We wish to investigate whether giving deceased organ donors a single dose of the commonly prescribed drug, Simvastatin, is beneficial for transplant recipients.    All donated organs have suffered some damage. As the brain dies chemicals are released which cause an “inflammation” of the body. Measurements of this “inflammation” link to how well the organs function after transplant.  We know that statins have many benefits, including dampening down inflammation in the body and individual organs.  Doctors in Finland linked this information in ...

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The research methodology is based on a single centre observational cohort study,with an internal blinded comparison where each patient acts as their own control. The study is based on the premise of achieving high dimensional prospective data collection in a sufficient number of patients to allow for credible and comprehensive evaluation of the scope of the precision approach and its cost-effectiveness in a specified context of rare cancers. The participants are managed entirely by the standard of care pathway,but consents are obtained ...

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The lack of effective treatments for dementia remains one of the key challenges to modern medicine and society. Its leading cause is Alzheimer’s disease (AD), a condition where proteins (called amyloid and tau) build up in the brain causing inflammation and loss of nerve cells. Importantly, we now know that this process begins decades before first symptoms of dementia appear offering an opportunity to stop it in its tracks with the right treatment. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a ...

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Every year, over one million people in England and Wales suffer a mild Traumatic Brain Injury (TBI) needing hospital care. Bleeding into the brain is a common and serious complication of TBI and older adults are at highest risk. Even a small bleed into the brain can cause disability and some patients can die if the bleeding is more severe. We know that giving a drug called tranexamic acid as an infusion into the vein after a TBI reduces the ...

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Bronchiolitis is a very common winter disease that normally affects children less than one year of age. It is a common reason for parents and carers to bring their child to an Emergency Department (ED) and the frequent need for hospital admission means that paediatric units are at their capacity each winter. During the COVID19 pandemic the virus that causes bronchiolitis (Respiratory Syncytial Virus; RSV) disappeared meaning this winter there have been virtually no cases of bronchiolitis in the ...

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BACKGROUND More older people are undergoing surgery as the population ages and surgical care improves. Frailty is an age-related syndrome that increases an individual's vulnerability to adverse outcomes in response to illness, injury and surgery. Delirium is a period of temporarily altered, fluctuating consciousness, triggered by illness, surgery or environment. There is evidence that surgical outcomes are worse in patients with these conditions. AIMS The purpose of SNAP3 is to investigate which patients are frail and which are at risk ...

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Nicotine replacement therapy (NRT) provides nicotine without toxins contained in cigarette smoke; when used with specialist support, it helps pregnant women stop smoking. The NRT instruction booklet includes use for preloading, reduction and lapse recovery; studies suggest that allowing to smoke and use NRT together helps with stopping. Currently, NHS stop smoking support advises pregnant women not to smoke when using NRT. This study will test whether relaxing this message could help pregnant women to quit and improve babies’ health. The ...

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Scoliosis is a condition affecting children where the spine twists and curves to the side, often developing between the ages of 10 and 15. Doctors try to prevent the curve becoming too large, as this causes distress due to appearance, and problems into adulthood (back pain and problems with the heart/lungs). A brace may be worn in order to stop the curve worsening, but rarely improving it. The most common type of brace, “full-time brace”, is recommended to be worn ...

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This is a first-in-human (FIH), open-label, non-randomised, multicentre, Phase 1 study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of JNJ-75276617 (the study medication) in adult participants with relapsed or refractory acute leukaemia harbouring KMT2A or NPM1 gene alterations. Leukaemia (cancer of the white blood cells) is diagnosed as acute leukaemia when it progresses quickly and aggressively, and usually requires immediate treatment. Acute leukaemia is classified according to the type of white blood cells affected: Acute ...

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The Evoke study is a randomised, double-blind, placebo-controlled trial to evaluate how effective and safe oral semaglutide is in patients with early Alzheimer’s disease. Alzheimer’s disease is a progressive disorder characterised by gradual cognitive and functional decline that ultimately leads to bodily dysfunction and death. Currently available treatments only provide symptomatic relief and there is a significant unmet need for treatments that can lower the rate of disease progression. Oral semaglutide is a Glucagon like peptide 1 receptor agonist (GLP1-RA), which is ...

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