Biomarkers for RAtional Investigation for Neurological decision Support in TBI (BRaINS-TBI) is a UK-wide research study focused on improving how doctors assess patients who come to the Emergency Department (ED) after a mild traumatic brain injury (mTBI). Over 1 million people attend EDs each year with head injuries. Most are mild, but some lead to longer-term problems or may worsen. Currently, doctors rely on symptoms and CT scans to make decisions, but this is not always accurate. This study investigates whether ...

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Aortic regurgitation (AR) occurs in approximately 0.4% of all adults, in 1% of individuals aged 65-74 years and 2% of individuals over 70 years of age. Symptomatic patients with chronic severe AR have a poor prognosis and should therefore undergo surgical aortic valve replacement (SAVR) per current guidelines. SAVR is an open-heart surgery that necessitates the use of cardiopulmonary bypass as well as cardiac arrest. This extensive intervention, performed under general anesthesia, can jeopardize vital organ functions, particularly in older patients, potentially ...

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Background Psoriasis affects two million people in the UK. People with obesity are more likely to develop psoriasis, have more severe symptoms, and respond less well to treatment. Losing weight can improve psoriasis, and doctors are advised to suggest this, but few do. Our patient collaborators were unaware of the link between psoriasis and carrying excess weight. People with psoriasis believe what they eat is important but often feel that their doctors do not have the answers to their questions. Aim To ...

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This project aims to improve treatment decision-making when patients are first diagnosed rectal cancer by improving the accuracy of preoperative staging by radiologists using MRI. We aim to improve the accuracy and quality of information given to patients about their disease stage to improve shared decision making, reduce patient side-effects and ensure that patients receive personalised treatment tailored to their prognosis. We will be consenting patients to measure the impact of the current vs novel staging systems on their quality of ...

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This is a Phase 2, global, multicenter, long-term safety study designed to assess the safety and tolerability of BHV-7000 in participants with focal refractory epilepsy. Approximately 660 eligible subjects will enter this study after completing the DBP of either the BHV7000-302 or BHV7000- 303 studies. In the opinion of the investigator, subjects must have tolerated BHV7000/placebo, during participation in the DBP of the parent studies, BHV7000-302 or BHV7000-303 to be eligible. Eligible subjects who completed the DBP of the BHV7000-302 study will ...

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This is an National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) clinical trial aiming to investigate a possible new treatment to limit damage to the brain caused by a stroke. Strokes that are caused by a clot blocking an artery in the brain (‘ischaemic’ strokes) starve brain tissue of oxygen and nutrients. Over a short period of time without oxygen, this tissue becomes permanently damaged. We are investigating the effects of a drug that carries extra oxygen, called ...

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This study is designed for the patients with coronary artery disease (CAD) who experience severe chest pain (refractory angina) despite taking the best available medications. These patients also have evidence of reversible Ischemia (reduced blood flow), but they are considered high-risk or unsuitable for heart surgery or other currently available medical procedures aimed at restoring blood flow (revascularization procedures). A heart team, including specialists such as cardiologists and surgeons, helps determine their eligibility for the study. Shockwave Medical, Inc. has developed ...

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Prospective cluster randomised cross-over trial We will conduct a prospective cluster randomised cross-over trial (ABAB/BABA) to assess the impact of an AI fracture detection tool in EDs and MIUs in the UK. The trial will involve installing a CE-approved AI algorithm at each site for six months. Sites will be randomly assigned to begin the trial with the AI algorithm either active ("On") or inactive ("Off") during the first month. Thereafter,the algorithm status will alternate each ...

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The 3P project is the foundational study of the TBI-REPORTER Experimental Medicine Network. It will establish the standardisation of protocols for collaborative research within TBI-REPORTER, and demonstrate the feasibility of recruitment and delivery across multiple TBI research centres. The data and samples that emerge in this protocol will allow us to carry out exploratory pilot analyses to allow the rational design of future interventional studies. Thus, the project has the potential to improve current health care and its delivery at ...

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The study is a non-interventional,observational study focused on sample collection and laboratory-based analyses to investigate the role of placental EVs and soluble factors in maternal and fetal health. The study will focus on understanding the molecular mechanisms underlying Pre-eclampsia (PET),Gestational Diabetes Mellitus (GDM) and Fetal Growth Restriction (FGR) with the ultimate aim of identifying biomarkers and therapeutic targets. Given it’s complex and exploratory nature,the objectives are designed to be flexible allowing for hypothesis refinement as findings emerge. By incorporating a ...

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