Hip fracture is one of the biggest challenges facing patients and healthcare systems. Worldwide there are 1.3 million hip fractures with more than 70,000 hip fractures in the UK every year. These figures are projected to rise to more than 6 million by 2050 worldwide.People suffering hip fracture have a 30-day mortality of 7%, a 1-year mortality of 25% and experience a permanent reduction in their health-related quality-of-life similar to that of a patient with Parkinson’s disease or multiple sclerosis. ...

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Coronavirus disease or COVID-19 is a respiratory viral illness which has affected more than a million people globally. Although the illness mostly affects the lungs, some people can develop damage to other organs. The symptoms of this disease can continue for months after the infection. The purpose of this study is to understand the effects of COVID-19 on the health of the lungs, heart, brain, liver and kidney and assess its effects on the quality of life, mental health and ...

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Background: In early 2020, as this protocol was being developed, there were no approved treatments for COVID-19, a disease induced by the novel coronavirus SARS-CoV-2 that emerged in China in late 2019. A range of potential treatments have been suggested for COVID-19 but nobody knows if any of them will turn out to be more effective in helping people recover than the usual standard of hospital care which all patients will receive. The RECOVERY Trial will begin by testing some of ...

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Background: Modifications to existing surgical procedures can have the potential to improve clinical practice and patient outcomes. Modifications commonly occur as part of everyday routine practice. Despite this, little is known about how modifications are initially introduced into practice or what information is communicated to patients about evolving surgical procedures. While it is common for surgeons to make modifications to procedures, it is much less common for them to publish results. When results are published, they tend to be reported ...

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The overgrowth intellectual disability (OGID) syndromes are a family of genetic conditions characterised by increased growth and an intellectual disability. In the last decade many different OGID syndrome genes have been identified. However, we do not understand the full range of OGID clinical associations, the long-term OGID syndrome complications and the cause of the approximately 50% of affected individuals without a genetic diagnosis. We aim to identify new genetic causes of OGID through: a) Interrogating next generation sequencing (NGS) data, obtained ...

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Our genes determine how susceptible we are to life-threatening infection. When a patient is already sick, different genetic factors determine how likely they are to survive. The GenOMICC (Genetics of Susceptibility and Mortality in Critical Care) study will identify the specific genes that cause some people to be susceptible to specific infections and consequences of severe injury. Our hope is that identifying these genes will help us to use existing treatments better, and to design new treatments to help people survive ...

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Tremor can be both physically and socially challenging. By far the two commonest causes are Essential tremor and Parkinson’s. Oral medication is available but many patients eventually discontinue the drugs used for tremor, due to limited efficacy and unacceptable side effects. For those with severe symptoms, deep brain stimulation can be effective. However, this is not without expense, risk or side-effects, and its effectiveness may reduce over time. Accordingly, there is a need for less invasive stimulation approaches than deep ...

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The Tessa Jowell BRAIN MATRIX is a programme of work, the principal purpose of which is to improve the knowledge of, and treatment for, glioma, a type of brain tumour. The programme will include a Platform Study and subsequent interventional clinical trials. This protocol is for the Platform Study, in which a backbone data-repository of disease, treatment and outcome data are collected which will deliver the study’s objectives. Gliomas are the most common primary tumour of the central nervous system (CNS). ...

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This project asks: What is the best technology a surgeon can use to remove as much brain cancer as possible, whilst minimising risk of damage to brain function and improving patient quality of life? For patients with a brain tumour called Glioblastoma (GB) prolonging survival whilst ensuring quality of life are key, but remain challenging. GB is incurable and the most frequent and aggressive form of brain cancer, with an extremely poor prognosis both in quality and length of life. ...

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REMAP-CAP is a trial designed by clinicians who cared for patients and conducted research during the 2009 H1N1 pandemic. Planning began in 2011. REMAP-CAP builds on the combined input of the world’s leading ICU trial networks. These networks have enrolled tens of thousands of patients into trials. They have extensive experience designing, conducting, and reporting clinical trials that enroll patients who are severely ill. Our goal is to generate evidence that can be applied during the pandemic to reduce mortality or reduce ...

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