CRYSTAL is an observational study whereby participants will attend one 4 ½ -hour visit at the Division of Cardiovascular Medicine,University of Oxford at the John Radcliffe Hospital in Oxford,with the option to split the study visit over two days for convenience. Participants will be recruited from the ALSPAC cohort (G0 mothers cohort),75 will have had a hypertensive pregnancy and 75 will have had a normotensive pregnancy. At time of follow-up,they will be 30-35 years post pregnancy. Of the G0 cohort,2237 ...

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Our aim is to see if palliative long-term abdominal drains (LTADs) result in better quality of life in patients with fluid in the belly due to liver scarring (cirrhosis), compared with current standard of care. The liver can be damaged by excessive alcohol and viral infections. If liver damage continues this scarring leads to permanent damage. It causes a painful buildup of fluid in the abdomen (ascites). Drugs can treat this, but may stop working, leading to ...

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GLO-Surgery is an open label,randomised,international,phase II clinical trial comparing fluorescence guided surgery (FGS) using Indocyanine Green (ICG) and near infra-red fluorescence (NIRF) to surgery using standard white light conditions.

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Following informed consent/consultee declaration,a member of the research will collect relevant clinical and demographic information from the participant and their clinical notes (e.g. age,gender,ethnicity,highest level of education,clinical diagnosis,month and year of stroke,previous strokes (yes/no),cognitive status). These will be recorded on the Trial Entry Form. Participants contact details and preferred mode of contact will also be recorded in the Trial Entry Form. The Trial Entry Form will be shared with the research team using the Microsoft OneDrive server link hosted by ...

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The overall aim of this study is to elucidate the molecular and cellular mechanisms underlying RSV-induced lung remodelling that contributes to the development of chronic lung disease such as asthma. This can be split into three objectives: 1. Comparison of RSV-induced responses in bronchial ALI cultures derived from asthmatic and non-asthmatic paediatric patients. 2. Determining secreted factors from RSV-infected bronchial ALI cultures that drive fibroblast-myofibroblast differentiation and fibrosis. 3. Transcriptomic analysis and comparison of bronchial cells from RSV-infected patients and bronchial ALI cultures from asthmatic ...

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Stroke due to intracerebral haemorrhage (ICH) is a devastating cardiovascular disease that causes 48% of disability-adjusted life years due to stroke. ICH survivors are at high risk of further major adverse cardiovascular or cerebrovascular events (MACE, i.e. hospitalisation due to stroke [ischaemic or ICH], hospitalisation due to myocardial infarction, or cardiovascular death [by ischaemia, bleeding or other vascular causes]). In the REstart or STop Antithrombotics Randomised Trial (RESTART) of 537 people with cardiovascular diseases who survived ICH in the UK, ...

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Maintaining adequate vision for safe driving is a common concern for people with diabetic eye disease. One of the typical treatments for severe levels of diabetic eye disease is panretinal photocoagulation (PRP) laser treatment. Although PRP laser has been shown to halve the risk of severe vision loss and help to stabilise diabetic eye disease in the long term, it causes laser scars that can affect peripheral vision. In addition to visual acuity standards (reading a number plate from 20m), ...

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The study will be a pragmatic,Phase IIIb,two-arm,double-blind randomised (1:1) placebo-controlled trial of ASUC patients admitted to UK National Health Service (NHS) hospitals. The study will recruit 300 patients admitted to hospital with suspected ASUC over ~30 months across up to 30 UK sites. Participant involvement in the study will depend on their response to IMP or placebo treatment. Screening,baseline assessment and randomisation will take place within 36 hours from the first dose of IV corticosteroids. The initial blinded IMP or placebo treatment ...

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Three main arrhythmia syndrome phenotypes currently included in the Genomics England (GEL) 100K Genomes Project are: long QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPVT). These disorders are responsible for much of unexplained sudden cardiac death (SCD), an important cause of death in Western countries. A substantial proportion of arrhythmia syndromes are presumed to be due to rare and common genetic variation, however their genetics are variably understood at present and no condition has been ascertained completely. We ...

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We are testing a drug called ginisortamab that blocks a protein called gremlin-1. Gremlin-1 is mainly found outside cancer cells and stops the function of other proteins called bone morphogenetic proteins (BMPs). BMP proteins work by suppressing cancer cells as they occur but in cancer, this mechanism has often been switched off. Blocking gremlin-1 with ginisortamab will allow BMP protein function, and we hope this will change the way the cancer cells develop, making them more sensitive to chemotherapy. We are testing ginisortamab ...

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