Assessing cardiac ultrasound imaging (echocardiograms) requires a high level of skill and training for accurate and effective decision-making. The use of artificial intelligence in image analysis has increased in popularity in recent years and aims to reduce human error, reduce variability, and speed up image processing time. We, and others, have developed and have access to various artificial intelligence algorithms and platforms that make use of echocardiogram images and data from these scans to then construct diagnoses or provide severity ...

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Arthritis of the big toe joint, where the big toe joins the rest of the foot, is very common. It causes pain, swelling and stiffness in the joints, which can often get worse when walking. Living with big toe joint arthritis can affect people’s day to day activities and impact on whether they can work and enjoy other activities and hobbies. We do not know the best way of helping people living with painful big toe arthritis. Some types of ...

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Basal thumb osteoarthritis (BTOA) is a common condition that affects 21% of the population by the age of 40 and 45% by the age of 80. BTOA causes significant problems in this large population with symptoms including pain, tenderness and stiffness. There are a variety of non-surgical and surgical treatments available for BTOA. If non-surgical treatment fails then surgical options can be offered (trapeziectomy and carpometacarpal joint replacement (CMCJR)). However there is a lack of high quality evidence comparing these ...

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This research aims to understand how ageing and blood thinners, widely prescribed to older adults, affect the body’s ability to stop bleeding after injuries like hip fractures. Blood thinners, used to prevent strokes and heart problems, reduce the blood’s ability to clot and are often thought to increase the risk of bleeding during surgery. As a result, doctors sometimes delay surgery for patients on blood thinners to minimise this risk. However, delays can lead to serious complications, including infections and ...

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This is a first-in-human phase 1 trial to assess the safety,tolerability,and immunogenicity of two doses of ChAdOx1 LassaJ in healthy volunteers aged 18-55 years. There will be an initial lead-in cohort (cohort 1) of 6 participants,followed by a participant-observer blinded cohort of 25 participants cohort (cohort 2). Participants in cohort 2 will be randomly assigned to subgroups,one of which will receive 2 doses of the ChAdOx1 LassaJ vaccine 12 weeks apart (20 participants) and the other group will receive ...

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COPD is the third leading cause of deaths worldwide. Lung volume reduction (LVR) therapy improves symptoms and life expectancy in severe COPD. The damaged lungs in COPD become overinflated which may cause compression of the more efficient parts of the lung. One-way expiratory endobronchial valves have been developed to be placed in the airways leading to the overinflated lung by bronchoscopy, only allowing air to exit the lung causing deflation and LVR. In some cases, air can enter the targeted ...

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StratMedPaeds2 aims to develop new tests that identify treatment for children who fail therapy and experience cancer relapse. It builds on the success achieved in StratMedPaeds1, which provided a national pathway to molecularly test tumour tissue and blood in children who relapse, and feed usable information about treatment and mechanisms of treatment failure to clinicians and researchers seeking to improve survival for these children. Having delivered several effective tests to the NHS, StratMedPaeds2 will move on to address four important ...

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Focal cortical dysplasia (FCD) is a malformation of brain development, the most common cause of drug-resistant epilepsy and often caused by mutations in mammalian target of rapamycin (mTOR) pathway genes. Patients with FCD develop drug-resistant seizures. Our study will look at FCD tissue removed during epilepsy surgery and aims to detect mutations in mTOR pathway genes in brain cells. Secondly, we will establish if evidence of mutations found in brain cells can also be detected as circulating free DNA (cfDNA) ...

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Inflammatory skin diseases account for an enormous physical and psychological burden. Although there have been tremendous improvements in the range of available treatments, there remains a major unmet medical need, not least of all because the majority of the advances are only approved for those with the most severe forms of disease. The other 80-90% of affected individuals are largely unable to benefit. Here, we aim to study the immune responses which are involved in driving skin ...

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This is a Phase 3, multi-center, randomized, double-blind, placebo controlled 3-arm study designed to assess the efficacy and safety of BHV7000 in participants with refractory focal epilepsy who are stable on at least one ASM. Participants must be considered uncontrolled on their current ASM regimen, defined as the occurrence of a minimum of an average of 6 seizures during an 8-week OP and no more than 21 consecutive days without a focal seizure in the OP. The study is planned to ...

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