The Evoke study is a randomised, double-blind, placebo-controlled trial to evaluate how effective and safe oral semaglutide is in patients with early Alzheimer’s disease. Alzheimer’s disease is a progressive disorder characterised by gradual cognitive and functional decline that ultimately leads to bodily dysfunction and death. Currently available treatments only provide symptomatic relief and there is a significant unmet need for treatments that can lower the rate of disease progression. Oral semaglutide is a Glucagon like peptide 1 receptor agonist (GLP1-RA), which is ...

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Myeloma(MM) is a common bone marrow cancer with over 5,000 patients diagnosed annually in the UK. Patients with MM have cancerous cells in their bone marrow that grow in an uncontrolled fashion and although new treatments have been developed for MM in the last 5 years, it remains an incurable disease, with nearly 3000 deaths yearly. MM is always preceded by defined precursor conditions, known as monoclonal gammopathy of uncertain significance (MGUS) and smouldering myeloma (SMM). However, only 7% of ...

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Previous research has shown certain biological processes may be disturbed in women with high blood pressure in pregnancy. One of these processes involves a molecule called tetrahydrobiopterin (BH4) which is required for the correct functioning of blood vessels. We have seen lower levels of BH4 in both the placenta and the umbilical cord from mothers with high blood pressure as well as lower levels of BH4 in pregnant mice affected by high blood pressure. In both mice and human umbilical ...

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Cancer that begins in the liver (hepatocellular cancer, HCC) is one of the fastest rising and fourth commonest cause of death due to cancer world-wide. HCC usually arises in people with liver cirrhosis. Liver cirrhosis may develop as a result of a number of underlying conditions, all of which lead to scarring (fibrosis) and eventually to cirrhosis. Advanced liver fibrosis (cirrhosis) is the single most important risk factor for the development of HCC Due to the increased risk of HCC, patients ...

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The RADAR trial is a phase III trial investigating whether substituting brentuximab vedotin for bleomycin in standard chemotherapy for patients with previously untreated early stage Hodgkin Lymphoma (HL) can: • Help stop the lymphoma from coming back • Help more people reach a deep remission quickly • Improve patient survival • Cause less lung damage • Reduce the need for radiotherapy, and the rates of radiotherapy-related toxicities such as second cancers and heart disease. The current standard treatment for patients with early stage HL is 3-4 cycles of ABVD chemotherapy (doxorubicin, ...

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The purpose of this work is to produce induced pluripotent stem cells (iPSC) to study rare, genetic forms of craniosynostosis (premature fusion of the cranial sutures of the skull). This would involve obtaining a single blood sample of not more than 24 ml. The purpose of this work is to produce cell types from the patient (such as neural crest cells and mesenchymal stem cells) that have properties that more closely mimic the cells of the cranial sutures than ...

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The Evoke plus study is a randomised, double-blind, placebo-controlled trial to evaluate how effective and safe oral semaglutide is in patients with early Alzheimer’s disease. Alzheimer’s disease is a progressive disorder characterised by gradual cognitive and functional decline that ultimately leads to bodily dysfunction and death. Currently available treatments only provide symptomatic relief and there is a significant unmet need for treatments that can lower the rate of disease progression. Oral semaglutide is a Glucagon like peptide 1 receptor agonist (GLP1-RA), ...

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Age-related-macular-degeneration (AMD) is a very common cause of blindness. Unfortunately,doctors don’t know who will progress to the sight threatening stage of the disease. Some patients progress slowly or not at all and others quickly. We can teach computers to analyse high resolution images of the inside of the eye. We have access to hundreds of thousands of such images from patients with AMD and patients who don’t have AMD. These images allow us to train computers to identify what eye changes ...

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Liver cancer (HCC, hepatocellular cancer) is a major world-wide health problem and is one of the fastest rising and fourth commonest cause of death due to cancer world-wide. HCC usually arises in people with liver cirrhosis as a result of viral infections, alcohol excess and obesity, all of which cause the immune system to attack the liver. Due to the increased risk of HCC, patients with liver cirrhosis usually have ultrasound scans and blood tests bi-annually, so that if a ...

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The majority of patients who suffer a traumatic brain injury (TBI) do not need to stay in hospital overnight. However, some require admission to a specialist hospital, as their injury is more serious. Seizures can be harmful or even fatal, if not treated appropriately. Medications that reduce the risk of seizures are called antiepileptic drugs (AEDs). However, AEDs have side effects, which can affect patients’ quality of life, memory, concentration and general health. Patients with seizures after TBI are typically prescribed ...

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