Inflammatory and immune system

UK Juvenile Systemic Lupus Erythematosus registry and Repository "Clinical characteristics and immunopathology of juvenile-onset systemic lupus & erythematosus"

UK-wide study of children and young people with juvenile-onset SLE. The aims of establishing a collaborative national Cohort Study and Repository of patients with JSLE with comprehensive collection of clinical data as well as biological samples are to: 1. Facilitate hypothesis driven research into JSLE 2. Determine the demographics of JSLE 3. Perform descriptive analyses of disease presentation, activity, and damage in JSLE and response to medication 4. Determine prognostic markers in JSLE 5. Establish the mortality rate of patients with JSLE and describe the causes of death 6. Determine the long-term ...

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Oral and Gastrointestinal

Investigation of the genetic and molecular pathogenesis of primary biliary cirrhosis. Protocol Amendment 3, dated 05 March 2008. Substantial Amendment 10 dated 09Dec2010

The PBC Genetics Study is a national effort to establish a PBC DNA collection consisting of DNA samples from approximately 5000 patients with PBC. The DNA collection has already been used for a genome-wide association study (GWAS) of PBC. The next major analysis will be a genome wide association study of response to Ursodeoxycholic acid (UDCA).

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Colorectal cancer susceptibility study - development of a strategy for the delivery of genetic screening and counselling and or targetting cancer prevention modalities MREC03/0/48

To identify mutation carriers in collaboration with the NHS Regional Genetics Services and recruit them and their relatives. This will allow the identification of genetic and environmental modifiers on colorectal cancer.

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Cardiovascular Stroke

The Oxford Vascular Study: a population-based study of the incidence and outcome of stroke, transient ischaemic attack, acute coronary syndromes and peripheral vascular events (OXVASC)

The OXVASC study is a community-based study of all acute vascular events occuring in a population of approximately 91,000 people registered with 9 GP practices (approximately 70 GPs) in Oxfordshire. The study acsertains and recruits patients admitted to local hospitals following transient ischaemic attacks, strokes, acute coronary syndromes and acute peripheral vascular disease events. Patients recruited undergo a detailed interview and collection of blood samples and regular follow up. The study also provides an emergency referral clinic for ...

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A prospective, real-world registry of acute myeloid leukaemia patients in the United Kingdom

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In vivo investigation of immune dynamics following cutaneous challenge (VIVID)

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Cardiovascular

A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Orticumab in Participants with Prior Myocardial Infarction who have Elevated Coronary Inflammation Based on Fat Attenuation Index (FAI) Score Assessed by Coronary Computed Tomography Angiography (CCTA) (FORTIFY)

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Placental Biology in Health and Disease

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Clinical Management and Short-Term Outcomes of Neonates Born at 22 Weeks in UK Neonatal Intensive Care Units

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Observational multi-centre study comparing fasciculation frequency detected using motor unit MRI (MUMRI) across scanner make and magnet strength.

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