If a person develops kidney failure, the build-up of toxins and fluid can be fatal within a few days if untreated. Patients with kidney failure need either a replacement kidney (kidney transplant) or for the excess fluid and toxins to be removed from the body (dialysis). The commonest form of dialysis involves blood being filtered by a machine to remove toxins and excessive fluid (haemodialysis). This requires a brisk flow of blood through the machine to allow the toxins to ...

GO TO STUDY

Early stage breast cancer patients with abnormal looking armpit lymph glands on an ultrasound scan will have a sample (needle biopsy) of this lymph gland taken. If the sample shows cancer cells are present, patients are often given chemotherapy before surgery (called neoadjuvant chemotherapy) to shrink these cancer cells before their operation. Currently after chemotherapy, all patients undergo breast surgery (lumpectomy or mastectomy) and treatment to their armpit (either removal of all armpit lymph glands or radiotherapy to the armpit). Neoadjuvant ...

GO TO STUDY

Whiplash describes an injury to the neck caused by a rapid movement of the head. It often occurs during a motor vehicle collision, causing considerable pain and distress. Most patients are diagnosed with whiplash associated disorder grade-2 (WAD2). Half of these patients develop chronic pain. Current treatments for patients are ineffective. It is difficult to predict which patients will develop chronic pain, and therefore how to manage these patients. The characteristics of pain felt by many patients with WAD2 suggests ...

GO TO STUDY

Juvenile Idiopathic Arthritis (JIA) is the most common type of arthritis in children. The term idiopathic means “of unknown origin”. There are six subtypes of JIA, systemic JIA is considered an auto inflammatory disease, the other types are considered autoimmune disease. • Systemic JIA • Oligoarticular JIA • Polyarticular JIA • Juvenile psoriatic arthritis • Enthesitis-related JIA • Undifferentiated arthritis The goal of JIA treatment is to reduce inflammation, control pain and improve quality of life. The primary treatments in JIA include nonsteroidal ...

GO TO STUDY

This is a multi-arm, multi-centre, open label, prospective observational registry of all Terumo Aortic endovascular grafts. The registry is part of Terumo Aortic's Post Market Clinical Follow-up strategy of commercial devices and will provide insight into both the short and long term clinical outcomes of all marketed and custom devices. The registry will provide long term data on device performance in a real world population of patients.

GO TO STUDY

Head and neck squamous cell carcinoma (HNSCC) is the sixth commonest cancer worldwide. For the past 20 years, head and neck cancer has been associated with 5-year survival rate of 50%. Traditional risk-factors for HNSCC patients have included alcohol consumption and tobacco use. More recently, however, the incidence of HPV-related HNSCC is increasing, in line with the overall rise in the incidence of malignancies associated with HPV infection. In recent years, numerous approaches have shown that the immune system can be ...

GO TO STUDY

Any patient suspected of having surgically resectable clear cell renal cell carcinoma (ccRCC) (M0/M1) is suitable for screening for WIRE. The study will provide participants with exposure to novel agents as monotherapy and in combination during the period of time between the decision to undergo surgery and resection. This period of time is 4 weeks due to UK cancer targets, during which patients would otherwise remain untreated. The aim of WIRE is to determine if the novel agents will deliver ...

GO TO STUDY

The Champion AF study is designed to determine if left atrial appendage closure with the WATCHMAN FLX Device is a reasonable alternative to Direct Oral Anticoagulant (NOACs) in patients with non-valvular atrial fibrillation. Patients in this study will be randomized to either receive the WATCHMAN FLX Device or a course of NOACs patients will be assessed over a period of up to 5 years.

GO TO STUDY

Acute Lymphoblastic Leukaemia (ALL) is the commonest cancer of children and young adults with over 400 cases diagnosed each year in the UK. While over 90% of children with ALL are cured, some people’s disease is harder to treat than others. ALLTogether1 investigates whether treatment can be reduced for children with the highest chance of cure, and whether the addition of new drugs improves the chance of cure for those whose disease is most likely to relapse. In the UK, ...

GO TO STUDY

Inhibitor development is the most serious treatment-related complication of replacement coagulation factor VIII (FVIII) therapy for patients with haemophilia A. Immune tolerance induction (ITI), which involves intensive treatment with plasma-derived (pdFVIII) or recombinant FVIII (rFVIII), is the only clinically proven strategy for eradication of inhibitors. The bispecific antibody emicizumab is approved for use in patients with and without inhibitors to prevent bleeding but does not eliminate inhibitors. MOTIVATE aims to capture different approaches to the treatment and management of patients ...

GO TO STUDY