Around a quarter of patients with the most common cause of thyroid gland overactivity (Graves' disease) develop a complication known as Graves' orbitopathy (GO). In GO, tissues in the space behind the eyeballs (the orbit) become inflamed, causing pressure to build up. This causes intense pain, restriction of eye movements, and in some cases permanent damage to sight. The pressure causes the eyeballs to bulge forward (proptosis), causing a startled, staring appearance which is disfiguring and a cause of great ...

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The centre of the retina (macula) at the back of the eye contains cells that give us our central vision that we use for reading and recognising faces. These cells can be damaged by a disease called wet age-related macular degeneration (AMD), where new abnormal blood vessels grow through the macula and leak fluid. This can affect vision. In some cases, wet AMD can also cause a bleed under the macula, known as a submacular haemorrhage (SMH), which can lead ...

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This is a non-therapeutic experimental pilot study which aims to recruit up to 19 patients within England. Participants will be identified and approached by a healthcare professional that is part of their clinical care team within the haematology department at Churchill Hospital,Oxford. This study aims to develop 89Zr-belantamab as a PET imaging agent to image BCMA on myeloma cell infiltration. If the imaging agent can reliably demonstrate myeloma deposits,it has several potential applications for drug development and clinical ...

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RESEARCH QUESTION: In post-menopausal women who will not require chemotherapy for >T1,strongly ER+,HER2- invasive breast cancer,does NET improve global HRQoL over 15 months and increase breast BCS rates? Patients will be randomised 1:1 to either the intervention (NET) arm (6 +/- 1 months of NET followed by surgery and adjuvant ET) or the control arm (2-4 weeks of presurgical NET and surgery within 2-4 weeks [up to 8 weeks permitted for trial purposes] followed by adjuvant ET). Both arms will receive ...

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We wish to investigate whether giving deceased organ donors a single dose of the commonly prescribed drug, Simvastatin, is beneficial for transplant recipients.    All donated organs have suffered some damage. As the brain dies chemicals are released which cause an “inflammation” of the body. Measurements of this “inflammation” link to how well the organs function after transplant.  We know that statins have many benefits, including dampening down inflammation in the body and individual organs.  Doctors in Finland linked this information in ...

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The research methodology is based on a single centre observational cohort study,with an internal blinded comparison where each patient acts as their own control. The study is based on the premise of achieving high dimensional prospective data collection in a sufficient number of patients to allow for credible and comprehensive evaluation of the scope of the precision approach and its cost-effectiveness in a specified context of rare cancers. The participants are managed entirely by the standard of care pathway,but consents are obtained ...

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The lack of effective treatments for dementia remains one of the key challenges to modern medicine and society. Its leading cause is Alzheimer’s disease (AD), a condition where proteins (called amyloid and tau) build up in the brain causing inflammation and loss of nerve cells. Importantly, we now know that this process begins decades before first symptoms of dementia appear offering an opportunity to stop it in its tracks with the right treatment. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a ...

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Every year, over one million people in England and Wales suffer a mild Traumatic Brain Injury (TBI) needing hospital care. Bleeding into the brain is a common and serious complication of TBI and older adults are at highest risk. Even a small bleed into the brain can cause disability and some patients can die if the bleeding is more severe. We know that giving a drug called tranexamic acid as an infusion into the vein after a TBI reduces the ...

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Bronchiolitis is a very common winter disease that normally affects children less than one year of age. It is a common reason for parents and carers to bring their child to an Emergency Department (ED) and the frequent need for hospital admission means that paediatric units are at their capacity each winter. During the COVID19 pandemic the virus that causes bronchiolitis (Respiratory Syncytial Virus; RSV) disappeared meaning this winter there have been virtually no cases of bronchiolitis in the ...

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BACKGROUND More older people are undergoing surgery as the population ages and surgical care improves. Frailty is an age-related syndrome that increases an individual's vulnerability to adverse outcomes in response to illness, injury and surgery. Delirium is a period of temporarily altered, fluctuating consciousness, triggered by illness, surgery or environment. There is evidence that surgical outcomes are worse in patients with these conditions. AIMS The purpose of SNAP3 is to investigate which patients are frail and which are at risk ...

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