Hearing loss is a common and disabling condition that may result from problems with the cochlea,the inner ear structure that senses sound and sends information to the brain. Loss of hearing due to damage to the cochlea can occur suddenly and without an obvious cause,a condition described as sudden sensorineural hearing loss (SSNHL). SSNHL can range from a mild hearing loss to a completely deaf ear,which can make it difficult to understand people talking on the affected side. Recovery of ...

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Cytomegalovirus (CMV) is the most frequent cause of congenital infection worldwide, occurring in 0.2-2% of live births. It is also the most frequent cause of non-genetic hearing loss, and an important cause of neurodevelopmental delay. Clinical diagnosis of maternal infection during pregnancy is unreliable in most patients and laboratory diagnosis can be challenging, especially in non-primary infections. Screening of congenital CMV infection (cCMV) in newborns is not recommended in most countries and only targeted screening is performed in some cases (children ...

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A coronary artery bypass graft (CABG) is a surgical procedure used to treat coronary heart disease. It involves taking a blood vessel from another part of the body (usually chest,leg or arm) and attaching it to the coronary artery to improve blood flow to the heart. Some patients will develop an irregular heartbeat (atrial fibrillation (AF)) after CABG surgery. Patients who have AF are at higher risk of developing blood clots that can lead to conditions like stroke and result in ...

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Background A pneumothorax occurs when air gets into the space between the lung and the chest wall, usually through a small hole in the lung. This causes the lung to collapse, and can occur “spontaneously”, meaning without an injury to the chest. Primary spontaneous pneumothorax (PSP) occurs in young patients without known lung disease. 50% of patients with PSP need to have a tube (or drain) inserted into the chest to remove the air between the lung and chest wall, ...

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CLARITY is an observational study whereby participants will attend one 4-hr visit the Division of Cardiovascular Medicine,University of Oxford at the John Radcliffe Hospital in Oxford,with the option to split the study visit over two days for convenience. Of the 200 young adults followed up from the ALSPAC study (G1 offspring cohort),100 will have been born to a hypertensive pregnancy and 100 following an uncomplicated pregnancy. At time of follow-up,they will be 30 to 40 years of age. At the 25-year ...

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This project aims to remotely detect the early signs and symptoms of Parkinson's disease (PD) in a group of patients who carry a gene (glucocerebrosidase-GBA) which causes a genetic predisposition to it. We aim to detect these signs and symptoms prior to the clinically diagnostic onset of the movement related (motor) symptoms of the disease. We will assess for signs and symptoms including anxiety, depression, bradykinesia (slowness of movement), cognitive decline, reduced sense of smell, abnormal sleep behaviours, constipation ...

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High-risk neuroblastoma (HR-NBL). remains one of the areas of unmet need in childhood cancer, as despite improvements in survival, current treatment strategies only cure 40% of patients. The SIOPEN High-Risk Neuroblastoma 2 (HR-NBL2) trial is a pan-European phase 3 randomised clinical trial that aims to improve the outcome of children with HR-NBL It will seek to improve the upfront treatment of this population of children by comparing i) 2 different induction chemotherapy regimens ii) intensifying high dose chemotherapy iii) increasing radiotherapy ...

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This is an observational study of women with and without a previous hypertensive pregnancy. Participants will attend one 4-hr visit at the John Radcliffe Hospital, with the option to split the study visit over two days for convenience. Participants will also be invited to take part in a longer-term follow-up as part of the study. This part of the study does not involve any study visits or further contact with the research team. Instead,we will follow up their health outcome ...

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Malaria is an infectious disease caused by a parasite which is spread by the bite of aninfected mosquito. There were around 240 million cases of malaria and 627,000 deathsworldwide in 2020. There is a great need for a safe,eff ective malaria vaccine and the team atUniversity of Oxford is trying to make vaccine(s) which can prevent serious illness and death. This study is being done to evaluate two experimental malaria vaccines for their safety. Wewill also look at the body’s immune ...

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Objective of the proposed project: The overall objective of the Children’s Surgery Outcome Reporting (CSOR) programme is to investigate whether it is possible to collect paediatric surgical outcomes data using a system that links routinely collected data and parent reported outcome data and provides a platform for centre specific feedback of outcomes in order to reduce unwarranted outcome variation. Why the project is necessary: At present,significant variation exists in the way children with surgical conditions are managed. Some of this variation is ...

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