Cancer and neoplasms

A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial Of Quizartinib Administered In Combination With Induction And Consolidation Chemotherapy And Administered As Maintenance Therapy In Adult Patients With Newly Diagnosed Flt3-Itd Negative Acute Myeloid Leukemia (QuaNTUM-Wild)

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Oral and Gastrointestinal

Prospective non-interventional, phase IV multicentre study to assess the effectiveness, safety and tolerability of elafibranor 80 mg/day in patients with primary biliary cholangitis receiving treatment in a real-world setting. (ELfinity)

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Cancer and neoplasms

A Phase 3 Randomized Double-Blind Multicenter Study of Sonrotoclax Plus Zanubrutinib Versus Placebo Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma (BGB-11417-302 (CELESTIAL-RRMCL))

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Individualised Cryoneurolysis to treat pain in the context of spasticity in the upper and lower Extremities (ICE): a pilot randomised controlled trial (ICE Trial)

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Neurological Reproductive health and childbirth

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study with an Open-Label Extension to Evaluate the Efficacy, Safety, and Tolerability of Atogepant for the Preventive Treatment of Menstrual Migraine

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A Prospective, Screening Study of Bleeding and Treatment in Participants with Von Willebrand Disease

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SAIL Research Database (SAIL)

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Cancer and neoplasms

A Phase 1-2 Master Protocol to Study ATTR-01 in Participants with Selected Advanced Solid Tumours (ATTEST)

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Cancer and neoplasms

A Phase 3, randomized, open-label, multicenter, controlled study to evaluate the efficacy and safety of zanidatamab in combination with physician’s choice chemotherapy compared to trastuzumab in combination with physician’s choice chemotherapy for the treatment of participants with metastatic HER2-positive breast cancer who are ineligible for, intolerant to, or have progressed on previous trastuzumab deruxtecan treatment (EmpowHER 303)

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Pleural blood patch for lung ablation: a randomized trial (Oxford Pleural Embolisation Trial - OxPET) (OxPET)

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