Cardiovascular

ICONIC-M: Improving CRT outcome with non-invasive cardiac mapping A multicentre randomised controlled study to assess patient response to CRT comparing ECGI map-guided left ventricular lead placement with empirical lead placement. (ICONIC-M)

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A register for collecting and measuring outcomes of licensed Anti-Epileptic Drugs and Epilepsy treatments in patients with Epilepsy and Intellectual Disability and/or Pervasive Developmental Disorders (EP-ID Register)

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Cancer and neoplasms

Master Protocol Title: A Master Protocol to Evaluate the Long-Term Safety of Pirtobrutinib - ISA JZ01 Title: Long-Term Safety of Pirtobrutinib in Participants from Study LOXO-BTK-18001 with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non- Hodgkin Lymphoma (J2N-MC-JZNY (ISA: J2N-MC-JZ01))

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Blood Cancer and neoplasms

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Elritercept (KER-050) for the Treatment of Transfusion-Dependent Anemia in Adult Participants with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) (KER-050-D301 (RENEW))

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PROgnosiS Prediction after Enhanced or CriTical care (PROSPECT)

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Blood

Expectations, Lived Experience and Views of a Novel FActor Eight (ELEVATE)

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Cancer and neoplasms

BNT327-03 – A Phase III, multisite, double-blinded randomized trial of BNT327 in combination with chemotherapy (etoposide/carboplatin) compared to atezolizumab in combination with chemotherapy (etoposide/carboplatin) in participants with first-line extensive-stage small-cell lung cancer (BNT327-03)

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A prospective pilot cohort study to investigate the utility and feasibility of using body surface gastric mapping (Gastric Alimetry) to assess gastric motility and function in patients who have undergone elective para-oesophageal hernia repair.

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Musculoskeletal

First-in-human study to assess the safety and feasibility of intra-articular administration of allogeneic engineered gingival fibroblasts (aeGF) in participants with knee osteoarthritis (GF-OA-001)

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Cancer and neoplasms

A Phase 3, Randomized, Open-Label, Multicenter Study to Compare the Efficacy and Safety of Arlocabtagene Autoleucel (BMS-986393), a GPRC5D-directed CAR-T Cell Therapy, Versus Standard Regimens in Adult Participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

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