Babies admitted to the Newborn Intensive Care Unit (NICU) are subjected to many invasive, and potentially painful clinical procedures each day as part of their essential medical care. Pain is an important clinical issue, and assessment and management of pain in this vulnerable population presents considerable challenges. Improving our understanding of when and how newborns and premature babies process pain has important consequences for neonatal care. In this Wellcome Trust funded study we aim to investigate the early development of ...

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This project aims to improve short and long term outcomes for children and young people with Wilms (WT) and other childhood renal tumours through the introduction of a more ‘personalised’ approach to risk stratification. This will include biological characterisation of tumour, blood and urine samples to better define the molecular pathways involved, particularly in high risk, ‘blastemal type’ Wilms tumour. There will be central review of tumour pathology and of any imaging studies (scans) performed in ‘real time’, to test ...

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Primary systemic vasculitidies (PSV), encompassing Anti-Neutrophil Cytoplasmic Antibody (ANCA) associated vasculitis and medium vessel vasculitis, are relatively uncommon diseases, but have a propensity for renal involvement and account for a significant number of patients with both acute and chronic kidney disease. The aetiology of PSV is unknown and current therapies are non-specific and associated with major side effects. Outcome data for such patients have comprised small cohort studies from single centres. Understanding the factors that influence disease outcome and the ...

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Is to perform basic research into the causes of arthritis and other inflammatory diseases, and help to develop preventative and therapeutic interventions. We use patient blood and waste tissue from surgical interventions to set up explant cultures to characterise the cells involved in the disease process, identify novel gene signatures and to test new therapies.

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Coronary artery disease (CAD) and its consequences are the leading cause of morbidity and mortality in the UK, leading to major healthcare and economic burdens. Although our understanding of CAD has improved greatly during the last 20 years, there remain major unanswered questions about the fatty deposits (atherosclerotic plaques) in the coronary artery, and how the narrowed or blocked artery causes heart muscle damage. A patient may present with symptoms at any stage of the disease, from chronic narrowing of artery ...

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The Wolfson Laboratories at the Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, have previously undertaken a series of studies using samples of blood and urine from healthy volunteers to investigate the effect of various collection, transport or storage conditions on the concentration of particular components (or on the quality and yield of DNA) and for the validation of laboratory procedures or analytical methods. Separately, CTSU has designed and organised the Study of Heart and Renal Protection ...

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The Pediatric Vasculitis Initiative (PedVas Study) is a project which aims to improve the overall quality of care and health of children with childhood vasculitis by collecting clinical data and biological samples from vasculitis patients all over the world. The initiative is coordinated by the University of British Columbia and funded by the Canadian Institutes of Health Research. In the UK the PedVas study is sponsored by the University of Oxford. The initiative will help us better understand vasculitis and develop ...

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Our study aims to look for new genes and new mutations causing unexplained anaemias in patients who suffer from an inherited anaemia. We have developed in our diagnostic lab a novel high throughput sequencing test simultaneously looking for mutations in 20+ genes that cause inherited anaemias. Patients whose samples are referred for this test and in whom we identify novel or no mutations are invited to participate in the study. The study uses exome/genome sequencing to find new mutations and ...

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This prospective observational cohort study aims to recruit all children with Juvenile Idiopathic Arthritis who are starting therapy with a biologic drug. A parallel cohort of children starting Methotrexate will also be collected. Recruitment and data collection will be facilitated by research nurses established in a number of key paediatric centres across the UK and in particular through collaboration with the MCRN/CLRN and its Local Research Networks (LRN). All children will be followed for a minimum of 5 years. The ...

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Study of immune function in patients with inflammatory arthritis

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