population with symptoms including pain, tenderness and stiffness. There are a variety of non-surgical and surgical treatments available for BTOA. If non-surgical treatment fails then surgical options can be offered (trapeziectomy and carpometacarpal joint replacement (CMCJR)). However there is a lack of high quality evidence comparing these ...

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This research aims to understand how ageing and blood thinners, widely prescribed to older adults, affect the body’s ability to stop bleeding after injuries like hip fractures. Blood thinners, used to prevent strokes and heart problems, reduce the blood’s ability to clot and are often thought to increase the risk of bleeding during surgery. As a result, doctors sometimes delay surgery for patients on blood thinners to minimise this risk. However, delays can lead to serious complications, including infections and ...

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This is a first-in-human phase 1 trial to assess the safety,tolerability,and immunogenicity of two doses of ChAdOx1 LassaJ in healthy volunteers aged 18-55 years. There will be an initial lead-in cohort (cohort 1) of 6 participants,followed by a participant-observer blinded cohort of 25 participants cohort (cohort 2). Participants in cohort 2 will be randomly assigned to subgroups,one of which will receive 2 doses of the ChAdOx1 LassaJ vaccine 12 weeks apart (20 participants) and the other group will receive ...

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COPD is the third leading cause of deaths worldwide. Lung volume reduction (LVR) therapy improves symptoms and life expectancy in severe COPD. The damaged lungs in COPD become overinflated which may cause compression of the more efficient parts of the lung. One-way expiratory endobronchial valves have been developed to be placed in the airways leading to the overinflated lung by bronchoscopy, only allowing air to exit the lung causing deflation and LVR. In some cases, air can enter the targeted ...

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StratMedPaeds2 aims to develop new tests that identify treatment for children who fail therapy and experience cancer relapse. It builds on the success achieved in StratMedPaeds1, which provided a national pathway to molecularly test tumour tissue and blood in children who relapse, and feed usable information about treatment and mechanisms of treatment failure to clinicians and researchers seeking to improve survival for these children. Having delivered several effective tests to the NHS, StratMedPaeds2 will move on to address four important ...

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Inflammatory skin diseases account for an enormous physical and psychological burden. Although there have been tremendous improvements in the range of available treatments, there remains a major unmet medical need, not least of all because the majority of the advances are only approved for those with the most severe forms of disease. The other 80-90% of affected individuals are largely unable to benefit. Here, we aim to study the immune responses which are involved in driving skin ...

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Head and neck cancer affects the mouth, throat, salivary glands, voice box, nose or sinuses. Every year over 12,000 people get head and neck cancer. It is the 8th most common form of cancer. Over recent years many more people, particularly young people, have developed head and neck cancers. Many of these cancers are removed surgically. Some people also need radiotherapy or chemotherapy. Treatments are improving and better at getting rid of these cancers. Neck dissection is a common operation ...

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Patients with the rare inherited bleeding disorders, afibrinogenaemia and dysfibrinogenaemia commonly require concentrated fibrinogen therapy to treat or prevent bleeding. Recent studies have highlighted that each type of fibrinogen treatment works a little differently, in particular in the degree to which a strong blood clot, that doesn't dissolve rapidly, is formed. We have recently studied the different effects of two commercial fibrinogen concentrates (Riastap®and Fibryga®) on clot formation in a patient with afibrinogenaemia. Our report suggests that the specific choice ...

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This is a study putting together large numbers of patients with or without a hereditary risk of adrenal tumours including tumours such as adrenocortical carcinoma and phaeochromocytoma/paraganglioma. The purpose is to answer questions about the survival of patients with these rare tumours and to do this, we will collect information on diagnosis and management of these tumours. This data will be best assessed by combing these rare cases at a national level recruiting from centres throughout UK and Ireland. The ...

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Millions of people suffer due to cardiac arrest every year and in many cases, the cause of the cardiac arrest is related to a disorder of the electrical activity of the heart. Calcium Release Deficiency Syndrome (CRDS) is a recently discovered electrical heart disorder that develops due to a genetic change in the RyR2 gene resulting in the low activity of RyR2 protein. Currently, CRDS needs genetic testing to be diagnosed and then the identified RyR2 genetic change needs to ...

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