This is a global open-label, randomized, multicenter, interventional study in pregnant participants with a prior FNAIT-affected pregnancy to assess the efficacy, safety, tolerability, PK, PD, and immunogenicity of nipocalimab or IVIG. ‘IVIG’ throughout the protocol will be referring to the IVIG with or without prednisone regimen adapted from Bussel et al (Bussel 2021). The studywill target participants whose current pregnancies are affected by HPA-1a and/or HPA-5b incompatibility. Maternal participants with alloantibodies against both HPA-1a and HPA-5b will be categorized under HPA-1a ...

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Kidney transplantation is the optimal treatment for chronic kidney failure, offering extended life and freedom from dialysis. However, in 2019/20, of the 8,300 UK patients on the transplant list, only 3,400 received a kidney, while 3,300 were suspended, and 400 died waiting. To address the organ shortage, more kidneys from higher-risk donors, such as those donated after circulatory death (DCD) or from older/sicker individuals, are being used. These kidneys are at greater risk of poor long-term function, often requiring recipients ...

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Background Epilepsy is a condition that affects the brain and causes seizures. Seizures are strong bursts of electrical activity in the brain that can lead to loss of consciousness, shaking and confusion. They increase the risk of falls and injuries and can affect people’s independence, ability to work, and care for others. Every year in the UK around 2,500 women with epilepsy get pregnant. Epilepsy is one of the leading causes of maternal death and women with epilepsy face higher risks ...

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Bone conduction devices (BCD's) are hearing aids which are given to people with a mixed or conductive hearing loss to improve their hearing. These devices deliver sounds to the patient by sending vibrations through the skull to stimulate the hearing organ. This study is looking to see if patients with a smaller degree of mixed or conductive hearing loss than would normally be considered for a BCD also so benefit from a BCD when we compare their speech understanding with ...

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Title: Cryopreservation of prepubertal testicular tissue for preservation of fertility in young boys with cancer Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys. With informed consent, we aim to cryopreserve (freeze) testis tissue biopsies taken from boys undergoing cancer therapy with a high risk of infertility. A portion of cryopreserved tissue will be securely stored which in the future may be used to ...

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(Diffuse) large B-cell lymphoma (D)LBCL is a cancer of the lymphatic system. Approximately 5,500 people are diagnosed with LBCL per year in the United Kingdom (UK), representing approximately 30-40% of people diagnosed with non-Hodgkin lymphoma (NHL). The usual treatment for patients newly diagnosed with LBCL is a combination of anti-cancer drugs called R-CHOP which are given for approximately 6 months. In practice, around half the patients diagnosed with LBCL are unsuitable for ‘full-dose’ and standard of care R-CHOP or Pola-R-CHP ...

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Each year in the UK, around 37,000 patients have radiotherapy for breast cancer. Radiotherapy uses radiation to kill cancer cells. Radiotherapy is given to the breast and, if needed, to the lymph node regions in daily doses. Until recently most patients needed at least 15 daily treatments of radiotherapy. In addition, around 10,000 women per year in the UK needed up to 8 extra radiation treatments to the part of the breast where the cancer was, resulting in a total ...

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The overall aims of the study are: •To determine if the combination of iberdomide and isatuximab with dexamethasone is safe and well tolerated •To determine if the treatment is efficacious in inducing disease response in high-risk smouldering myeloma,thus preventing the development of active multiple myeloma The primary endpoints are: •Treatment deliverability,measured by treatment discontinuation before completion of 26 cycles •Efficacy measured by best overall response rate =by the end of treatment The secondary endpoints are: •Progression Free Survival •Time to biochemical progression •Progression Free Survival 2 •Best ...

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Rheumatoid Arthritis (RA) is a condition that causes joint inflammation which leads to joint deformity and long-term disability. It affects 580,000 adults in England and costs £1.8 billion per year to the UK economy due to work-related disability. Biologic treatments are available for patients with severe disease who do not respond to first-line anti-rheumatic medications. However, only a proportion of patients with inflammatory arthritis respond to these expensive treatments, which results in unnecessary treatment and significant cost to the National Health ...

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The relationship between cabergoline treatment of prolactinoma,the most frequently occurring secretory pituitary tumour and psychiatric side effects remains unclear. Understanding the frequency with which these side effects occur,particularly impulse control disorders and the risk factors for their development is important for healthcare professionals to counsel and monitor patients. This is a prospective study using questionnaires at specific timepoints to investigate psychiatric side effects of cabergoline in patients receiving this for the management of prolactinomas. STUDY OBJECTIVES Primary objective To investigate the ...

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