Ocular inflammatory disease is a broad term for a diverse group of infectious and immune mediated diseases which lead to inflammation in various parts of the eye. Ocular inflammation affects about 1 in 5000 individuals and is the third leading cause of blindness in the western world. Within this umbrella, uveitis is an important and common subtype of ocular inflammation. The term uveitis refers to inflammation of the uveal tract, which is comprised of the iris, ciliary body and choroid. ...

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Acute appendicitis is the most common surgical emergency in children. The lifetime risk of getting appendicitis is 7-8% and the most common age for appendicitis is in the early teens. Appendicectomy is considered the gold standard treatment for acute appendicitis by most surgeons and involves an operation to remove the appendix. Although appendicectomy is usually a simple procedure, it requires a general anaesthetic and there are other risks associated with surgery. Many parents find the idea that their child needs emergency ...

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CiproPAL is a randomised,open-label trial in paediatric patients (1-17 years inclusive) with de-novo Acute Lymphoblastic Leukaemia treated on the existing ALLTogether-1 study (EudraCT 2018-001795-38,REC ref 20/LO/0848,Sponsor: Karolinska University) in the UK. The two main aims of the CiproPAL trial are: 1. To assess the efficacy of ciprofloxacin prophylaxis in reducing infections during the induction phase of the ALLTogether1 Trial. 2. To evaluate the impact of ciprofloxacin prophylaxis on antimicrobial resistance,both in terms of invasive infections and colonising organisms. Patients will be randomised (1:1) ...

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This is a study of an investigational new drug device combination product of Staccato and alprazolam inhalation powder, called “Staccato® alprazolam”. Staccato alprazolam is a single-use, hand-held, portable device that delivers alprazolam in aerosol form (a fine spray) deep into the lungs through inhalation (breathing in). Alprazolam is a drug which acts on the brain and nerves to produce a calming effect. The purpose of this study is to assess the effect and safety of Staccato alprazolam in epilepsy patients with ...

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The retina is the light-sensitive nerve layer that lines the inside of the back of the eye and converts light into electrical signals that is transmitted to the brain via the optic nerve. Inherited retinal diseases (IRDs) are characterised by retinal degeneration associated with genetic mutations. IRDs can affect individuals at any age and progress at different rates with worsening sight or blindness over time. The blinding nature of IRDs, lack of treatment, and complex heterogeneity associated to these conditions ...

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Around a quarter of patients with the most common cause of thyroid gland overactivity (Graves' disease) develop a complication known as Graves' orbitopathy (GO). In GO, tissues in the space behind the eyeballs (the orbit) become inflamed, causing pressure to build up. This causes intense pain, restriction of eye movements, and in some cases permanent damage to sight. The pressure causes the eyeballs to bulge forward (proptosis), causing a startled, staring appearance which is disfiguring and a cause of great ...

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Endometriosis is a common condition which affects one in ten women from puberty to menopause. It causes pelvic pain, poor quality of life and reduces work productivity. It occurs when cells similar to those lining the womb grow outside it, generally within the pelvis. These cells cause internal bleeding at the time of periods, scarring and pain. The condition is diagnosed by laparoscopy (key hole surgery) to identify areas of endometriosis which can be destroyed or removed. Surgery may not provide lasting relief and ...

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The centre of the retina (macula) at the back of the eye contains cells that give us our central vision that we use for reading and recognising faces. These cells can be damaged by a disease called wet age-related macular degeneration (AMD), where new abnormal blood vessels grow through the macula and leak fluid. This can affect vision. In some cases, wet AMD can also cause a bleed under the macula, known as a submacular haemorrhage (SMH), which can lead ...

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This is a non-therapeutic experimental pilot study which aims to recruit up to 19 patients within England. Participants will be identified and approached by a healthcare professional that is part of their clinical care team within the haematology department at Churchill Hospital,Oxford. This study aims to develop 89Zr-belantamab as a PET imaging agent to image BCMA on myeloma cell infiltration. If the imaging agent can reliably demonstrate myeloma deposits,it has several potential applications for drug development and clinical ...

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RESEARCH QUESTION: In post-menopausal women who will not require chemotherapy for >T1,strongly ER+,HER2- invasive breast cancer,does NET improve global HRQoL over 15 months and increase breast BCS rates? Patients will be randomised 1:1 to either the intervention (NET) arm (6 +/- 1 months of NET followed by surgery and adjuvant ET) or the control arm (2-4 weeks of presurgical NET and surgery within 2-4 weeks [up to 8 weeks permitted for trial purposes] followed by adjuvant ET). Both arms will receive ...

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