Rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis are common forms of inflammatory arthritis. In recent years, special immune-suppressing medicines, called biologics, have been developed, which are very effective in controlling the arthritis disease process and symptoms, but can increase the risk of some infections. People with inflammatory arthritis often need orthopaedic surgery (e.g. joint replacement) to relieve pain and improve function due to the damage caused by arthritis. However, increased risks for surgical site infections is a particular concern ...

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The objectives of the NHS Cancer Vaccine Launchpad (CVLP) are to: 1. Identify cancer patients undergoing resection or biopsy of their tumours who could be eligible for personalised mRNA therapies such as cancer vaccines. 2. Create a pathway for collection and transfer of tumour samples, blood samples and pseudonymised clinical data during routine NHS care. 3. Send samples for DNA extraction, molecular analysis and sequencing initially in partnership with industry (Phase 1) and later to be performed by the NHS Genomic Medicine ...

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When parents face the devastating news during pregnancy that their baby is affected by a life-limiting condition they rely on health care professionals for advice and support. These families are now increasingly being offered antenatal (before birth) palliative care. However, there are a number of ethical challenges to providing antenatal palliative care and there has been very little research in this area. This research aims to better understand the experiences of families in this situation and to examine the ethical ...

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Neuromuscular Diseases (NMDs) affect at least 17 million children and adults globally. They cause either premature death, or are chronic diseases causing lifelong disability with economic impact. They include many different disorders affecting muscle and nerve function, and account for approximately 25% of all non-infectious neurological diseases. Most NMDs are caused by changes to single genes. Identifying these precisely and understanding how they cause disease has already led to some important advances in patient management plans and the development of new ...

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Respiratory distress syndrome (RDS) is a condition commonly found in premature babies that causes breathing difficulty soon after birth. Many babies respond to breathing support alone, but some need surfactant, a liquid drug given into the baby’s airway. Traditionally, the standard method to administer surfactant is through a tube inserted into the airway by the treating doctor. The doctor first needs to visualise the baby’s airway using a laryngoscope (a metal device that holds the airway open), placed into the baby’s mouth and positioned correctly. ...

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The main purpose of this study is to develop measures that capture how Huntington's disease (HD) affects an individual's health and well-being, specifically during the stage of the disease when people have had signs and symptoms for several years. It will also be important to see whether these measures can be completed by the companion participant (either in-person or remotely, e.g. phone) on the HD participant's behalf. The study is made up of two parts. Part 1 will evaluate a modified questionnaire called the ...

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Patients with diabetes have a higher risk of heart attack and worse outcomes. While high glucose levels seem to drive this risk, glucose-lowering medicines do not reduce the risk. Work by Professor Choudhury’s group has shown that high glucose levels lead to re-programming of a type of white blood cell involved in processes such as inflammation, that lead to narrowing of the blood vessels in the heart and consequently heart attack. Specifically, high glucose makes cells in the bone marrow ...

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This is a phase 1b vaccine efficacy study of ID93/GLA-SE in historically BCG-vaccinated and BCG-naive healthy adult volunteers using an aerosol BCG challenge model. There will be four study groups with twelve volunteers in each group (Table 2). Volunteers will be randomised to eligible groups based upon their BCG vaccine status,and will either be given 2 μg ID93 + 5 μg GLA-SE at Day 0 and Day 56 (Group A and C) prior to BCG aerosol challenge,or proceed directly to ...

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von Willebrand disease (vWD) is reported to be the most common bleeding disorder, with prevalence estimated at 1% of the general population. Despite this, little is known about its natural history, or of the impact it has on affected individuals. The Haemnet vWD.360 programme is a mixed-methods, natural history study designed to better understand vWD and its impact on individuals. It comprises both qualitative and quantitative approaches and is designed to include the perspectives of individuals with a diagnosis of ...

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Primary Aim: 1. To assess the bias,precision,limits of agreement and 30% accuracy of eGFR equations compared to measured GFR for people of different ethnicities (e.g. South Asian,Chinese,South-East Asian and Black) in the United Kingdom,compared to people of reported White ethnicity. Design: Retrospective observational data only multi-centre cohort study. Study Population: People with both normal kidney function and chronic kidney disease,who have had a measured GFR test and a paired eGFR test (within 30 days),between 2009 and 2022 inclusively. The study population will include ...

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