Title: Cryopreservation of prepubertal testicular tissue for preservation of fertility in young boys with cancer Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys. With informed consent, we aim to cryopreserve (freeze) testis tissue biopsies taken from boys undergoing cancer therapy with a high risk of infertility. A portion of cryopreserved tissue will be securely stored which in the future may be used to ...

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(Diffuse) large B-cell lymphoma (D)LBCL is a cancer of the lymphatic system. Approximately 5,500 people are diagnosed with LBCL per year in the United Kingdom (UK), representing approximately 30-40% of people diagnosed with non-Hodgkin lymphoma (NHL). The usual treatment for patients newly diagnosed with LBCL is a combination of anti-cancer drugs called R-CHOP which are given for approximately 6 months. In practice, around half the patients diagnosed with LBCL are unsuitable for ‘full-dose’ and standard of care R-CHOP or Pola-R-CHP ...

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Each year in the UK, around 37,000 patients have radiotherapy for breast cancer. Radiotherapy uses radiation to kill cancer cells. Radiotherapy is given to the breast and, if needed, to the lymph node regions in daily doses. Until recently most patients needed at least 15 daily treatments of radiotherapy. In addition, around 10,000 women per year in the UK needed up to 8 extra radiation treatments to the part of the breast where the cancer was, resulting in a total ...

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The overall aims of the study are: •To determine if the combination of iberdomide and isatuximab with dexamethasone is safe and well tolerated •To determine if the treatment is efficacious in inducing disease response in high-risk smouldering myeloma,thus preventing the development of active multiple myeloma The primary endpoints are: •Treatment deliverability,measured by treatment discontinuation before completion of 26 cycles •Efficacy measured by best overall response rate =by the end of treatment The secondary endpoints are: •Progression Free Survival •Time to biochemical progression •Progression Free Survival 2 •Best ...

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Rheumatoid Arthritis (RA) is a condition that causes joint inflammation which leads to joint deformity and long-term disability. It affects 580,000 adults in England and costs £1.8 billion per year to the UK economy due to work-related disability. Biologic treatments are available for patients with severe disease who do not respond to first-line anti-rheumatic medications. However, only a proportion of patients with inflammatory arthritis respond to these expensive treatments, which results in unnecessary treatment and significant cost to the National Health ...

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The relationship between cabergoline treatment of prolactinoma,the most frequently occurring secretory pituitary tumour and psychiatric side effects remains unclear. Understanding the frequency with which these side effects occur,particularly impulse control disorders and the risk factors for their development is important for healthcare professionals to counsel and monitor patients. This is a prospective study using questionnaires at specific timepoints to investigate psychiatric side effects of cabergoline in patients receiving this for the management of prolactinomas. STUDY OBJECTIVES Primary objective To investigate the ...

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Knee osteoarthritis is a painful condition. In the early stages, patients often benefit from lifestyle changes and exercises. When the knee becomes very damaged, they may require a knee replacement surgery to alleviate the pain and improve symptoms. In between the early and advanced stages, pain can become a major problem. A new treatment has been developed which aims to relieve pain in the knee by blocking (embolisation) small extra blood vessels around the knee. Early studies seem to show ...

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Babies born early or prematurely have under-developed lungs. Many need help with their breathing after birth and some go on to have lifelong lung problems. Premature babies will get infections after discharge which they generally deal with well. The problem is over half get chest infections which further damage the lungs. There are very few treatments available to prevent viral chest infections except against the virus called RSV (Respiratory Syncytial Virus). We want to use a new approach to prepare the babies’ ...

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Assessing cardiac ultrasound imaging (echocardiograms) requires a high level of skill and training for accurate and effective decision-making. The use of artificial intelligence in image analysis has increased in popularity in recent years and aims to reduce human error, reduce variability, and speed up image processing time. We, and others, have developed and have access to various artificial intelligence algorithms and platforms that make use of echocardiogram images and data from these scans to then construct diagnoses or provide severity ...

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This is a multi-center, multinational study of a CE marked Device called the Edwards EVOQUE Transcatheter Tricuspid Valve Replacement used within a routine standard of care setting. This main purpose of the study will be to collect additional data on routine treatment with the Edwards EVOQUE System to expand the available data on the safety and performance of this valve replacement system. The EVOQUE tricuspid valve replacement system is intended for the reduction of tricuspid regurgitation (TR) for patients who remain ...

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