OUH STUDIES

Studies currently being run within Oxford University Hospitals NHS Foundation Trust.

Showing 41 - 50 of 699 studies

Stroke

A streamlined multi-staged cognitive screening approach: validity of the Multistage Cognitive Screening app for Stroke (MCS-Stroke)

Following informed consent/consultee declaration,a member of the research will collect relevant clinical and demographic information from the participant and their clinical notes (e.g. age,gender,ethnicity,highest level of education,clinical diagnosis,month and year of stroke,previous strokes (yes/no),cognitive status). These will be recorded on the Trial Entry Form. Participants contact details and preferred mode of contact will also be recorded in the Trial Entry Form. The Trial Entry Form will be shared with the research team using the Microsoft OneDrive server link hosted by ...

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Infection Respiratory

Utilising the air-liquid interface model to understand the association between respiratory syncytial virus infection and lung remodelling in the development of childhood asthma

The overall aim of this study is to elucidate the molecular and cellular mechanisms underlying RSV-induced lung remodelling that contributes to the development of chronic lung disease such as asthma. This can be split into three objectives: 1. Comparison of RSV-induced responses in bronchial ALI cultures derived from asthmatic and non-asthmatic paediatric patients. 2. Determining secreted factors from RSV-infected bronchial ALI cultures that drive fibroblast-myofibroblast differentiation and fibrosis. 3. Transcriptomic analysis and comparison of bronchial cells from RSV-infected patients and bronchial ALI cultures from asthmatic ...

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Neurological Stroke

Antiplatelet Secondary Prevention International Randomised study after INtracerebral haemorrhaGe (ASPIRING): an investigator-initiated, multicentre, pragmatic, prospective, randomised, parallel group, open clinical trial of an investigational medicinal product

Stroke due to intracerebral haemorrhage (ICH) is a devastating cardiovascular disease that causes 48% of disability-adjusted life years due to stroke. ICH survivors are at high risk of further major adverse cardiovascular or cerebrovascular events (MACE, i.e. hospitalisation due to stroke [ischaemic or ICH], hospitalisation due to myocardial infarction, or cardiovascular death [by ischaemia, bleeding or other vascular causes]). In the REstart or STop Antithrombotics Randomised Trial (RESTART) of 537 people with cardiovascular diseases who survived ICH in the UK, ...

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Eye Metabolic and Endocrine

The effect of the distribution of panretinal photocoagulation (PRP) laser on driving visual fields in people with diabetes

Maintaining adequate vision for safe driving is a common concern for people with diabetic eye disease. One of the typical treatments for severe levels of diabetic eye disease is panretinal photocoagulation (PRP) laser treatment. Although PRP laser has been shown to halve the risk of severe vision loss and help to stabilise diabetic eye disease in the long term, it causes laser scars that can affect peripheral vision. In addition to visual acuity standards (reading a number plate from 20m), ...

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Oral and Gastrointestinal

ACESO trial: Upadacitinib Co-therapy with Corticosteroids in Early Acute Severe Ulcerative Colitis (A Phase III randomised placebo controlled double blinded trial) (ACESO)

The study will be a pragmatic,Phase IIIb,two-arm,double-blind randomised (1:1) placebo-controlled trial of ASUC patients admitted to UK National Health Service (NHS) hospitals. The study will recruit 300 patients admitted to hospital with suspected ASUC over ~30 months across up to 30 UK sites. Participant involvement in the study will depend on their response to IMP or placebo treatment. Screening,baseline assessment and randomisation will take place within 36 hours from the first dose of IV corticosteroids. The initial blinded IMP or placebo treatment ...

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Cardiovascular

The rare arrhythmia syndrome evaluation (RASE) 100K genomes project: Enhanced phenotyping for greater insights (RASE GEL)

Three main arrhythmia syndrome phenotypes currently included in the Genomics England (GEL) 100K Genomes Project are: long QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPVT). These disorders are responsible for much of unexplained sudden cardiac death (SCD), an important cause of death in Western countries. A substantial proportion of arrhythmia syndromes are presumed to be due to rare and common genetic variation, however their genetics are variably understood at present and no condition has been ascertained completely. We ...

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Cancer and neoplasms

A Cancer Research UK Phase II open label trial in participants with metastatic pancreatic ductal adenocarcinoma of ginisortamab given intravenously i) with first-line standard of care nab-paclitaxel and gemcitabine, or ii) in combination with MEK inhibitor maintenance therapy. (UCB6114)

We are testing a drug called ginisortamab that blocks a protein called gremlin-1. Gremlin-1 is mainly found outside cancer cells and stops the function of other proteins called bone morphogenetic proteins (BMPs). BMP proteins work by suppressing cancer cells as they occur but in cancer, this mechanism has often been switched off. Blocking gremlin-1 with ginisortamab will allow BMP protein function, and we hope this will change the way the cancer cells develop, making them more sensitive to chemotherapy. We are testing ginisortamab ...

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Cancer and neoplasms

Adjuvant Radiotherapy in Patients with High-risk Primary Cutaneous Squamous Cell Carcinoma AFTER surgery (SCC-AFTER): An Open Label, Multicentre, Two-arm Phase III Randomised trial.

Research question In patients who have a high-risk primary cutaneous squamous cell carcinoma (HR-cSCC) surgically excised with clear margins,is adjuvant radiotherapy plus close clinical follow-up superior in reducing the risk of loco-regional recurrence compared with close clinical follow-up alone,and if so,is it cost-effective? Background cSCC is the second most common skin cancer in the UK,with annual incidence exceeding 52,000,increasing by 6% p.a (1,2). Treatment,usually surgery,is curative in 95% (3,4). However,5% of patients develop loco-regional recurrence (LRR) which causes 75% of cSCCspecific mortality,substantial morbidity and reduced quality of life (QoL) ...

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Cancer and neoplasms

Exploring the Molecular and Microenvironmental factors in Risk of monoclonal Gammopathy Evolution (EMERGE)

Myeloma is a treatable, but incurable, malignancy of plasma cells in the bone marrow (BM). It represents the final stage in a continuum of plasma cell disorders (PCDs) and is consistently preceded by a premalignant phase termed monoclonal gammopathy of undetermined significance (MGUS). MGUS therefore provides the opportunity to study how a premalignant condition progresses into cancer. MGUS-to-myeloma progression requires multiple genomic events and establishment of a permissive bone marrow microenvironment (BME). Historically, obtaining patient material to study MGUS has ...

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Cancer and neoplasms

Randomized study to assess revumenib in combination with azacitidine + venetoclax in adult patients with newly diagnosed NPM1-mutated or KMT2A-rearranged AML ineligible for intensive chemotherapy (EVOLVE 2)

The proposed trial tests whether the addition of revumenib,compared to placebo,to azacitidine/venetoclax improves outcome in newly diagnosed adult patients with NPM1-mutated AML,who are not considered candidates for intensive chemotherapy by measuring overall survival. Newly diagnosed,previously untreated patients ≥18 years of age with NPM1-mutated or KMT2A-rearranged AML that are eligible for the study will be randomised in a 1:1 ratio to therapy with azacitidine/venetoclax with revumenib or placebo. Treatment will be on a continuous 28-day cycle schedule and continued until disease progression,development ...

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