Title: Cryopreservation of prepubertal testicular tissue for preservation of fertility in young boys with cancer Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys. With informed consent, we aim to cryopreserve (freeze) testis tissue biopsies taken from boys undergoing cancer therapy with a high risk of infertility. A portion of cryopreserved tissue will be securely stored which in the future may be used to ...

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(Diffuse) large B-cell lymphoma (D)LBCL is a cancer of the lymphatic system. Approximately 5,500 people are diagnosed with LBCL per year in the United Kingdom (UK), representing approximately 30-40% of people diagnosed with non-Hodgkin lymphoma (NHL). The usual treatment for patients newly diagnosed with LBCL is a combination of anti-cancer drugs called R-CHOP which are given for approximately 6 months. In practice, around half the patients diagnosed with LBCL are unsuitable for ‘full-dose’ and standard of care R-CHOP or Pola-R-CHP ...

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Each year in the UK, around 37,000 patients have radiotherapy for breast cancer. Radiotherapy uses radiation to kill cancer cells. Radiotherapy is given to the breast and, if needed, to the lymph node regions in daily doses. Until recently most patients needed at least 15 daily treatments of radiotherapy. In addition, around 10,000 women per year in the UK needed up to 8 extra radiation treatments to the part of the breast where the cancer was, resulting in a total ...

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The relationship between cabergoline treatment of prolactinoma,the most frequently occurring secretory pituitary tumour and psychiatric side effects remains unclear. Understanding the frequency with which these side effects occur,particularly impulse control disorders and the risk factors for their development is important for healthcare professionals to counsel and monitor patients. This is a prospective study using questionnaires at specific timepoints to investigate psychiatric side effects of cabergoline in patients receiving this for the management of prolactinomas. STUDY OBJECTIVES Primary objective To investigate the ...

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Children and young people (CYP) with problems with sore joints called Juvenile idiopathic Arthritis (JIA) or problems with their immune system (rheumatological issues) have a range of complaints, such as painful, stiff joints. These problems come and go and can stop CYP attending school. In adulthood, symptoms may affect what job they are able to do. CYP often need to take medications with severe side effects. CYP are usually watched closely to ensure that their medications are working and side ...

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Knee osteoarthritis is a painful condition. In the early stages, patients often benefit from lifestyle changes and exercises. When the knee becomes very damaged, they may require a knee replacement surgery to alleviate the pain and improve symptoms. In between the early and advanced stages, pain can become a major problem. A new treatment has been developed which aims to relieve pain in the knee by blocking (embolisation) small extra blood vessels around the knee. Early studies seem to show ...

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Babies born early or prematurely have under-developed lungs. Many need help with their breathing after birth and some go on to have lifelong lung problems. Premature babies will get infections after discharge which they generally deal with well. The problem is over half get chest infections which further damage the lungs. There are very few treatments available to prevent viral chest infections except against the virus called RSV (Respiratory Syncytial Virus). We want to use a new approach to prepare the babies’ ...

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Basal thumb osteoarthritis (BTOA) is a common condition that affects 21% of the population by the age of 40 and 45% by the age of 80. BTOA causes significant problems in this large population with symptoms including pain, tenderness and stiffness. There are a variety of non-surgical and surgical treatments available for BTOA. If non-surgical treatment fails then surgical options can be offered (trapeziectomy and carpometacarpal joint replacement (CMCJR)). However there is a lack of high quality evidence comparing these ...

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This research aims to understand how ageing and blood thinners, widely prescribed to older adults, affect the body’s ability to stop bleeding after injuries like hip fractures. Blood thinners, used to prevent strokes and heart problems, reduce the blood’s ability to clot and are often thought to increase the risk of bleeding during surgery. As a result, doctors sometimes delay surgery for patients on blood thinners to minimise this risk. However, delays can lead to serious complications, including infections and ...

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This is a first-in-human phase 1 trial to assess the safety,tolerability,and immunogenicity of two doses of ChAdOx1 LassaJ in healthy volunteers aged 18-55 years. There will be an initial lead-in cohort (cohort 1) of 6 participants,followed by a participant-observer blinded cohort of 25 participants cohort (cohort 2). Participants in cohort 2 will be randomly assigned to subgroups,one of which will receive 2 doses of the ChAdOx1 LassaJ vaccine 12 weeks apart (20 participants) and the other group will receive ...

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