Oral and Gastrointestinal

Investigation of the genetic and molecular pathogenesis of primary biliary cirrhosis. Protocol Amendment 3, dated 05 March 2008. Substantial Amendment 10 dated 09Dec2010

The PBC Genetics Study is a national effort to establish a PBC DNA collection consisting of DNA samples from approximately 5000 patients with PBC. The DNA collection has already been used for a genome-wide association study (GWAS) of PBC. The next major analysis will be a genome wide association study of response to Ursodeoxycholic acid (UDCA).

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Colorectal cancer susceptibility study - development of a strategy for the delivery of genetic screening and counselling and or targetting cancer prevention modalities MREC03/0/48

To identify mutation carriers in collaboration with the NHS Regional Genetics Services and recruit them and their relatives. This will allow the identification of genetic and environmental modifiers on colorectal cancer.

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Cardiovascular Stroke

The Oxford Vascular Study: a population-based study of the incidence and outcome of stroke, transient ischaemic attack, acute coronary syndromes and peripheral vascular events (OXVASC)

The OXVASC study is a community-based study of all acute vascular events occuring in a population of approximately 91,000 people registered with 9 GP practices (approximately 70 GPs) in Oxfordshire. The study acsertains and recruits patients admitted to local hospitals following transient ischaemic attacks, strokes, acute coronary syndromes and acute peripheral vascular disease events. Patients recruited undergo a detailed interview and collection of blood samples and regular follow up. The study also provides an emergency referral clinic for ...

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Cancer and neoplasms

CA266-0003: A Randomized Phase 2/3 Study of BMS-986545-01 (BNT327) in combination with Chemotherapy Versus Bevacizumab and Chemotherapy in Previously Untreated Participants with Unresectable, Recurrent, or Metastatic CRC. ROSETTA CRC-203 (ROSETTA CRC-203)

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CAPTIVATE - Diet-driven gut microbiome and outcome in patients with early-stage triple-negative breast cancer undergoing neoadjuvant chemotherapy and immunotherapy

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Musculoskeletal

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Global Study with an Open-Label Extension to Evaluate the Efficacy and Safety of Intravenous AOC 1044 (delpacibart zotadirsen) for the Treatment of DMD with Gene Mutations Amenable to Exon 44 Skipping (SAFARI44)

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Neurological

CHTT227A12301: A randomized, placebo-controlled, double-blind Phase 3 study to evaluate the efficacy, safety and tolerability of votoplam in participants with Huntington’s Disease (INVEST HD)

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A qualitative study examining patients' experiences with a neurological condition that requires occupational therapy cognitive assessment, exploring different areas of focus across impairment-based and occupation-based screens and assessments

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A Phase 1/2 Open-label, Dose-escalation, and Dose-expansion Study of mRNA-4194 in Participants with Lynch Syndrome (INTERCEPT-Lynch)

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A pilot mechanistic study to investigate the impact of Bimekizumab on liver inflammation in psoriatic disease

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