This is a multicenter RWE study to evaluate the efficacy of etrasimod daily dose of 2 mg in patients with moderately to severely active UC. The study consists of a 52-Week treatment period, and a 28-day safety follow-up period. This prospective, international, non-interventional primary data collection study will be conducted in countries across the world. Countries will be divided into study regions. A country can be a study region on its own. Each study region will start with patient recruitment as soon ...

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What is the problem? Skin cancers are common and the number of people who are developing them is increasing. They are usually split into two groups: melanomas are less common but more serious and keratinocyte skin cancers are more common but less serious. Most need to be cut out. Keratinocyte skin cancers on the leg often cannot be closed with stitches and the wounds are left open to heal by themselves (known as secondary intention wound healing). When left open, they ...

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The overall aim of this research is utilise blood donated from patients on warfarin therapy to aid the development and optimisation of Microvisk’s second generation Prothrombin/International Normalized Ratio (PT/INR) Test System. The donated blood will be used on ongoing development, validation, verification, and calibration projects. Microvisk has developed a small hand-held device which will measure PT/INR from a low volume capillary blood sample. The device is intended for use by both healthcare professionals and for self-testing by the patient. Consenting patients of ...

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Allogeneic hematopoietic cell transplantation (alloHCT) is a well-established therapy for different lifethreatening hematologic malignancies. The use of alloHCT is constantly increasing, with nearly 20 000 transplantations reported to the European Society for Blood and Marrow Transplantation (EBMT) per year. However, this treatment is limited by high morbidity and mortality, mainly related to relapse, infection, graft-versus-host disease (GvHD), and conditioning-related toxicity. Therefore, overall survival (OS) and GvHD-free, relapse-free survival (GRFS) after alloHCT, remain low, around 60% and 30% at one year. Over ...

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Although the optimal treatment strategy in oesophageal (food pipe) cancer has been the subject of research for several decades, overall outcomes are very poor, with a 5-year survival of 15%. In the UK there are 9100 new cases of oesophago-gastric cancer diagnosed and approximately 7925 deaths every year (Cancer Research UK Oct 2019). Oesophageal cancer is a strategic priority for CRUK and a serious health problem world-wide. Pre-surgery treatment consists of chemotherapy or chemoradiation, but the optimal treatment is unknown. ...

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Peripheral artery disease (PAD) is a reduction of blood flow in the legs due to the narrowing or blockage of arteries. The prevalence of vascular calcification in patients with PAD hinders the outcome of endovascular treatments due to increased stiffness of the vessel wall. Treatment failure is especially high in patients with chronic limb-threatening ischemia (CLTI), the most advanced type of PAD, characterized by rest pain and tissue loss. These patients are at a high risk of limb amputation and ...

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The MANTRA trial is an open label, non-blinded, multicentre non-inferiority RCT with an internal pilot comparing the safety and effectiveness of three different surgical prophylaxis antibiotic regimens following surgery for mandible fractures. This is a multicentre trial in secondary care, involving multiple NHS OMFS units treating mandible fractures. We aim to set-up >25 sites over a 3-year trial period. We have provisional participation agreement with >50 sites and written commitment from the only UK specialist association (BAOMS) to promote, support ...

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This is a multicenter, open-label, active control extension study to assess the long-term safety and efficacy of tegoprubart compared with tacrolimus in the preservation of allograft function after kidney transplantation. To be eligible for participation in this study, participants must have completed a designated Parent study. Qualification for this open-label extension (OLE) study will be specified in the Parent study Protocol. Participants who discontinue treatment early or discontinue from the Parent study are not eligible for this OLE study AT-1501-K209. Prospective participants ...

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A Phase 3 Randomized Open-Label Study of Adjuvant Pembrolizumab with or without MK-2870 in Resectable Stage II to IIIB (N2) NSCLC for Participants not Achieving pCR after Receiving Neoadjuvant Pembrolizumab with Platinum based Doublet Chemotherapy Followed by Surgery.

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Each year in the NHS more than 250,000 high risk patients contemplate major surgery. These patients are older and usually have chronic disease. One in three high risk patients who choose surgery will experience will experience medical complications leading to long-term decline in health and quality of life. Awareness of these long term risks is poor amongst both doctors and patient. Consequently, many high-risk patients do not receive the information they need to make an informed decision about surgery. Shared ...

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