This project aims to remotely detect the early signs and symptoms of Parkinson's disease (PD) in a group of patients who carry a gene (glucocerebrosidase-GBA) which causes a genetic predisposition to it. We aim to detect these signs and symptoms prior to the clinically diagnostic onset of the movement related (motor) symptoms of the disease. We will assess for signs and symptoms including anxiety, depression, bradykinesia (slowness of movement), cognitive decline, reduced sense of smell, abnormal sleep behaviours, constipation ...

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High-risk neuroblastoma (HR-NBL). remains one of the areas of unmet need in childhood cancer, as despite improvements in survival, current treatment strategies only cure 40% of patients. The SIOPEN High-Risk Neuroblastoma 2 (HR-NBL2) trial is a pan-European phase 3 randomised clinical trial that aims to improve the outcome of children with HR-NBL It will seek to improve the upfront treatment of this population of children by comparing i) 2 different induction chemotherapy regimens ii) intensifying high dose chemotherapy iii) increasing radiotherapy ...

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This is an observational study of women with and without a previous hypertensive pregnancy. Participants will attend one 4-hr visit at the John Radcliffe Hospital, with the option to split the study visit over two days for convenience. Participants will also be invited to take part in a longer-term follow-up as part of the study. This part of the study does not involve any study visits or further contact with the research team. Instead,we will follow up their health outcome ...

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Malaria is an infectious disease caused by a parasite which is spread by the bite of aninfected mosquito. There were around 240 million cases of malaria and 627,000 deathsworldwide in 2020. There is a great need for a safe,eff ective malaria vaccine and the team atUniversity of Oxford is trying to make vaccine(s) which can prevent serious illness and death. This study is being done to evaluate two experimental malaria vaccines for their safety. Wewill also look at the body’s immune ...

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We want to assess the potential benefits of artificial intelligence (AI)-enabled analysis software for characterising 5-30mm lung nodules that have been found incidentally on CT scans. Specifically, we will determine whether use of the software might have improved patients’ outcomes and experience of care when helping doctors estimate the likelihood of a lung nodule being cancerous. We will also determine whether the software can help the NHS avoid unnecessary scans and procedures, increase limited capacity, and save money as a result.

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Objective of the proposed project: The overall objective of the Children’s Surgery Outcome Reporting (CSOR) programme is to investigate whether it is possible to collect paediatric surgical outcomes data using a system that links routinely collected data and parent reported outcome data and provides a platform for centre specific feedback of outcomes in order to reduce unwarranted outcome variation. Why the project is necessary: At present,significant variation exists in the way children with surgical conditions are managed. Some of this variation is ...

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Do patients with hip fracture have better clinical outcomes when a more liberal transfusion practice is used to treat anaemia ? Hip fracture is the most common serious injury in older people. More than 95% of patients have surgery. This surgery is often high-risk as patients may be frail and have other health problems including heart disease and anaemia (a low blood count). Patients may be in hospital for a long time and need rehabilitation. Up to 35% of surviving patients do not return to ...

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Crohn’s is a disease that makes the bowel red, swollen and painful. It is a lifelong disease. Some people get few flare-ups. Other people may have really bad and long lasting symptoms. There is no cure for Crohn’s, but drugs can treat the symptoms. If the drugs do not work surgery may be needed. Whilst surgery can also stop symptoms for a long time, the disease can return. Further drugs and even further surgery may be needed. Many surgeons feel ...

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When menopause occurs in women under the age of 40 it is called Premature Ovarian Insufficiency (POI). The cause is often unknown but may be due to genetic conditions, immune disorders, cancer treatments, or surgery involving the ovaries. The main symptom is absent or very irregular periods. Many women get other menopause symptoms, such as hot flushes and sweats, loss of libido, painful intercourse, mood changes and fatigue. The ability to get pregnant naturally is greatly reduced. In the long-term, ...

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Endoscopic excision has become the preferred way to remove benign polyps in the large bowel (colo-rectum), with significantly reduced risk and cost compared to surgical approach. Endoscopic Mucosal Resection (EMR) is the standard technique of endoscopic excision in the western endoscopy practice. Delayed bleeding (DB) is the most common complication following EMR, and it occurs in 3-12% of cases depending on various patient or polyp related risk factors. To date, there are no established guidelines to mitigate the risk of ...

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