Up to one third of patients undergoing coronary angiography have moderate to severe calcium build-up in their heart arteries. As the population ages, the number of patients with calcified coronary lesions requiring complex percutaneous coronary intervention (PCI) is expected to increase. Calcified arteries make procedures more difficult, often resulting in longer treatment times and poorer outcomes. To improve these outcomes, it is important to prepare the artery by modifying the calcium before placing a stent. Several approved devices are available on ...

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This cognitive function decline study comparing haemodialysis (HD) patients with peritoneal dialysis (PD) patients will be conducted using the DOPPS and PDOPPS (Peritoneal Dialysis Outcomes and Practice Patterns Study) core protocols and infrastructures in the UK. This will allow comparison of change of cognitive function in incident HD and PD patients over time, with the hypothesis that PD is associated with less cognitive impairment (CI) and slower progression of CI than HD.

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Aim To find if dexmedetomidine (a painkiller) can help reduce the amount of morphine needed for pain relief in babies who are on a ventilator (a machine which helps babies to breathe). Background Babies born before 37 weeks of pregnancy are premature,but those born before 32 weeks are the most likely to develop problems because of their prematurity. They often need help to breathe which may be given by a ventilator. This can be painful,so doctors give babies painkillers like ...

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Hepatitis C Virus currently infects more than 50 million people worldwide and remains a major cause of liver cancer, liver failure and death. This study is the first stage in the development of a human challenge model for hepatitis C Virus infection (HCV), which is needed to test new vaccines that will prevent HCV infection. The purpose of this study is to collect blood from people living with a hepatitis C virus (HCV) infection from sites in the UK which ...

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This is a multi-centre,first-in-human Phase I/IIa dose escalation and dose expansion trial in participants with haematological malignancies. NVG-222 is an autoregulating,half-life extended bispecific ROR1-directed TCE. NVG- 222 will be the first agent to be tested in the clinic that includes an AR mechanism based on granzyme B cleavage. The addition of an IgG1 Fc domain to NVG-222 provides for an extended half-life,allowing a more convenient Q2W dosing regimen compared with continuous IV infusions required for a previous agent NVG-111. The ...

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This application is for a health economics analysis alongside the ongoing WHEAT Trial (IRAS 309894). Babies born prematurely are at risk of necrotising enterocolitis (NEC), a serious gut disease that causes over 200 deaths yearly in the UK – about 1 in 20 of all child deaths. Babies who survive NEC often face long-term gut and brain damage. Premature babies are fed milk every few hours and often need blood transfusions for anaemia (low red blood cells). Some doctors worry that ...

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PIVOTAL is a multi-centre, randomised, Bayesian adaptive platform trial in paediatric intensive care which aims to evaluate multiple important research questions at the same time, with an integrated economic evaluation, internal pilot phase, and patient follow-up at 6 months. The primary platform clinical objective is to investigate the effects of a range of intervention(s) on the ordinal outcome of death or days alive and free from organ support to day 30. The primary platform health economic objective is to investigate the ...

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HIVEC is a Phase III,multi-centre,interventional,single-arm trial assessing the safety and effectiveness of Hyperthermic Intravesical Chemotherapy (HIVEC®) in BCG-unresponsive high-grade non-muscle-invasive bladder cancer (NMIBC) patients. Radical cystectomy has long been considered the standard of care for patients with BCG-unresponsive high-grade NMIBC which if untreated carries a high risk of progression. Many of these patients are elderly where morbidity and mortality associated with cystectomy are significant and cure is not their primary consideration. More recently,pembrolizumab has received FDA approval as an alternative ...

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Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Our work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain ...

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Our aim is to generate the evidence base for improving the care received and patient/family experience for teenagers transitioning from paediatric to adult ICU services. A growing number of children admitted to paediatric intensive care units (ICUs) with chronic conditions and complex needs are later admitted to adult ICUs that often do not know them and are unprepared, compromising care and patient experience at a time of heightened vulnerability. Recent guidelines by the UK Paediatric Critical Care Society (PCCS) and Intensive Care ...

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