Age-related-macular-degeneration (AMD) is a very common cause of blindness. Unfortunately,doctors don’t know who will progress to the sight threatening stage of the disease. Some patients progress slowly or not at all and others quickly. We can teach computers to analyse high resolution images of the inside of the eye. We have access to hundreds of thousands of such images from patients with AMD and patients who don’t have AMD. These images allow us to train computers to identify what eye changes ...

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The majority of patients who suffer a traumatic brain injury (TBI) do not need to stay in hospital overnight. However, some require admission to a specialist hospital, as their injury is more serious. Seizures can be harmful or even fatal, if not treated appropriately. Medications that reduce the risk of seizures are called antiepileptic drugs (AEDs). However, AEDs have side effects, which can affect patients’ quality of life, memory, concentration and general health. Patients with seizures after TBI are typically prescribed ...

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1) To develop functional imaging methods for the diagnosis, management and understanding of tumours in children and young people. 2) To correlate functional imaging with in vitro studies of the biology of tumours, in particular in vitro Magnetic Resonance Spectroscopy (MRS) and tumour genetics.

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The base of thumb joint can commonly be affected by osteoarthritis (OA). This can lead to pain, stiffness, swelling, and difficulty performing activities such as writing, opening jars, or turning keys. Treatment options may include advice on lifestyle factors that may contribute, hand exercises, pain relief such as anti-inflammatory gels or paracetamol, splints, and steroid injections. A surgical procedure called a trapeziectomy (removal of the trapezium bone at the base of the thumb) may be performed where there is ongoing ...

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Polycystic ovarian syndrome (PCOS) is a condition where women have disrupted hormone levels, which lead to irregular or absent periods, and ovaries that have many small, fluid-filled sacs (known as follicles or cysts). It is the most common hormonal disturbance causing medical problems amongst women worldwide, and somewhere between 4-15% of women between the ages of 15 to 44 years old are estimated to have the condition. PCOS is associated with a range of medical problems including heart disease, high blood ...

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If a person develops kidney failure, the build-up of toxins and fluid can be fatal within a few days if untreated. Patients with kidney failure need either a replacement kidney (kidney transplant) or for the excess fluid and toxins to be removed from the body (dialysis). The commonest form of dialysis involves blood being filtered by a machine to remove toxins and excessive fluid (haemodialysis). This requires a brisk flow of blood through the machine to allow the toxins to ...

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Early stage breast cancer patients with abnormal looking armpit lymph glands on an ultrasound scan will have a sample (needle biopsy) of this lymph gland taken. If the sample shows cancer cells are present, patients are often given chemotherapy before surgery (called neoadjuvant chemotherapy) to shrink these cancer cells before their operation. Currently after chemotherapy, all patients undergo breast surgery (lumpectomy or mastectomy) and treatment to their armpit (either removal of all armpit lymph glands or radiotherapy to the armpit). Neoadjuvant ...

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Whiplash describes an injury to the neck caused by a rapid movement of the head. It often occurs during a motor vehicle collision, causing considerable pain and distress. Most patients are diagnosed with whiplash associated disorder grade-2 (WAD2). Half of these patients develop chronic pain. Current treatments for patients are ineffective. It is difficult to predict which patients will develop chronic pain, and therefore how to manage these patients. The characteristics of pain felt by many patients with WAD2 suggests ...

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Juvenile Idiopathic Arthritis (JIA) is the most common type of arthritis in children. The term idiopathic means “of unknown origin”. There are six subtypes of JIA, systemic JIA is considered an auto inflammatory disease, the other types are considered autoimmune disease. • Systemic JIA • Oligoarticular JIA • Polyarticular JIA • Juvenile psoriatic arthritis • Enthesitis-related JIA • Undifferentiated arthritis The goal of JIA treatment is to reduce inflammation, control pain and improve quality of life. The primary treatments in JIA include nonsteroidal ...

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This is a multi-arm, multi-centre, open label, prospective observational registry of all Terumo Aortic endovascular grafts. The registry is part of Terumo Aortic's Post Market Clinical Follow-up strategy of commercial devices and will provide insight into both the short and long term clinical outcomes of all marketed and custom devices. The registry will provide long term data on device performance in a real world population of patients.

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