Aim To find if dexmedetomidine (a painkiller) can help reduce the amount of morphine needed for pain relief in babies who are on a ventilator (a machine which helps babies to breathe). Background Babies born before 37 weeks of pregnancy are premature,but those born before 32 weeks are the most likely to develop problems because of their prematurity. They often need help to breathe which may be given by a ventilator. This can be painful,so doctors give babies painkillers like ...

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Chronic lymphocytic leukaemia (CLL) along with its counterpart small lymphocytic lymphoma (SLL), hereafter referenced as CLL, is a common hematologic malignancy primarily affecting older adults. Historically, chemoimmunotherapy (CIT) has been the cornerstone of CLL treatment; however, its limited efficacy and safety concerns have led to the development of novel targeted therapies. Covalent BTKis (cBTKi) such as ibrutinib and acalabrutinib have been widely adopted, as they have demonstrated superior efficacy and improved safety profiles compared to traditional CIT. For patients with ...

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Hepatitis C Virus currently infects more than 50 million people worldwide and remains a major cause of liver cancer, liver failure and death. This study is the first stage in the development of a human challenge model for hepatitis C Virus infection (HCV), which is needed to test new vaccines that will prevent HCV infection. The purpose of this study is to collect blood from people living with a hepatitis C virus (HCV) infection from sites in the UK which ...

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This is a multi-centre,first-in-human Phase I/IIa dose escalation and dose expansion trial in participants with haematological malignancies. NVG-222 is an autoregulating,half-life extended bispecific ROR1-directed TCE. NVG- 222 will be the first agent to be tested in the clinic that includes an AR mechanism based on granzyme B cleavage. The addition of an IgG1 Fc domain to NVG-222 provides for an extended half-life,allowing a more convenient Q2W dosing regimen compared with continuous IV infusions required for a previous agent NVG-111. The ...

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PIVOTAL is a multi-centre, randomised, Bayesian adaptive platform trial in paediatric intensive care which aims to evaluate multiple important research questions at the same time, with an integrated economic evaluation, internal pilot phase, and patient follow-up at 6 months. The primary platform clinical objective is to investigate the effects of a range of intervention(s) on the ordinal outcome of death or days alive and free from organ support to day 30. The primary platform health economic objective is to investigate the ...

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HIVEC is a Phase III,multi-centre,interventional,single-arm trial assessing the safety and effectiveness of Hyperthermic Intravesical Chemotherapy (HIVEC®) in BCG-unresponsive high-grade non-muscle-invasive bladder cancer (NMIBC) patients. Radical cystectomy has long been considered the standard of care for patients with BCG-unresponsive high-grade NMIBC which if untreated carries a high risk of progression. Many of these patients are elderly where morbidity and mortality associated with cystectomy are significant and cure is not their primary consideration. More recently,pembrolizumab has received FDA approval as an alternative ...

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Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Our work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain ...

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Our aim is to generate the evidence base for improving the care received and patient/family experience for teenagers transitioning from paediatric to adult ICU services. A growing number of children admitted to paediatric intensive care units (ICUs) with chronic conditions and complex needs are later admitted to adult ICUs that often do not know them and are unprepared, compromising care and patient experience at a time of heightened vulnerability. Recent guidelines by the UK Paediatric Critical Care Society (PCCS) and Intensive Care ...

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We would like to know more about cardiovascular abnormalities in patients with immune-mediated inflammatory diseases (IMID) with the aim to provide new biomarkers (clinical, blood, imaging) for early diagnosis, prognosis and prediction of cardiovascular disease (CVD) in patients with IMID. This is important as there are still many unknowns in this area, and finding out more could improve how patients are treated in future. Participants with IMID diagnoses will be recruited from rheumatology/cardiology departments as in-patients or out-patients and categorised into ...

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KRIYA-825-901(OBSERVE) is an observational study of participants with Geographic Atrophy (GA), which is an advance form of age-related macular degeneration. This is a 2-part study run in parallel to the First in Human KRIYA-825-101(VISION) open label study, designed to test how safe, tolerable and effective a gene therapy (VV-14295) is at treating GA. In part 1 of this study investigators review potential participants’ medical charts and retrospective eye examination records since 2022 to determine if they are eligible for the KRIYA-825-101 study. ...

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