Perthes’ disease is a rare condition of the hip joint and one of the most disabling conditions affecting children. It has a profound impact on the life of the child, and that of their family. Perthes’ disease is caused by a problem with the blood supply to the hip, which means the ball doesn’t get enough oxygen and nutrients to grow. When this happens, the hip loses its strength and flattens. In Perthes’ disease there is a temporary loss of blood ...

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The proposed trial test whether the addition of venetoclax,compared to placebo,with azacitidine and ivosidenib improves outcomes in newly diagnosed adult patients with IDH1 mutated AML,who are not considered candidates for intensive chemotherapy by measuring event free survival.. Newly diagnosed,previously untreated patients ≥18 years of age with IDH1-mutated or IDH1 mutated MDS/AML that are eligible for the study will be randomised in a 1:1 ratio to therapy with ivosidenib /azacitidine with venetoclax or placebo. Treatment will be on a continuous 28-day cycle ...

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A break to the bone of the upper arm at the shoulder is a painful injury. It results in a sudden loss of use of the arm with recovery taking many months. Most injuries occur in people over 50 years of age after a fall, due to reduced bone strength, and are usually treated with a sling, although some fractures may need surgery. Currently, people are asked to see a physiotherapist a number of times to help with recovery after ...

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AIM To explore if it is possible to carry out a study testing a fatigue self-management programme for people who survive an intensive care unit (ICU) admission. WHAT DO WE KNOW? Patients with life-threatening illness require care in an ICU. Approximately half of those who survive (approx. 82,000 per year) report fatigue lasting for a year or more. Fatigue is described as an overwhelming physical and mental exhaustion, not relieved by rest or sleep. Fatigue has a devastating impact on ...

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This will be a prospective, observational, cohort study to evaluate if imaging abdominal organs could help improve clinical care by accurately identifying complications of type 2 diabetes (T2D). Participants with T2D and concurrent diabetic retinopathy will be recruited from Moorfields Hospital NHS Foundation Trust in London. Participants will be treated and assessed in line with normal clinical care. Type 2 diabetes often leads to more complicated diseases. People with T2D could also develop eye, liver disease, chronic kidney disease and cardiovascular ...

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1. Study Objectives The main aim of DARFI is to: - Establish a national collaborative database platform for the study of atypical and rare fractures. - Create a shared platform linking Major Trauma Centres, Trauma Units and District General Hospitals across the UK. - Enable high-quality, large-scale research on rare fracture types that would be impossible to study meaningfully at single centres. - Identify patterns, predictors of poor outcomes, and factors influencing treatment choices (e.g. when early surgery is required or when conservative treatment ...

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Type 1 diabetes (T1D) is a chronic disease, affecting around 1 in 350 children under the age of 15. Treatment is with life-long insulin and is typically started as an emergency when children present with dangerously high glucose (sugar) levels to their doctor. However, T1D has recognised stages before symptoms develop, providing an opportunity for early diagnosis, education and treatment before severe illness. Tests which help diagnose patients and tell doctors when a person may be soon need insulin ...

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Spasticity is an umbrella term for impairments of muscle activity and control in the context of damage or dysfunction in the central nervous system,occurring in up to 87% of spinal cord injury patients (Skoog et al 2020),42% of stroke patients (Wissel et al 2013) and 80% of patients with multiple sclerosis (Rizzo et al 2004). Spasticity results in pain,stiffness,and restrictions to activity including difficulties in personal care and mobility and a significant impact on quality of life (Bihimani et al ...

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Background Paediatric Rheumatology is a term that covers over 80 conditions, affecting different parts of the body, such as Juvenile Arthritis. Children and young people (CYP) with rheumatological conditions can have high levels of mental health problems and therefore are at risk of poor health outcomes. We need to look at novel ways of providing early, essential support, to improve their current wellbeing. Our aims This study will create a digital-service that can guide parents through ways of supporting their CYP at ...

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This study is a multi-centre observational, prospective registry of patients with high-risk neuroblastoma treated with Dinutuximab beta. Pain is an almost universal toxicity associated with anti-GD2 immunotherapy, and can be severe despite opioid analgesia. The aim of the study is to better understand the mechanism of pain is patients receving this immunotherapy, with the ultimate aim of designing better, less toxic anti-GD2 antibodies. The study is non-interventional. All treatment decisions are made according to normal clinical practice and are not ...

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