This is an international, multicenter, prospective observational cohort study to describe the management of previously untreated patients with CLL/SLL using I+V treatment in a real-world setting. Participants will be adult patients with a confirmed diagnosis of CLL/SLL requiring first-line treatment, per iwCLL 2018 criteria or at the discretion of the treating physician using I+V treatment in routine clinical practice. The decision to start I+V treatment must have been taken prior to and independently of the patient’s inclusion in the study. All ...

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This multicenter, 2-part study included a Phase 1, open-label, selinexor dose escalation and expansion part (enrollment completed), and a Phase 3, randomized, double-blind, placebo controlled part to evaluate the efficacy and safety of selinexor + ruxolitinib in treatment naïve patients with MF. Phase 1 was an open-label evaluation of the safety and recommended Phase 2 dose (RP2D) of selinexor in combination with ruxolitinib and included a dose escalation (Phase 1a) and a dose expansion part (Phase 1b). Phase 3 is ...

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The overall aim is: Part 1: To determine the efficacy of Pola-Glofit as bridging treatment to CAR-T cell therapy in patients with relapsed or refractory large B cell lymphomas. Part 2: To determine the efficacy of Pola-Glofit in patients with relapsed or refractory large B cell lymphomas who have failed to achieve complete metabolic response,or progressed after CAR-T cell therapy. The primary endpoints are: Part 1: Overall response rate (ORR) (Complete Metabolic Response (CMR) and Partial Metabolic Response (PMR)) after Pola-Glofit but prior to ...

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Study type Multicentre,non-blinded,feasibility randomised controlled trial Aim Feasibility study to assess feasibility of progressing to a full scale trial to evaluate strategies for platelet transfusion in participants with thrombocytopaenia and cancer associated thrombus (CAT) receiving anticoagulation Primary objective To determine the feasibility of designing and recruiting to a full RCT of management in participants with acute cancer-associated thrombosis (developed within 14 days) and thrombocytopaenia. Secondary objectives To determine: • Additional feasibility measures,such as recruitment rate,reasons for non participation in eligible participants and withdrawal rates and participation barriers ...

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This is a multi-national, randomized, double-blinded study to evaluate the safety and effectiveness of AVIM therapy in patients with uncontrolled hypertension with a previously implanted Medtronic Astra/Azure pacemaker. Over 500 participants will be recruited across 100 sites in UK, Europe and US. AVIM is an investigational therapy that can be added to a pacemaker to allow for specific settings that may help with the treatment of hypertension. The study will be performed in three phases, Screening/Run-In, Randomised double-blind and Randomised ...

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Patients with severe illness require life-saving treatment in intensive care units (ICU). During this treatment, patients often need to stay in bed. The combination of severe illness and immobility can have a devastating impact on the patient’s body. Patients discharged from ICU to the ward are weak, tired and malnourished. However, due to pressures on ward based teams, provision of the essential rehabilitation required is inconsistent. This can cause further muscle loss, delays to patients leaving hospital and incomplete ...

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Living with chronic pain can be tough for any young person. But while some young people may experience distressing thoughts, others may not. No young person should face these problems alone. So, it’s important for us to figure out who might be more vulnerable to distress, when, and why. That way, we can be there for them when they need it most. In total, 70 young people with chronic pain (aged 12-19 years) will be invited to take part. Over a ...

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This is a prospective, observational, non-interventional, multi-center, global clinical study of subjects with early to advanced stage STGD1 caused by bi-allelic likely pathogenic or pathogenic variants in the ABCA4 gene, confirmed genotypically by an accredited genotyping laboratory. The study will consist of 6 visits over a 96-week study period: Visit 1 (Screening Visit), Visit 2 (Week 16), Visit 3 (Week 32) Visit 4 (Week 48), Visit 5 (Week 72), and Visit 6 (Week 96). Subjects who discontinue the study early will ...

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Broken ankles in children often involve the area from which the bone grows – the growth plate. Following growth plate injuries, the growth of the main shin bone in the lower leg (the tibia) can be altered permanently, which can cause the bone to not grow at all, or to grow wonky. The younger the child at the time of injury (i.e. the more they have to grow) the worse the problem may get once the child has fully grown. ...

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Survivors of childhood cancer experience impaired health-related quality of life, psychological distress, and pain. A previously developed body mindset intervention has improved health-related quality of life and symptom distress in adult cancer patients. In the current research, we will examine whether a body mindset intervention can instil adaptive body mindsets, boost resilience, and improve physical and psychological functioning in survivors of childhood cancer. Survivors of childhood cancer will be randomised to the body mindset intervention or an active attention control group. ...

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