The relationship between cabergoline treatment of prolactinoma,the most frequently occurring secretory pituitary tumour and psychiatric side effects remains unclear. Understanding the frequency with which these side effects occur,particularly impulse control disorders and the risk factors for their development is important for healthcare professionals to counsel and monitor patients. This is a prospective study using questionnaires at specific timepoints to investigate psychiatric side effects of cabergoline in patients receiving this for the management of prolactinomas. STUDY OBJECTIVES Primary objective To investigate the ...

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Knee osteoarthritis is a painful condition. In the early stages, patients often benefit from lifestyle changes and exercises. When the knee becomes very damaged, they may require a knee replacement surgery to alleviate the pain and improve symptoms. In between the early and advanced stages, pain can become a major problem. A new treatment has been developed which aims to relieve pain in the knee by blocking (embolisation) small extra blood vessels around the knee. Early studies seem to show ...

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The purpose of this study is to create an ultrasound dataset of sonographer-mother interactions during fetal biometry scans. The dataset will contain ultrasound videos, probe position and orientation (pose), probe accelerations and probe interaction forces as well as infrared/RGB sensor streams and a depth map of the scan area. Data acquisition will be conducted using an instrumented Philips Lumify probe with a Samsung tablet computer for display, as a sonographer performs the scan. The pose of the probe will be ...

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Babies born early or prematurely have under-developed lungs. Many need help with their breathing after birth and some go on to have lifelong lung problems. Premature babies will get infections after discharge which they generally deal with well. The problem is over half get chest infections which further damage the lungs. There are very few treatments available to prevent viral chest infections except against the virus called RSV (Respiratory Syncytial Virus). We want to use a new approach to prepare the babies’ ...

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Assessing cardiac ultrasound imaging (echocardiograms) requires a high level of skill and training for accurate and effective decision-making. The use of artificial intelligence in image analysis has increased in popularity in recent years and aims to reduce human error, reduce variability, and speed up image processing time. We, and others, have developed and have access to various artificial intelligence algorithms and platforms that make use of echocardiogram images and data from these scans to then construct diagnoses or provide severity ...

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This is a multi-center, multinational study of a CE marked Device called the Edwards EVOQUE Transcatheter Tricuspid Valve Replacement used within a routine standard of care setting. This main purpose of the study will be to collect additional data on routine treatment with the Edwards EVOQUE System to expand the available data on the safety and performance of this valve replacement system. The EVOQUE tricuspid valve replacement system is intended for the reduction of tricuspid regurgitation (TR) for patients who remain ...

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This is a Multicenter,prospective,open-label,randomized controlled trial with blinded assessment of endpoints (PROBE) to determine if catheter-based endovascular left atrial appendage occlusion (LAAO) prevents ischemic stroke or systemic embolism in participants with atrial fibrillation (AF),who remain at high risk of stroke,despite receiving ongoing treatment with oral anticoagulation.

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This study will compare the safety and efficacy of two methods of treating benign prostate enlargement (BPE) using prostate artery embolization (PAE), a minimally invasive treatment. PAE helps by blocking the blood flow to the enlarged prostate to shrink it and relieve symptoms like frequent urination or weak flow. Typically, PAE involves injecting small particles called microspheres into the blood vessels feeding the prostate in order to block them so that the restricted blood flow shrinks the prostate. However, this approach ...

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Arthritis of the big toe joint, where the big toe joins the rest of the foot, is very common. It causes pain, swelling and stiffness in the joints, which can often get worse when walking. Living with big toe joint arthritis can affect people’s day to day activities and impact on whether they can work and enjoy other activities and hobbies. We do not know the best way of helping people living with painful big toe arthritis. Some types of ...

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Basal thumb osteoarthritis (BTOA) is a common condition that affects 21% of the population by the age of 40 and 45% by the age of 80. BTOA causes significant problems in this large population with symptoms including pain, tenderness and stiffness. There are a variety of non-surgical and surgical treatments available for BTOA. If non-surgical treatment fails then surgical options can be offered (trapeziectomy and carpometacarpal joint replacement (CMCJR)). However there is a lack of high quality evidence comparing these ...

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