Progressive Supranuclear Palsy, Corticobasal syndrome and Multiple System Atrophy are degenerative brain conditions. We need better methods of diagnosis and tracking disease progression. This can be improved by: a) detailed clinical study of patients with these diseases; b) study of change in patients’ clinical state over time; c)studying “biomarkers” such as blood or spinal fluid diagnosis or tracking the disease course; and d) including studying “biomarkers” such as blood or spinal fluid diagnosis or tracking the disease course; and d) ...

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Parkinson’s disease (PD) is a progressive, neurodegenerative disorder characterised by the motor symptoms of resting tremor, rigidity, slowness of movement and poor balance. At the time these symptoms first emerge, and the clinical diagnosis of PD can be made, approximately 70% of the dopaminergic brain cells have already been irreversibly lost. Loss of these brain cells, which are critical for movement generation, may begin 5-15 years prior to the onset of first motor symptoms. Early treatment intervention is likely to ...

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An experimental clinical laboratory research study to investigate both the expression levels and the functions of the corresponding defective proteins in fibroblast cell cultures derived from skin biopsies of patients with inherited retinal degenerations. Potential participants will be defined based on their clinical history of inherited retinal disorders and identification of specific gene defects from genetic testing, and will be invited to take part in the study. A skin punch biopsy and matched blood sample will be taken from the ...

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rEECur is a randomised study to compare four chemotherapy regimens to see which is the best at treating recurrent or refractory Ewing sarcoma. Ewing sarcoma is a type of bone cancer. Recurrent Ewing sarcoma means Ewing sarcoma that has come back after being treated. Refractory Ewing sarcoma means Ewing sarcoma that has grown or progressed while being treated. Ewing sarcoma is rare and running a study such as this requires funding and collaboration across many different ...

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The UK MS Register is a ‘real world’ research database designed to increase our understanding of living with MS in the UK. Patients diagnosed with Multiple Sclerosis (MS) according to the McDonald Classification, aged 18 or older, and residing in the UK are eligible to join. We are open to new NHS Sites. Upon consent, a minimum data set can be easily added to our case return form via eCRF for the project. Subsequently, sites provide ongoing longitudinal follow-up data ...

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GENPROS aims to analyse the outcomes of patients with rare gene mutations in the cancer predisposition genes, BRCA1, BRCA2, HOXB13, and Lynch Syndrome, after a diagnosis of and treatment for prostate cancer (PCa). The study includes a cohort of gene mutation carriers with PCa matched with a control group of men with PCa who are known not to carry a mutation in the same gene. Clinical data regarding treatment and patient outcome will be collected retrospectively and prospectively. Archived tumour ...

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Quality of Life (QoL) for people with disabling neurological conditions is affected by a range of factors, which have received considerable previous research attention. However, clinicians’ knowledge could be enhanced by two areas of additional enquiry. 1) Wide consultation: a) Interviewing a range of people with the conditions (First stroke, traumatic brain injury, multiple sclerosis, neuromyelitis optica, spinal conditions, motor neurone disease), about factors influencing QoL; b) Multi-disciplinary Panel- patients and clinicians- experienced in the conditions; c) Draft Questionnaire assessed ...

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Rupture of the anterior cruciate ligament (ACL) and/or meniscal injury is a common and serious knee injury, frequently followed by pain, swelling and episodes of instability. Common problems include recurrent knee instability that can be associated with further cartilage damage causing intermittent swelling or a locking sensation. Furthermore, the injury can lead to poor reported quality of life, decreased activity levels and is associated with increased risk of common arthritis of the knee irrespective of treatment. The management of ACL injuries includes ...

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Adverse drug reactions (ADR's) are a common cause of drug-related morbidity and may account for about 6.5% of all hospital admissions. A meta-analysis of studies performed in the USA has shown that ADRs may be the fourth commonest cause of death. ADRs are also a significant impediment to drug development, and a significant cause of drug withdrawal. The purpose of this research is to (a) identify patients with different types of adverse drug reactions; (b) using DNA obtained from blood ...

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RAIDS is an depth investigation study which provides a unique source of data on road accident causation and consequences, contributing vital evidence to underpin the development and implementation of countermeasures to reduce risk and mitigate injuries. Two main methods of data collection will be employed, on-scene and retrospective examinations. In broad terms, the main objective of the on-scene investigations is to develop information on vehicle primary safety, advanced safety features such as ESC (Electronic Stability Control), the protection offered ...

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