Sepsis is a life-threatening emergency that happens when your body's response to an infection damages vital organs which can often lead to death. In the UK, there are about 245,000 sepsis cases leading to around 48,000 deaths each year, making it a leading cause of death in the UK. Despite considerable recent progress, detecting sepsis in the Emergency Department (ED) remains a challenge. Paramedics and ED doctors often miss signs of sepsis, with the current National Early Warning Score which is ...

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IMPEDE-PKD is a global trial evaluating the long-term efficacy of metformin therapy in slowing the rate of kidney function decline in metformin versus placebo treated Autosomal Dominant Polycystic Kidney Disease (ADPKD) subjects. The UK trial is assessing a primary outcome of change in pain severity from randomisation to 24 months measured using an 11 point numerical rating score (NRS) of average pain over the last 14 days in the ADPKD Pain Assessment Tool (APAT). It is a phase III,international,prospective,multicentre,double-blind,parallel group,placebo-controlled,randomised trial. Secondary ...

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The NHS bowel cancer screening check is offered to everyone over the age of 50. This is a home test kit, called a faecal immunochemical test (FIT). It is used to collect a small sample of stool (poo) which is sent to a lab to be checked for tiny amounts of blood. Your GP may also order a FIT if you have had a change in bowel habits or are experiencing abdominal (tummy) pain. In this study we will be ...

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SWEET-PLUS aims to identify determinants of (non-)adherence to CDK4/6 inhibitors for women who have had early stage oestrogen positive breast cancer, and use that information to co-develop an intervention to support women adhere to these drugs alongside endocrine therapy. These drugs have been shown in trials to be effective; they can reduce the risk of the cancer coming back by a quarter (25%) and are associated with improved survival. To get the full benefit of these new medicines, women need to ...

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Already existing and coded tumor biological material from the lymph node biopsy and personal health-related data of patients who have been diagnosed with NMZL will be collected retrospectively.The value of the expected results of the IELSG52 study are: (i) to inform on diagnosis and prognosis of NMZL; (ii) to allow selection of optimal therapy; and (iii) to provide a biology based framework on which to design and interpret clinical trials

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Hypothesis: Selected treatments that target key neurodegenerative / neuroprotective pathways in PD will slow disease progression compared to placebo. Aims: • To assess the clinical and cost-effectiveness of at least 3 potential disease modifying therapies (DMTs) compared with a shared placebo on the rate of progression of Parkinson's Disease (PD). • To establish sustainable infrastructure for the long-term evaluation of clinical and cost effectiveness of further potential DMTs in PD. • To recruit a representative study population. Methods: • We will recruit 1200 participants from 40 UK sites over ...

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This is a protocol to support primary research into the condition-specific needs of young adults in the UK who store ovarian or testicular tissue after childhood cancer, their parents and the healthcare professionals who provide reproductive survivorship care. This research will be used to help inform the development of a care support tool to help clinical teams look after young adults who store tissue after childhood cancer, and to support their parents/guardians. The tool will be developed and tested in ...

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Every day in the UK, 10 people over 65 years develop kidney failure. More of these older adults are receiving kidney transplants. People with transplants need to take tablets to prevent their bodies from rejecting the transplant(‘immunosuppression’). The immune system becomes less effective in later life, meaning lower doses of immunosuppression tablets may be enough to stop transplant rejection. The amount of immunosuppression medication given to older transplant recipients is currently based on research in young people. Immunosuppression tablets affect older ...

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The Anterior Cruciate Ligament (ACL) is an important band of tissue that supports the knee. It is a strong structure in the centre of the knee which attaches the femur (thigh bone) to the tibia (shin bone). It is often injured during sport. Injury to the ACL can lead to the knee becoming unstable and giving way. An unstable knee can cause damage to other parts of the knee like the cartilage or meniscus (shock absorbers), which can lead to ...

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The overarching aim of the RAISE project is to provide self-management and psychological support for people with rare autoimmune rheumatic diseases; these include systemic lupus erythematosus, vasculitis, scleroderma, myositis and Sjogren’s syndrome. These diseases can affect people of any age and have a negative impact on peoples’ quality of life (social, work and family life). More than 80% of NHS Rheumatology departments do not provide any support to help patients deal with the impact of living with one of these ...

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