Treatments for breast cancer have been increasingly successful. However for patients who have recurrence of their cancer prognosis is still poor. This study will look at patients with treatable cancer that was estrogen receptor positive (ER+) and human epidermal growth factor receptor 2 negative (HER2-). Patients who have completed any surgery, chemotherapy and radiotherapy and are taking long-term endocrine (hormone) therapy will be approached. Participants will undergo up to 3 years of circulating tumour DNA (ctDNA) testing. It ...

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The ASCEND PLUS trial aims assess whether treatment with oral semaglutide reduces the risk of cardiovascular events,and other complications of diabetes,in individuals aged at least 55 years,with type 2 diabetes,without a history of a myocardial infarction or stroke,and without any upper or lower HbA1c threshold. The trial will use mail-based invitation to randomise approximately 20,000 people with type 2 diabetes,and no history of myocardial infarction or stroke,all recruited within the UK and follow them during a scheduled treatment period with ...

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Group B Streptococcus (GBS) is a bacterium (a bug) that causes serious infections in young infants across the world. In 2015 it was estimated that there were at least 319,000 infants under 3 months of age with GBS disease worldwide, resulting in 90,000 deaths and at least 10,000 children with long term disabilities. Around 20% of all pregnant women carry GBS in their vagina and bowel and babies are exposed to GBS bacteria around the time of birth. The options ...

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The primary aim of TARGET National is to establish a national framework to offer molecular profiling of circulating tumor DNA and/or tumour tissue (optional) to patients with advanced solid cancers referred to any of the Experimental Cancer Medicine Centres (ECMCs) across the UK, in order to help decision making for allocation to molecularly targeted experimental cancer treatments. Patients will be allocated treatment using a national Molecular Tumour Board to find the most suited therapies based on their molecular profiling results. ...

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This is a phase II,multicentre,single arm,open label pilot study to assess the safety and efficacy of acalabrutinib in combination with rituximab for previously untreated elderly frail mantle cell lymphoma patients. Patients will receive acalabrutinib and rituximab for up to six cycles. The cycle length is 28 days. Specifically,patients will receive acalabrutinib,orally,at a dose of 100 mg twice daily for 28 days and rituximab 375 mg/m2 intravenously on day 1 (+/-3) of each cycle.* Patients with any degree ...

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Cancer of the oesophagus, the stomach and the bowel are often diagnosed at advanced stage when curative treatment is no longer possible, or can only be achieved by major surgical procedures, often combined with chemo- and radiotherapy, all of which have a huge impact on the patient’s quality of life. Patients with precursor conditions of oesophageal cancer (so-called Barrett Oesophagus) have shown clear benefit from regular surveillance of the respective areas by special camera tests. Both, early detection and treatment ...

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During labour, contractions of the womb squeeze the blood vessels that supply the placenta and decrease the amount of oxygen that reaches the baby. Whilst most babies cope well, a small percentage are at risk of having low levels of oxygen which can have harmful effects, such as brain damage or even death. That is why midwives and doctors monitor babies’ health during labour, most frequently using a cardiotocogram (CTG) – continuous graphs displaying the womb's contractions and the baby's ...

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This is a study of an investigational new drug device combination product of Staccato and alprazolam inhalation powder, called “Staccato® alprazolam”. Staccato alprazolam is a single-use, hand-held, portable device that delivers alprazolam in aerosol form (a fine spray) deep into the lungs through inhalation (breathing in). The purpose of this study is to further assess the long-term effect and safety of Staccato alprazolam in epilepsy patients with previous episodes of prolonged seizures. Participants in this study will be treated on ...

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Monoclonal gammopathy of undetermined significance (MGUS) is the distinct precursor to Multiple Myeloma (MM), a rare blood cancer affecting over 5000 people a year in the UK. Although Myeloma is the only clinical state offered therapy, a small number of MGUS patients suffer complications and these are referred to having monoclonal gammopathy of clinical significance (MGCS). Early detection is a high priority for Myeloma patients and drastically improves survival but has the longest diagnostic delay of any cancer. Most avoidable ...

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The intestinal barrier is a vitally important interface through which an individual will interact with the outside world. In early childhood a number of important events occur in the intestine - immune cells encounter bacteria for the first time, the intestine will be exposed to diet and digestion will begin. Problems with these processes can cause disease, but very little is known about what the normal process is. This is made more challenging due to the scarcity of tissue collected ...

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