This is a protocol to support primary research into the condition-specific needs of young adults in the UK who store ovarian or testicular tissue after childhood cancer, their parents and the healthcare professionals who provide reproductive survivorship care. This research will be used to help inform the development of a care support tool to help clinical teams look after young adults who store tissue after childhood cancer, and to support their parents/guardians. The tool will be developed and tested in ...

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The Anterior Cruciate Ligament (ACL) is an important band of tissue that supports the knee. It is a strong structure in the centre of the knee which attaches the femur (thigh bone) to the tibia (shin bone). It is often injured during sport. Injury to the ACL can lead to the knee becoming unstable and giving way. An unstable knee can cause damage to other parts of the knee like the cartilage or meniscus (shock absorbers), which can lead to ...

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BACKGROUND Endometrial cancer is the most common gynaecological cancer. The cornerstone of treatment is surgery with adjuvant therapy for women at increased risk of recurrence based on clinico-pathological features. This is imprecise and clinicians and patients must balance the risks of poor survival outcomes with treatment-related toxicity. A new molecular classification system identifies four groups with different prognostic profiles: p53-abnormal (p53abn),POLE-mutant (POLEmut),mismatch repair-deficient (MMRd) and no specific molecular profile (NSMP). The PORTEC-3 trial showed that adjuvant chemoradiotherapy is beneficial for high-risk endometrial cancer patients overall but when ...

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Double-blind,randomised (1:1) placebo-controlled,multi-centre,group-sequential,superiority trial,with internal pilot phase and parallel health economic evaluation. To assess the effectiveness of 26 weeks of treatment with prednisolone vs placebo on disease progression,as measured by the pulmonary function test,forced vital capacity. The change in absolute forced vital capacity (FVC) between baseline and 26 weeks post-randomisation will be compared in patients recently diagnosed with fibrotic hypersensitivity pneumonitis (FHP) and treated with daily prednisolone vs placebo in adults diagnosed with fibrotic hypersensitivity pneumonitis (FHP) within ...

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Anaemia (low blood count) is common in patients who survive ICU. It makes them feel weak and tired. This can lead to longer hospital stays, difficulty in coping at home after leaving hospital and poor quality of life. Expert committees and patient groups have called for research to find the best way to treat anaemia in ICU survivors. We want to see if treating anaemia improves patients’ health after they leave ICU. Our research will test if two treatments – ...

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ROSIER aims to improve treatment for patients after gallstones. We want to find out if patients benefit from having their gallbladder removed after gallstones treatment. Gallstones are solid deposits that form in the gallbladder. When these stones move into the bile duct, they can cause pain and lead to complications, often needing urgent medical treatment. Each year, around 20,000 endoscopic retrograde cholangiopancreatography (ERCP) procedures are performed in England to remove these stones. After ERCP, patients are usually advised to talk ...

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The retina is the layer at the back of the eye that gives sight. Normally it is attached to the wall of the eye, but can separate in a condition called rhegmatogenous retinal detachment(RRD). RRD causes sight loss and requires surgery. The most common surgery to treat a RRD is Vitrectomy however, Vitrectomy can have complications. The most common is cataracts which get worse with time. When they affect vision they need to be removed with surgery. In cataract surgery the foggy lens is changed ...

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This is an open label, observational, experimental medicine study to investigate human immune responses in lymph node cells after immune challenge with a COVID-19 as an intramuscular injection. The study Participants will receive an mRNA COVID-19 booster vaccine and D0 and a seasonal influenza vaccine on Day 28,administered in the arm contralateral to the one used for the COVID vaccine. Participants will then have a fine needle aspiration (FNA) biopsy of axillary lymph nodes on both sides at two timepoints at ...

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The two most common causes of brain injury are stroke and trauma. Both sleep and mental health problems are common after brain injury; we will investigate whether there is a relationship between poor sleep quality and worse mental health in this group. We will follow patients up, at approximately three-monthly intervals until one year after injury, to see how sleep and mental health symptoms change over time and with recovery. We will assess sleep in detail using questionnaires, a sleep monitor ...

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Exercising regularly and is an essential part of managing Type 1 Diabetes, as it improves blood sugar control, reduces insulin requirements and risk of complications of diabetes and also improves cardiovascular and mental health. Despite this, very few people with type 1 diabetes exercise regularly and thus do not get these benefits. Managing glucose levels within safe ranges when exercising remains challenging, particularly for children. Fear of having hypoglycaemic episode (where glucose levels drop dangerously low) is a key barrier ...

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