This study is a Phase 3, open-label, multi-center, randomized study to evaluate the efficacy and safety of elranatamab monotherapy versus the investigator’s choice of elotuzumab, pomalidomide, dexamethasone (EPd) or pomalidomide, bortezomib, dexamethasone (PVd) or carfilzomib, dexamethasone (Kd) in participants with RRMM who have received at least 1 but no more than 4 prior lines of therapy including an anti-CD38 antibody and lenalidomide. Participants will have RRMM and relapsed or refractory to the last anti-myeloma treatment regimen and will not have ...

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This is a multi-centre Randomised Controlled Trial that will investigate the feasibility of self-monitoring of hypertension,self-testing for proteinuria and remote titration of medication in a group of pregnant women with hypertension.

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Cirrhosis, progressive scaring of the liver- has many causes, principally, excessive alcohol intake, fatty-liver and viral infections. Unlike many chronic diseases, cirrhosis deaths are increasing rapidly year-on-year. It is the third commonest cause of premature, UK working-age deaths, with 62,000 years of working-life lost each year and NHS care costs of £4.53bn annually. One quarter of all UK cirrhosis patients are at-risk of acute decompensation, whereby complications such as fluid-overload, confusion and infections arise, requiring hospital-emergency treatment. Currently, decompensated cirrhosis patients ...

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Juvenile Idiopathic Arthritis (JIA) is a chronic inflammatory disease affecting 1 in 1000 children with around 12,000 children with JIA in England and Wales [1,2]. Delay in diagnosis and under-treatment lead to joint damage,disability and reduced quality of life [3]. In the UK and most of the world,children and young people with new-onset poly-articular Juvenile Idiopathic Arthritis (pcJIA) are commenced on corticosteroids and methotrexate [2,4,5]. As methotrexate can take several months to have an effect,corticosteroids are used to rapidly control ...

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Nearly 30,000 infants under one are admitted to hospitals in England each year with bronchiolitis, a common viral chest infection. Half of them need oxygen treatment through ‘nasal cannula’ (thin tubes inserted into the nostrils). Most infants respond to nasal cannula oxygen alone, but some need additional breathing support. In these infants, different treatments such as ‘humidified’ (moist) standard oxygen (HSO), high-flow nasal cannula (HFNC) and ‘CPAP’ (pressurised oxygen delivered through the nose) are used. However, it is not clear ...

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Rectal cancer (cancer of the lower part of the bowel) is one of the most prevalent forms of cancer, and affects approximately 14,000 people each year in the UK. The treatment for the majority of these patients is surgical removal of the affected part of the bowel, following which the bowel is joined back together. Some patients may also require chemotherapy and radiotherapy. One consequence of the treatment of bowel cancer is a severe form of bowel dysfunction called major Low Anterior Resection Syndrome ...

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A coronary artery bypass graft (CABG) is a surgical procedure used to treat coronary heart disease. It diverts blood around narrowed or clogged parts of the major arteries to improve blood flow and oxygen supply to the heart. Like all organs in the body, the heart needs a constant supply of blood which comes through arteries called coronaries. Over time, these arteries can become narrowed and hardened by the build-up of fatty deposits called atherosclerosis plaques. CABG involves taking a blood ...

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The hypothesis is that subcutaneous Tocilizumab administered for 12 weeks will improve generic health-related quality of life compared to placebo by reducing systemic inflammation and improving symptoms in adults with Long Covid. Primary outcome - to investigate the effect of 12 weeks of subcutaneous (s/c) Tocilizumab compared to placebo on health-related quality of life Secondary outcomes - to investigate the effect of 12 weeks of s/c Tocilizumab compared to placebo on: 1) Symptoms 2) Mental Health 3) Physical Performance 4) Daily physical activity 5) Cognitive impairment 6) Multi-Organ function 7) Systemic inflammation To investigate the ...

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This is a Phase 3 extension, global, multicenter, OL study to assess the long-term safety and tolerability of tolebrutinib in adult participants (aged ≥18 years) with RMS, PPMS, or NRSPMS who were previously enrolled in the Phase 2b LTS16004 study or 1 of the 4 Phase 3 tolebrutinib pivotal studies (GEMINI 1 [EFC16033], GEMINI 2 [EFC16034], HERCULES [EFC16645], or PERSEUS [EFC16035]). The LTS17043 study includes participants with RMS, PPMS, or NRSPMS who have completed the Phase 2b LTS16004 study or 1 ...

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Our overall research question is: How might Physician Associates help (or not) address the workforce crisis in the NHS and more particularly are they part of the solution in NHS hospitals? This will be a multiple methods study including five activities. • Activity a: Secondary NHS workforce database analysis where we analyse secondary data analysis from publicly available database,Electronic Staff Records (ESR) and NHS trust and health board HR database Our main objectives for activity A are to (1) explore available administrative ...

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