SWEET-PLUS aims to identify determinants of (non-)adherence to CDK4/6 inhibitors for women who have had early stage oestrogen positive breast cancer, and use that information to co-develop an intervention to support women adhere to these drugs alongside endocrine therapy. These drugs have been shown in trials to be effective; they can reduce the risk of the cancer coming back by a quarter (25%) and are associated with improved survival. To get the full benefit of these new medicines, women need to ...

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Already existing and coded tumor biological material from the lymph node biopsy and personal health-related data of patients who have been diagnosed with NMZL will be collected retrospectively.The value of the expected results of the IELSG52 study are: (i) to inform on diagnosis and prognosis of NMZL; (ii) to allow selection of optimal therapy; and (iii) to provide a biology based framework on which to design and interpret clinical trials

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Developmental Dysplasia of the Hip (DDH) is a condition where a baby’s hip joint does not develop properly. The hip may be slightly or completely out of place. Around 1 in 100 babies are affected. The most common treatment is a Pavlik harness, a soft brace that holds the hips in the correct position while they develop. There is currently no clear agreement on the best way to stop treatment with the harness. Some doctors recommend removing the brace all at ...

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Hypothesis: Selected treatments that target key neurodegenerative / neuroprotective pathways in PD will slow disease progression compared to placebo. Aims: • To assess the clinical and cost-effectiveness of at least 3 potential disease modifying therapies (DMTs) compared with a shared placebo on the rate of progression of Parkinson's Disease (PD). • To establish sustainable infrastructure for the long-term evaluation of clinical and cost effectiveness of further potential DMTs in PD. • To recruit a representative study population. Methods: • We will recruit 1200 participants from 40 UK sites over ...

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This is a protocol to support primary research into the condition-specific needs of young adults in the UK who store ovarian or testicular tissue after childhood cancer, their parents and the healthcare professionals who provide reproductive survivorship care. This research will be used to help inform the development of a care support tool to help clinical teams look after young adults who store tissue after childhood cancer, and to support their parents/guardians. The tool will be developed and tested in ...

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Every day in the UK, 10 people over 65 years develop kidney failure. More of these older adults are receiving kidney transplants. People with transplants need to take tablets to prevent their bodies from rejecting the transplant(‘immunosuppression’). The immune system becomes less effective in later life, meaning lower doses of immunosuppression tablets may be enough to stop transplant rejection. The amount of immunosuppression medication given to older transplant recipients is currently based on research in young people. Immunosuppression tablets affect older ...

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The Anterior Cruciate Ligament (ACL) is an important band of tissue that supports the knee. It is a strong structure in the centre of the knee which attaches the femur (thigh bone) to the tibia (shin bone). It is often injured during sport. Injury to the ACL can lead to the knee becoming unstable and giving way. An unstable knee can cause damage to other parts of the knee like the cartilage or meniscus (shock absorbers), which can lead to ...

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Double-blind,randomised (1:1) placebo-controlled,multi-centre,group-sequential,superiority trial,with internal pilot phase and parallel health economic evaluation. To assess the effectiveness of 26 weeks of treatment with prednisolone vs placebo on disease progression,as measured by the pulmonary function test,forced vital capacity. The change in absolute forced vital capacity (FVC) between baseline and 26 weeks post-randomisation will be compared in patients recently diagnosed with fibrotic hypersensitivity pneumonitis (FHP) and treated with daily prednisolone vs placebo in adults diagnosed with fibrotic hypersensitivity pneumonitis (FHP) within ...

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Anaemia (low blood count) is common in patients who survive ICU. It makes them feel weak and tired. This can lead to longer hospital stays, difficulty in coping at home after leaving hospital and poor quality of life. Expert committees and patient groups have called for research to find the best way to treat anaemia in ICU survivors. We want to see if treating anaemia improves patients’ health after they leave ICU. Our research will test if two treatments – ...

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ROSIER aims to improve treatment for patients after gallstones. We want to find out if patients benefit from having their gallbladder removed after gallstones treatment. Gallstones are solid deposits that form in the gallbladder. When these stones move into the bile duct, they can cause pain and lead to complications, often needing urgent medical treatment. Each year, around 20,000 endoscopic retrograde cholangiopancreatography (ERCP) procedures are performed in England to remove these stones. After ERCP, patients are usually advised to talk ...

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