1) To develop functional imaging methods for the diagnosis, management and understanding of tumours in children and young people. 2) To correlate functional imaging with in vitro studies of the biology of tumours, in particular in vitro Magnetic Resonance Spectroscopy (MRS) and tumour genetics.

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Polycystic ovarian syndrome (PCOS) is a condition where women have disrupted hormone levels, which lead to irregular or absent periods, and ovaries that have many small, fluid-filled sacs (known as follicles or cysts). It is the most common hormonal disturbance causing medical problems amongst women worldwide, and somewhere between 4-15% of women between the ages of 15 to 44 years old are estimated to have the condition. PCOS is associated with a range of medical problems including heart disease, high blood ...

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If a person develops kidney failure, the build-up of toxins and fluid can be fatal within a few days if untreated. Patients with kidney failure need either a replacement kidney (kidney transplant) or for the excess fluid and toxins to be removed from the body (dialysis). The commonest form of dialysis involves blood being filtered by a machine to remove toxins and excessive fluid (haemodialysis). This requires a brisk flow of blood through the machine to allow the toxins to ...

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Early stage breast cancer patients with abnormal looking armpit lymph glands on an ultrasound scan will have a sample (needle biopsy) of this lymph gland taken. If the sample shows cancer cells are present, patients are often given chemotherapy before surgery (called neoadjuvant chemotherapy) to shrink these cancer cells before their operation. Currently after chemotherapy, all patients undergo breast surgery (lumpectomy or mastectomy) and treatment to their armpit (either removal of all armpit lymph glands or radiotherapy to the armpit). Neoadjuvant ...

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Whiplash describes an injury to the neck caused by a rapid movement of the head. It often occurs during a motor vehicle collision, causing considerable pain and distress. Most patients are diagnosed with whiplash associated disorder grade-2 (WAD2). Half of these patients develop chronic pain. Current treatments for patients are ineffective. It is difficult to predict which patients will develop chronic pain, and therefore how to manage these patients. The characteristics of pain felt by many patients with WAD2 suggests ...

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Juvenile Idiopathic Arthritis (JIA) is the most common type of arthritis in children. The term idiopathic means “of unknown origin”. There are six subtypes of JIA, systemic JIA is considered an auto inflammatory disease, the other types are considered autoimmune disease. • Systemic JIA • Oligoarticular JIA • Polyarticular JIA • Juvenile psoriatic arthritis • Enthesitis-related JIA • Undifferentiated arthritis The goal of JIA treatment is to reduce inflammation, control pain and improve quality of life. The primary treatments in JIA include nonsteroidal ...

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This is a multi-arm, multi-centre, open label, prospective observational registry of all Terumo Aortic endovascular grafts. The registry is part of Terumo Aortic's Post Market Clinical Follow-up strategy of commercial devices and will provide insight into both the short and long term clinical outcomes of all marketed and custom devices. The registry will provide long term data on device performance in a real world population of patients.

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Head and neck squamous cell carcinoma (HNSCC) is the sixth commonest cancer worldwide. For the past 20 years, head and neck cancer has been associated with 5-year survival rate of 50%. Traditional risk-factors for HNSCC patients have included alcohol consumption and tobacco use. More recently, however, the incidence of HPV-related HNSCC is increasing, in line with the overall rise in the incidence of malignancies associated with HPV infection. In recent years, numerous approaches have shown that the immune system can be ...

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Any patient suspected of having surgically resectable clear cell renal cell carcinoma (ccRCC) (M0/M1) is suitable for screening for WIRE. The study will provide participants with exposure to novel agents as monotherapy and in combination during the period of time between the decision to undergo surgery and resection. This period of time is 4 weeks due to UK cancer targets, during which patients would otherwise remain untreated. The aim of WIRE is to determine if the novel agents will deliver ...

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The Champion AF study is designed to determine if left atrial appendage closure with the WATCHMAN FLX Device is a reasonable alternative to Direct Oral Anticoagulant (NOACs) in patients with non-valvular atrial fibrillation. Patients in this study will be randomized to either receive the WATCHMAN FLX Device or a course of NOACs patients will be assessed over a period of up to 5 years.

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