The Anterior Cruciate Ligament (ACL) is an important band of tissue that supports the knee. It is a strong structure in the centre of the knee which attaches the femur (thigh bone) to the tibia (shin bone). It is often injured during sport. Injury to the ACL can lead to the knee becoming unstable and giving way. An unstable knee can cause damage to other parts of the knee like the cartilage or meniscus (shock absorbers), which can lead to ...

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The overarching aim of the RAISE project is to provide self-management and psychological support for people with rare autoimmune rheumatic diseases; these include systemic lupus erythematosus, vasculitis, scleroderma, myositis and Sjogren’s syndrome. These diseases can affect people of any age and have a negative impact on peoples’ quality of life (social, work and family life). More than 80% of NHS Rheumatology departments do not provide any support to help patients deal with the impact of living with one of these ...

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Anaemia (low blood count) is common in patients who survive ICU. It makes them feel weak and tired. This can lead to longer hospital stays, difficulty in coping at home after leaving hospital and poor quality of life. Expert committees and patient groups have called for research to find the best way to treat anaemia in ICU survivors. We want to see if treating anaemia improves patients’ health after they leave ICU. Our research will test if two treatments – ...

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The retina is the layer at the back of the eye that gives sight. Normally it is attached to the wall of the eye, but can separate in a condition called rhegmatogenous retinal detachment(RRD). RRD causes sight loss and requires surgery. The most common surgery to treat a RRD is Vitrectomy however, Vitrectomy can have complications. The most common is cataracts which get worse with time. When they affect vision they need to be removed with surgery. In cataract surgery the foggy lens is changed ...

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This is an open label, observational, experimental medicine study to investigate human immune responses in lymph node cells after immune challenge with a COVID-19 as an intramuscular injection. The study Participants will receive an mRNA COVID-19 booster vaccine and D0 and a seasonal influenza vaccine on Day 28,administered in the arm contralateral to the one used for the COVID vaccine. Participants will then have a fine needle aspiration (FNA) biopsy of axillary lymph nodes on both sides at two timepoints at ...

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The two most common causes of brain injury are stroke and trauma. Both sleep and mental health problems are common after brain injury; we will investigate whether there is a relationship between poor sleep quality and worse mental health in this group. We will follow patients up, at approximately three-monthly intervals until one year after injury, to see how sleep and mental health symptoms change over time and with recovery. We will assess sleep in detail using questionnaires, a sleep monitor ...

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Exercising regularly and is an essential part of managing Type 1 Diabetes, as it improves blood sugar control, reduces insulin requirements and risk of complications of diabetes and also improves cardiovascular and mental health. Despite this, very few people with type 1 diabetes exercise regularly and thus do not get these benefits. Managing glucose levels within safe ranges when exercising remains challenging, particularly for children. Fear of having hypoglycaemic episode (where glucose levels drop dangerously low) is a key barrier ...

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Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded cytosine-adenine-guanine (CAG) repeat in exon 1 on chromosome 4 of the huntingtin gene (HTT). This results in the production of a mutant huntingtin protein with an abnormally long CAG repeat leading to multiple downstream pathogenic effects and selective neuropathology. Those with greater than 39 CAG repeats are certain to develop the disease, while reduced penetrance is seen between 36 and 39 CAG repeats. Most individuals with HD ...

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This is a study putting together large numbers of patients with menopause and other menopause-related conditions to better understand the patient journey. The purpose is to answer questions about the diagnosis and management of menopause, which will be best assessed by combining these cases at a national level with patients recruited from centres throughout UK and Ireland. The information will be confidential and stored in a secure platform. Patients will be approached for consent to gather their data by their ...

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This observational cohort study will mainly use routinely collected data,e.g.,medical history,available laboratory blood/urine results,patient-reported health data,and documented treatment errors/complications of scheduled routine consultations and planned or emergency hospitalisations,with two data collection methods (Figure 1):  First,a retrospective & cross-sectional assessment of variables of interest from the time of study inclusion back to the time of onset and diagnosis of the condition.  Second,a prospective design assessing variables of interest from the time of inclusion up to five years of follow-up. Patients with an ...

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