Already existing and coded tumor biological material from the lymph node biopsy and personal health-related data of patients who have been diagnosed with NMZL will be collected retrospectively.The value of the expected results of the IELSG52 study are: (i) to inform on diagnosis and prognosis of NMZL; (ii) to allow selection of optimal therapy; and (iii) to provide a biology based framework on which to design and interpret clinical trials

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Hypothesis: Selected treatments that target key neurodegenerative / neuroprotective pathways in PD will slow disease progression compared to placebo. Aims: • To assess the clinical and cost-effectiveness of at least 3 potential disease modifying therapies (DMTs) compared with a shared placebo on the rate of progression of Parkinson's Disease (PD). • To establish sustainable infrastructure for the long-term evaluation of clinical and cost effectiveness of further potential DMTs in PD. • To recruit a representative study population. Methods: • We will recruit 1200 participants from 40 UK sites over ...

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This is a protocol to support primary research into the condition-specific needs of young adults in the UK who store ovarian or testicular tissue after childhood cancer, their parents and the healthcare professionals who provide reproductive survivorship care. This research will be used to help inform the development of a care support tool to help clinical teams look after young adults who store tissue after childhood cancer, and to support their parents/guardians. The tool will be developed and tested in ...

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Every day in the UK, 10 people over 65 years develop kidney failure. More of these older adults are receiving kidney transplants. People with transplants need to take tablets to prevent their bodies from rejecting the transplant(‘immunosuppression’). The immune system becomes less effective in later life, meaning lower doses of immunosuppression tablets may be enough to stop transplant rejection. The amount of immunosuppression medication given to older transplant recipients is currently based on research in young people. Immunosuppression tablets affect older ...

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The Anterior Cruciate Ligament (ACL) is an important band of tissue that supports the knee. It is a strong structure in the centre of the knee which attaches the femur (thigh bone) to the tibia (shin bone). It is often injured during sport. Injury to the ACL can lead to the knee becoming unstable and giving way. An unstable knee can cause damage to other parts of the knee like the cartilage or meniscus (shock absorbers), which can lead to ...

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The overarching aim of the RAISE project is to provide self-management and psychological support for people with rare autoimmune rheumatic diseases; these include systemic lupus erythematosus, vasculitis, scleroderma, myositis and Sjogren’s syndrome. These diseases can affect people of any age and have a negative impact on peoples’ quality of life (social, work and family life). More than 80% of NHS Rheumatology departments do not provide any support to help patients deal with the impact of living with one of these ...

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The retina is the layer at the back of the eye that gives sight. Normally it is attached to the wall of the eye, but can separate in a condition called rhegmatogenous retinal detachment(RRD). RRD causes sight loss and requires surgery. The most common surgery to treat a RRD is Vitrectomy however, Vitrectomy can have complications. The most common is cataracts which get worse with time. When they affect vision they need to be removed with surgery. In cataract surgery the foggy lens is changed ...

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This is an open label, observational, experimental medicine study to investigate human immune responses in lymph node cells after immune challenge with a COVID-19 as an intramuscular injection. The study Participants will receive an mRNA COVID-19 booster vaccine and D0 and a seasonal influenza vaccine on Day 28,administered in the arm contralateral to the one used for the COVID vaccine. Participants will then have a fine needle aspiration (FNA) biopsy of axillary lymph nodes on both sides at two timepoints at ...

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The two most common causes of brain injury are stroke and trauma. Both sleep and mental health problems are common after brain injury; we will investigate whether there is a relationship between poor sleep quality and worse mental health in this group. We will follow patients up, at approximately three-monthly intervals until one year after injury, to see how sleep and mental health symptoms change over time and with recovery. We will assess sleep in detail using questionnaires, a sleep monitor ...

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Exercising regularly and is an essential part of managing Type 1 Diabetes, as it improves blood sugar control, reduces insulin requirements and risk of complications of diabetes and also improves cardiovascular and mental health. Despite this, very few people with type 1 diabetes exercise regularly and thus do not get these benefits. Managing glucose levels within safe ranges when exercising remains challenging, particularly for children. Fear of having hypoglycaemic episode (where glucose levels drop dangerously low) is a key barrier ...

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