Rehabilitation of movement after stroke depends on motor learning. Motor learning involves not only improvement during practice but also improvement between sessions, known as consolidation. Consolidation of learning depends on good sleep quality. However, there is growing evidence that sleep is disrupted after stroke and we recently showed that following brain injury, patients with poorer sleep show worse rehabilitation outcomes. This might occur because sleep disruption impairs consolidation directly, or might reflect other factors that influence both sleep and clinical ...

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The overall aim of the trial is to evaluate the efficacy of licensed targeted therapies in unlicensed indications,in rare adult,paediatric and TYA cancers with actionable genomic alterations (including common cancers with rare actionable alterations) and to identify genomic,transcriptomic and immune contextual influences on response to therapy. The ultimate aim is to transition positive findings ...

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Primary central nervous system lymphoma (PCNSL) is a rare type of brain tumour. It is an aggressive type of non-Hodgkin lymphoma that is found only in the brain or spinal cord. PCNSL is often treated with high-doses of chemotherapy. The first treatment doesn’t work for some patients (called ‘refractory’), and the lymphoma can come back (called ‘relapse’). Refractory or relapsed (RR) PCNSL is much more difficult to treat. There is currently no standard treatment for RR-PCNSL and further chemotherapy ...

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This is a pragmatic, a non-interventional, prospective observational cohort study planned to run for 6 years (Includes pregnancy and to the child’s 5th birthday). This study will build on the infrastructure formed as part of the main OPTIMISE:MS study, adding pregnancy-focused pharmacovigilance. Due to the need to contact healthcare providers for information over and above that recorded in the neurological records, this study needs additional approvals to the main study. The pregnancy study will meet the needs ...

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Treatments for breast cancer have been increasingly successful. However for patients who have recurrence of their cancer prognosis is still poor. This study will look at patients with treatable cancer that was estrogen receptor positive (ER+) and human epidermal growth factor receptor 2 negative (HER2-). Patients who have completed any surgery, chemotherapy and radiotherapy and are taking long-term endocrine (hormone) therapy will be approached. Participants will undergo up to 3 years of circulating tumour DNA (ctDNA) testing. It ...

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The ASCEND PLUS trial aims assess whether treatment with oral semaglutide reduces the risk of cardiovascular events,and other complications of diabetes,in individuals aged at least 55 years,with type 2 diabetes,without a history of a myocardial infarction or stroke,and without any upper or lower HbA1c threshold. The trial will use mail-based invitation to randomise approximately 20,000 people with type 2 diabetes,and no history of myocardial infarction or stroke,all recruited within the UK and follow them during a scheduled treatment period with ...

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The primary aim of TARGET National is to establish a national framework to offer molecular profiling of circulating tumor DNA and/or tumour tissue (optional) to patients with advanced solid cancers referred to any of the Experimental Cancer Medicine Centres (ECMCs) across the UK, in order to help decision making for allocation to molecularly targeted experimental cancer treatments. Patients will be allocated treatment using a national Molecular Tumour Board to find the most suited therapies based on their molecular profiling results. ...

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Cancer of the oesophagus, the stomach and the bowel are often diagnosed at advanced stage when curative treatment is no longer possible, or can only be achieved by major surgical procedures, often combined with chemo- and radiotherapy, all of which have a huge impact on the patient’s quality of life. Patients with precursor conditions of oesophageal cancer (so-called Barrett Oesophagus) have shown clear benefit from regular surveillance of the respective areas by special camera tests. Both, early detection and treatment ...

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During labour, contractions of the womb squeeze the blood vessels that supply the placenta and decrease the amount of oxygen that reaches the baby. Whilst most babies cope well, a small percentage are at risk of having low levels of oxygen which can have harmful effects, such as brain damage or even death. That is why midwives and doctors monitor babies’ health during labour, most frequently using a cardiotocogram (CTG) – continuous graphs displaying the womb's contractions and the baby's ...

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This is a study of an investigational new drug device combination product of Staccato and alprazolam inhalation powder, called “Staccato® alprazolam”. Staccato alprazolam is a single-use, hand-held, portable device that delivers alprazolam in aerosol form (a fine spray) deep into the lungs through inhalation (breathing in). The purpose of this study is to further assess the long-term effect and safety of Staccato alprazolam in epilepsy patients with previous episodes of prolonged seizures. Participants in this study will be treated on ...

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