HIVEC is a Phase III,multi-centre,interventional,single-arm trial assessing the safety and effectiveness of Hyperthermic Intravesical Chemotherapy (HIVEC®) in BCG-unresponsive high-grade non-muscle-invasive bladder cancer (NMIBC) patients. Radical cystectomy has long been considered the standard of care for patients with BCG-unresponsive high-grade NMIBC which if untreated carries a high risk of progression. Many of these patients are elderly where morbidity and mortality associated with cystectomy are significant and cure is not their primary consideration. More recently,pembrolizumab has received FDA approval as an alternative ...

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Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Our work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain ...

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Our aim is to generate the evidence base for improving the care received and patient/family experience for teenagers transitioning from paediatric to adult ICU services. A growing number of children admitted to paediatric intensive care units (ICUs) with chronic conditions and complex needs are later admitted to adult ICUs that often do not know them and are unprepared, compromising care and patient experience at a time of heightened vulnerability. Recent guidelines by the UK Paediatric Critical Care Society (PCCS) and Intensive Care ...

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This study is a cross-sectional, multi-country, observational study involving Adolescent and Adult Patients with Alopecia Areata (AA), Vitiligo, or Hidradenitis Suppurativa (HS) in real-world clinical practice. Both patient-reported and physician-reported outcomes will be documented. Alopecia areata (AA) is a condition that causes patchy hair loss, typically on the scalp, but can also affect other areas such as the eyebrows, beard, or body hair. It’s an autoimmune condition where the immune system mistakenly attacks the hair follicles, leading to sudden hair ...

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KRIYA-825-901(OBSERVE) is an observational study of participants with Geographic Atrophy (GA), which is an advance form of age-related macular degeneration. This is a 2-part study run in parallel to the First in Human KRIYA-825-101(VISION) open label study, designed to test how safe, tolerable and effective a gene therapy (VV-14295) is at treating GA. In part 1 of this study investigators review potential participants’ medical charts and retrospective eye examination records since 2022 to determine if they are eligible for the KRIYA-825-101 study. ...

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Biomarkers for RAtional Investigation for Neurological decision Support in TBI (BRaINS-TBI) is a UK-wide research study focused on improving how doctors assess patients who come to the Emergency Department (ED) after a mild traumatic brain injury (mTBI). Over 1 million people attend EDs each year with head injuries. Most are mild, but some lead to longer-term problems or may worsen. Currently, doctors rely on symptoms and CT scans to make decisions, but this is not always accurate. This study investigates whether ...

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Aortic regurgitation (AR) occurs in approximately 0.4% of all adults, in 1% of individuals aged 65-74 years and 2% of individuals over 70 years of age. Symptomatic patients with chronic severe AR have a poor prognosis and should therefore undergo surgical aortic valve replacement (SAVR) per current guidelines. SAVR is an open-heart surgery that necessitates the use of cardiopulmonary bypass as well as cardiac arrest. This extensive intervention, performed under general anesthesia, can jeopardize vital organ functions, particularly in older patients, potentially ...

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Background Psoriasis affects two million people in the UK. People with obesity are more likely to develop psoriasis, have more severe symptoms, and respond less well to treatment. Losing weight can improve psoriasis, and doctors are advised to suggest this, but few do. Our patient collaborators were unaware of the link between psoriasis and carrying excess weight. People with psoriasis believe what they eat is important but often feel that their doctors do not have the answers to their questions. Aim To ...

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Brain metastases (cancer that has spread from a different part of the body to the brain) from breast cancer are a common, yet devastating, complication with survival times of 3 - 5 months from diagnosis. Currently treatment in this group of patients include surgery, stereotactic radiosurgery (SRS), and whole brain radiotherapy (WBRT). However, most patients will either receive WBRT or no treatment and the number of patients who receive surgery and SRS are lower. As the commonest treatment for ...

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This project aims to improve treatment decision-making when patients are first diagnosed rectal cancer by improving the accuracy of preoperative staging by radiologists using MRI. We aim to improve the accuracy and quality of information given to patients about their disease stage to improve shared decision making, reduce patient side-effects and ensure that patients receive personalised treatment tailored to their prognosis. We will be consenting patients to measure the impact of the current vs novel staging systems on their quality of ...

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