To understand breast cancer further, we are interested to see how breast cells and cancer cells interact with their environment. There is a growing understanding that the make-up of surrounding tissues (the tumour microenvironment) may trigger different behaviours in breast cancer cells. We know that tumour cells and normal cells sometimes use different fuels and we want to understand these differences further. We also know that conditions related to the metabolism of the patient, i.e. how the body uses ...

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A study to assess clinical phenotype, beta cell function, genetics, and autoantibodies in Extremely Early Type 1 Diabetes (EET1D) to better understand the aetiology and progression of beta cell destruction in Type 1 diabetes (T1D) occurring in the first year of life. As a study of a very rare disease ( < 100 in UK) defined by genetics, it is adopted as a Musketeers' Memorandum Study.

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Preterm birth (< 37 weeks of gestation) is a significant cause of childhood morbidity and mortality, as it is estimated that one million children worldwide die each year of complications of prematurity. Therefore, prevention of morbidities related to preterm birth is considered a central health priority. Two thirds of extremely preterm infants (< 29 weeks of GA) will need intubation and mechanical ventilation (MV) due to lack of surfactant and lack of respiratory drive. Lack of respiratory drive is manifested in ...

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The principal objective of this first three- year phase of BioAID is to recruit at least 10,000 unselected individuals presenting to hospital with signs and symptoms suggestive of infectious disease with consent to store their DNA, RNA, serum and relevant microbiological isolates with linked details of clinical and microbiological phenotype to permit a range of future research into infectious disease. All samples required for BioAID will be derived either from peripheral whole blood or from samples taken for microbiological diagnosis as part of routine ...

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The STELLAR trial will assess the effect of acalabrutinib taken in combination with CHOP-R compared to taking CHOP-R alone in patients with newly diagnosed Richter’s Syndrome (RS). It will also be a platform to test other new drugs that show potential for treating RS. Chronic lymphocytic Leukaemia (CLL) is the most common blood cancer in adults, usually in their 70s or older. In a few patients, CLL can transform from a slow-growing cancer into an aggressive lymphoma called Richter’s ...

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The aims of the program are to investigate recovery of cognitive problems after brain injury and in neurodegenerative patients. The project involves (i) cognitive assessments in the first few weeks after a brain injury. (ii) Follow-up visits with patient-tailored assessments of cognition and mood. (iii) short questionnaires and tests on cognition and mood carried out at home by the carer. The project is carried out by the Cognitive Neuropsychology Centre, which is funded by the Stroke Association UK. This is an observational longitudinal ...

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Throughout the 20th century, the global incidence of pancreatic cancer has steadily increased. It is currently the 4th most common cause of cancer death in Western societies. In the period 1930-1970, the rate of mortality associated with pancreatic cancer doubled in the UK and, as the incidence of the disease continues to rise, it is expected to become the 2nd most common cause of cancer death within a decade. Pancreatic cancer is often diagnosed late and therapy options for patients ...

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Type 1 diabetes (T1D) is a chronic disease affecting around 17 million people worldwide. The disease may present at any age, but most typically develops in early life with a peak around puberty. The scientific insights to the triggering events, disease susceptibility, and subsequent pathophysiological events leading to a failing beta-cell function and beta cell loss (beta cells are found in the pancreas produce insulin)in human T1D are quite limited and disease modifying therapeutic approaches to address T1D ...

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UCL to act as the managing research organisation and central coordinating body for the study and study sponsor. The study (described below) will be active in approximately 12 countries including the UK, USA, Canada, Australia, Germany, Italy and Spain. HDClarity will seek to enroll approximately 600 research participants - 500 of whom will be at different stages of Huntington's disease (HD) and 100 healthy controls. All participants will attend a screening and sampling visit. During the screening visit, medical history, ...

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The aim of our study is to personalise management of high blood pressure for young adults between the ages of 18 to 40 years old. In the UK, at least 1 in 17 adults below the age of 40 have high blood pressure. Controlling the blood pressure in young adults can be a challenge for doctors because information on the management of high blood pressure is mainly obtained from older people. To overcome this challenge, we will study clinical data, ...

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